(Q36410400)

14 August 2017

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title

Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer (English)

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14 August 2017

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3

Jos H Beijnen

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14 August 2017

4

Jan H M Schellens

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14 August 2017

Tessa M Bosch

1

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14 August 2017

Irma Meijerman

series ordinal

2

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14 August 2017

publication date

1 January 2006

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Clinical Pharmacokinetics

14 August 2017

published in

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14 August 2017

volume

45

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14 August 2017

issue

3

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14 August 2017

page(s)

253-285

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Germline mutation of dihydropyrimidine dehydrogenese gene among a Japanese population in relation to toxicity to 5-Fluorouracil

14 August 2017

cites work

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12 December 2020

UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer

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12 December 2020

Life-threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil.

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12 December 2020

Human polymorphism in drug metabolism: mutation in the dihydropyrimidine dehydrogenase gene results in exon skipping and thymine uracilurea.

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12 December 2020

MDR1 gene polymorphisms affect therapy outcome in acute myeloid leukemia patients

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12 December 2020

Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism?

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12 December 2020

Arylamine N-acetyltransferase 1 (NAT1) genotypes in a Lebanese population

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12 December 2020

Influence of the variable number of tandem repeats located in the promoter region of the thiopurine methyltransferase gene on enzymatic activity

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12 December 2020

Charged amino acids in the transmembrane domains are involved in the determination of the substrate specificity of rat Mrp2.

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12 December 2020

Multidrug resistance related molecules in human and murine lung

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12 December 2020

Genetic variability in CYP3A5 and its possible consequences.

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12 December 2020

Polymorphisms within glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a case-control study

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12 December 2020

CYP3A genotypes and treatment response in paediatric acute lymphoblastic leukaemia

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12 December 2020

Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups

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12 December 2020

RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response.

1 reference

12 December 2020

Genetic polymorphism and outcomes with azathioprine and 6-mercaptopurine

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12 December 2020

Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome

1 reference

12 December 2020

Identification of two novel sequence variants affecting thiopurine methyltransferase enzyme activity

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12 December 2020

Analysis of thiopurine methyltransferase variant alleles in childhood acute lymphoblastic leukaemia

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12 December 2020

Pharmacokinetically guided administration of chemotherapeutic agents

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12 December 2020

Breast cancer resistance protein impacts clinical outcome in platinum-based chemotherapy for advanced non-small cell lung cancer

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12 December 2020

Association between sulfotransferase 1A1 genotype and survival of breast cancer patients receiving tamoxifen therapy

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12 December 2020

Induction of hepatic mrp2 (cmrp/cmoat) gene expression in nonhuman primates treated with rifampicin or tamoxifen

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12 December 2020

Association of CYP3A4 genotype with treatment-related leukemia

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12 December 2020

Influence of GSTM1, GSTT1, GSTP1, and EPHX gene polymorphisms on DNA adduct level and HPRT mutant frequency in coke-oven workers

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12 December 2020

Genetic contribution to variable human CYP3A-mediated metabolism

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12 December 2020

Clinical relevance of genetic polymorphisms in the human CYP2C subfamily

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12 December 2020

Association between a glutathione S-transferase A1 promoter polymorphism and survival after breast cancer treatment

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12 December 2020

Negative prognostic value of glutathione S-transferase (GSTM1 and GSTT1) deletions in adult acute myeloid leukemia

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12 December 2020

Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil

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12 December 2020

Nomenclature for human CYP2D6 alleles

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12 December 2020

Rapid detection of the C3435T polymorphism of multidrug resistance gene 1 using fluorogenic hybridization probes

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12 December 2020

Differential down-regulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer

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12 December 2020

Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.

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12 December 2020

Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome

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12 December 2020

Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies

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12 December 2020

Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus

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12 December 2020

Expression of breast cancer resistance protein in blast cells from patients with acute leukemia.

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12 December 2020

UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan

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12 December 2020

Absence of R1066X mutation in six Japanese patients with Dubin-Johnson syndrome

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12 December 2020

Breast cancer resistance protein expression and resistance to daunorubicin in blast cells from patients with acute myeloid leukaemia

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12 December 2020

Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer

1 reference

12 December 2020

Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lymphoblastic leukemia.

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12 December 2020

Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid.

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12 December 2020

Rapid, long-range molecular haplotyping of thiopurine S-methyltransferase (TPMT) *3A, *3B, and *3C.

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12 December 2020

Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene.

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12 December 2020

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12 December 2020

Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians

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12 December 2020

Association between survival after treatment for breast cancer and glutathione S-transferase P1 Ile105Val polymorphism

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12 December 2020

Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus

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12 December 2020

A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase

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12 December 2020

Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: correlation with phenotypic activity

1 reference

12 December 2020

Identification of novel mutations in the dihydropyrimidine dehydrogenase gene in a Japanese patient with 5-fluorouracil toxicity

1 reference

12 December 2020

Mutation analysis of the human CYP3A4 gene 5' regulatory region: population screening using non-radioactive SSCP

1 reference

12 December 2020

Severe CPT-11 toxicity in patients with Gilbert's syndrome: two case reports

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12 December 2020

Paclitaxel (taxol) inhibits the arylamine N-acetyltransferase activity and gene expression (mRNA NAT1) and 2-aminofluorene-DNA adduct formation in human bladder carcinoma cells (T24 and TSGH 8301).

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12 December 2020

Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.

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12 December 2020

Cisplatin induces renal expression of P-glycoprotein and canalicular multispecific organic anion transporter

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12 December 2020

Characterization of an allelic variant in the nifedipine-specific element of CYP3A4: ethnic distribution and implications for prostate cancer risk. Mutations in brief no. 191. Online

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12 December 2020

Suggestions for the nomenclature of human alleles: relevance to ecogenetics, pharmacogenetics and molecular epidemiology

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12 December 2020

Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines

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12 December 2020

Cytochrome P450 2C8: substrates, inhibitors, pharmacogenetics, and clinical relevance

1 reference

12 December 2020

Multidrug resistance and pharmacological protection mediated by the breast cancer resistance protein (BCRP/ABCG2).

1 reference

12 December 2020

Glutathione transferase P1 polymorphism in neuroblastoma studied by endonuclease restriction mapping

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12 December 2020

Prediction of response to docetaxel by CYP3A4 mRNA expression in breast cancer tissues

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12 December 2020

Glutathione S-transferase M1, T1, and P1 polymorphisms and survival among lung cancer patients.

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12 December 2020

Association of human liver bilirubin UDP-glucuronyltransferase activity with a polymorphism in the promoter region of the UGT1A1 gene

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12 December 2020

Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia

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12 December 2020

The role of glucuronidation in 7-ethyl-10-hydroxycamptothecin resistance in vitro

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12 December 2020

Multidrug resistance proteins MRP3, MRP1, and MRP2 in lung cancer: correlation of protein levels with drug response and messenger RNA levels

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12 December 2020

Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population.

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12 December 2020

Screening for azathioprine toxicity: a pharmacoeconomic analysis based on a target case

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12 December 2020

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

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12 December 2020

Lethal 5-fluorouracil toxicity associated with a novel mutation in the dihydropyrimidine dehydrogenase gene

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12 December 2020

Genetic determinants of the thiopurine methyltransferase intermediate activity phenotype in British Asians and Caucasians

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12 December 2020

CYP3A4 variant alleles in white individuals with low CYP3A4 enzyme activity

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12 December 2020

Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects

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12 December 2020

Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations

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12 December 2020

C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance.

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12 December 2020

Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms

1 reference

12 December 2020

Polymorphisms of UDP-glucuronosyltransferase and pharmacokinetics of irinotecan.

1 reference

12 December 2020

Pharmacogenetic and clinical aspects of dihydropyrimidine dehydrogenase deficiency

1 reference

12 December 2020

Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4.

1 reference

12 December 2020

Paradoxical relationship between acetylator phenotype and amonafide toxicity

1 reference

12 December 2020

Validation of methods for CYP2C9 genotyping: frequencies of mutant alleles in a Swedish population.

1 reference

12 December 2020

Genotype and allele frequencies of TPMT, NAT2, GST, SULT1A1 and MDR-1 in the Egyptian population

1 reference

12 December 2020

Paclitaxel affects the amounts of the N-acetylation of 2-aminofluorene and DNA-2-aminofluorene adduct formation in Sprague-Dawley rats.

1 reference

12 December 2020

Genotype-phenotype correlation for thiopurine S-methyltransferase in healthy Italian subjects

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12 December 2020

Possible prediction of the efficiency of chemotherapy in patients with lymphoproliferative diseases based on MDR1 gene G2677T and C3435T polymorphisms

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12 December 2020

Correspondence re: Raida, M. et al., prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5'-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with co

1 reference

12 December 2020

Phase I study of amonafide dosing based on acetylator phenotype.

1 reference

12 December 2020

Glutathione S-transferase genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin

1 reference

12 December 2020

Relationship between 5-fluorouracil disposition, toxicity and dihydropyrimidine dehydrogenase activity in cancer patients

1 reference

12 December 2020

Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation.

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12 December 2020

Known variant DPYD alleles do not explain DPD deficiency in cancer patients

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12 December 2020

Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia

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12 December 2020

Expression of multidrug resistance-related transporters in human breast carcinoma

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12 December 2020

Individualised cancer chemotherapy: strategies and performance of prospective studies on therapeutic drug monitoring with dose adaptation: a review

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12 December 2020

Multiplicity of biliary excretion mechanisms for the camptothecin derivative irinotecan (CPT-11), its metabolite SN-38, and its glucuronide: role of canalicular multispecific organic anion transporter and P-glycoprotein

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12 December 2020

Association between glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer

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12 December 2020

CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver

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12 December 2020

Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome

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12 December 2020

MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity

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12 December 2020

Familial pyrimidinemia and pyrimidinuria associated with severe fluorouracil toxicity

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12 December 2020

SNPs in cancer research and treatment

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12 December 2020

A mouse-based strategy for cyclophosphamide pharmacogenomic discovery.

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12 December 2020

Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine

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12 December 2020

Detection of single nucleotide polymorphisms in the ABCG2 gene in a Dutch population

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12 December 2020

UGT1A1 gene variations and irinotecan treatment in patients with metastatic colorectal cancer

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12 December 2020

Genetic polymorphisms in CYP3A5, CYP3A4 and NQO1 in children who developed therapy-related myeloid malignancies

1 reference

12 December 2020

Influence of functional polymorphisms of the MDR1 gene on vincristine pharmacokinetics in childhood acute lymphoblastic leukemia.

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12 December 2020

Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.

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12 December 2020

Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression

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12 December 2020

Profound dihydropyrimidine dehydrogenase deficiency resulting from a novel compound heterozygote genotype.

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12 December 2020

Possible implication of thiopurine S-methyltransferase in occurrence of infectious episodes during maintenance therapy for childhood lymphoblastic leukemia with mercaptopurine.

1 reference

12 December 2020

Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity

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12 December 2020

Pharmacogenomics of azathioprine and 6-mercaptopurine in gastroenterologic therapy

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12 December 2020

Homozygous mutation Arg768Trp in the ABC-transporter encoding gene MRP2/cMOAT/ABCC2 causes Dubin-Johnson syndrome in a Caucasian patient

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12 December 2020

Characterization of a variable number tandem repeat region in the thiopurine S-methyltransferase gene promoter

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12 December 2020

Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype

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12 December 2020

Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency

1 reference

12 December 2020

RNA expression of MDR1/P-glycoprotein, DNA-topoisomerase I, and MRP2 in ovarian carcinoma patients: correlation with chemotherapeutic response

1 reference

12 December 2020

Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos.

1 reference

12 December 2020

Irinotecan pathway genotype analysis to predict pharmacokinetics

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12 December 2020

Higher frequency of glutathione S-transferase deletions in black children with acute lymphoblastic leukemia.

1 reference

12 December 2020

Population study of dihydropyrimidine dehydrogenase in cancer patients

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12 December 2020

Genetic variation in the ATP-binding Cassette Transporter gene ABCG2 (BCRP) in a Swedish population

1 reference

12 December 2020

Identification and functional analysis of two rare allelic variants of the thiopurine S-methyltransferase gene, TPMT*16 and TPMT*19.

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12 December 2020

UDP-glucuronosyltransferase (UGT1A1*28 and UGT1A6*2) polymorphisms in Caucasians and Asians: relationships to serum bilirubin concentrations

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12 December 2020

Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2.

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12 December 2020

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

1 reference

12 December 2020

Allelic variants of the thiopurine S-methyltransferase deficiency in patients with ulcerative colitis and in healthy controls

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12 December 2020

Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5'-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)- related toxicity compared with controls.

1 reference

12 December 2020

CYP3A4-V polymorphism detection by PCR-restriction fragment length polymorphism analysis and its allelic frequency among 199 Dutch Caucasians

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12 December 2020

Pharmacogenetics as a molecular basis for individualized drug therapy: the thiopurine S-methyltransferase paradigm

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12 December 2020

Multidrug resistance-associated protein subfamily transporters and drug resistance

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12 December 2020

Increased risk of grade IV neutropenia after administration of 5-fluorouracil due to a dihydropyrimidine dehydrogenase deficiency: high prevalence of the IVS14+1g>a mutation

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12 December 2020

Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine.

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12 December 2020

Expression of the breast cancer resistance protein in breast cancer.

1 reference

12 December 2020

Dexamethasone as a probe for docetaxel clearance.

1 reference

12 December 2020

Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity.

1 reference

12 December 2020

CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment

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12 December 2020

Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML)

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12 December 2020

Expression and activity of breast cancer resistance protein (BCRP) in de novo and relapsed acute myeloid leukemia.

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12 December 2020

Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism

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12 December 2020

Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population.

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12 December 2020

Thiopurine methyltransferase polymorphic tandem repeat: genotype-phenotype correlation analysis

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12 December 2020

Identification of functionally variant MDR1 alleles among European Americans and African Americans

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12 December 2020

BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia

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12 December 2020

Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity

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12 December 2020

Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome

1 reference

12 December 2020

Effects of polymorphisms of MDR1, MRP1, and MRP2 genes on their mRNA expression levels in duodenal enterocytes of healthy Japanese subjects

1 reference

12 December 2020

Sulfation pharmacogenetics: SULT1A1 and SULT1A2 allele frequencies in Caucasian, Chinese and African-American subjects

1 reference

12 December 2020

Non-synonymous single nucleotide alterations found in the CYP2C8 gene result in reduced in vitro paclitaxel metabolism

1 reference

12 December 2020

Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: a pharmacogenetic analysis.

1 reference

12 December 2020

Pharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy

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12 December 2020

Population distribution and effects on drug metabolism of a genetic variant in the 5' promoter region of CYP3A4

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12 December 2020

Pharmacogenetics of tipifarnib (R115777) transport and metabolism in cancer patients

1 reference

12 December 2020

Genotyping of eight thiopurine methyltransferase mutations: three-color multiplexing, "two-color/shared" anchor, and fluorescence-quenching hybridization probe assays based on thermodynamic nearest-neighbor probe design.

1 reference

12 December 2020

Polymorphisms within glutathione S-transferase genes in pediatric non-Hodgkin's lymphoma.

1 reference

12 December 2020

Genetic determinants of the pre- and post-azathioprine therapy thiopurine methyltransferase activity phenotype

1 reference

12 December 2020

Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infus

1 reference

12 December 2020

Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded material

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12 December 2020

Identification and functional characterization of eight CYP3A4 protein variants

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12 December 2020

Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants

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12 December 2020

Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data.

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12 December 2020

Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population.

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12 December 2020

Increased expression of multidrug resistance-associated proteins in bladder cancer during clinical course and drug resistance to doxorubicin

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12 December 2020

Pharmacogenetic associations of CYP2C19 genotype with in vivo metabolisms and pharmacological effects of thalidomide.

1 reference

12 December 2020

Genotyping human polymorphic arylamine N-acetyltransferase: identification of new slow allotypic variants.

1 reference

12 December 2020

UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity

1 reference

12 December 2020

Induction of cMrp/cMoat gene expression by cisplatin, 2-acetylaminofluorene, or cycloheximide in rat hepatocytes.

1 reference

12 December 2020

Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region

1 reference

12 December 2020

Phenotype and genotype for thiopurine methyltransferase activity in the French Caucasian population: impact of age.

1 reference

12 December 2020

Allelic, genotypic and phenotypic distributions of S-mephenytoin 4'-hydroxylase (CYP2C19) in healthy Caucasian populations of European descent throughout the world

1 reference

12 December 2020

Population pharmacodynamic study of amonafide: a Cancer and Leukemia Group B study

1 reference

12 December 2020

Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene

1 reference

12 December 2020

A comparison of molecular and enzyme-based assays for the detection of thiopurine methyltransferase mutations

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12 December 2020

Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas.

1 reference

12 December 2020

Up-regulation of transporters of the MRP family by drugs and toxins

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12 December 2020

P-glycoprotein and bioavailability-implication of polymorphism

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12 December 2020

Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency.

1 reference

12 December 2020

Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8

1 reference

12 December 2020

Expression and functional analyses of breast cancer resistance protein in lung cancer.

1 reference

12 December 2020

Effect of glutathione S-transferases on the survival of patients with acute myeloid leukaemia

1 reference

12 December 2020

The role of MDR1 genetic polymorphisms in interindividual variability in P-glycoprotein expression and function

1 reference

12 December 2020

Impact of inter-individual differences in drug metabolism and pharmacokinetics on safety evaluation

1 reference

12 December 2020

ABCG2 pharmacogenetics: ethnic differences in allele frequency and assessment of influence on irinotecan disposition

1 reference

12 December 2020

Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutations in the DPD gene

1 reference

12 December 2020

High prevalence of the IVS14 + 1G>A mutation in the dihydropyrimidine dehydrogenase gene of patients with severe 5-fluorouracil-associated toxicity

1 reference

12 December 2020

CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes

1 reference

12 December 2020

Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): its impact on drug disposition

1 reference

12 December 2020

Cytochrome P-450 mRNA Expression in Human Liver and Its Relationship with Enzyme Activity

1 reference

12 December 2020

Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia

1 reference

12 December 2020

Interindividual differences in hepatic expression of CYP3A4: relationship to genetic polymorphism in the 5'-upstream regulatory region

1 reference

12 December 2020

Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by C190T and G560A mutations

1 reference

12 December 2020

Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan

1 reference

12 December 2020

Multidrug resistance in cancer: role of ATP-dependent transporters

1 reference

12 December 2020

Polymorphisms within glutathione S-transferase genes and initial response to glucocorticoids in childhood acute lymphoblastic leukaemia.

1 reference

12 December 2020

New developments in the immunosuppressive drug monitoring of cyclosporine, tacrolimus, and azathioprine

1 reference

12 December 2020

Anticancer drugs as inhibitors of two polymorphic cytochrome P450 enzymes, debrisoquin and mephenytoin hydroxylase, in human liver microsomes

1 reference

12 December 2020

Polymorphism C3435T of the MDR-1 gene predicts response to preoperative chemotherapy in locally advanced breast cancer

1 reference

12 December 2020

Pharmacoeconomic analysis of thiopurine methyltransferase polymorphism screening by polymerase chain reaction for treatment with azathioprine in Korea.

1 reference

12 December 2020

Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes

1 reference

12 December 2020

Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance

1 reference

12 December 2020

Single-nucleotide polymorphism (SNP) analysis in the ABC half-transporter ABCG2 (MXR/BCRP/ABCP1).

1 reference

12 December 2020

Correlation between dihydropyrimidine dehydrogenase activity in peripheral mononuclear cells and systemic clearance of fluorouracil in cancer patients

1 reference

12 December 2020

A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport.

1 reference

12 December 2020

Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome

1 reference

12 December 2020

CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity

1 reference

12 December 2020

Multidrug resistance gene G1199A polymorphism alters efflux transport activity of P-glycoprotein

1 reference

12 December 2020

MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects

1 reference

12 December 2020

Single nucleotide polymorphisms result in impaired membrane localization and reduced atpase activity in multidrug transporter ABCG2.

1 reference

12 December 2020

Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects.

1 reference

12 December 2020

The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics

1 reference

12 December 2020

CYP3A activity in African American and European American men: population differences and functional effect of the CYP3A4*1B5'-promoter region polymorphism

1 reference

12 December 2020

Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans

1 reference

12 December 2020

Pharmacogenetics of the arylamine N-acetyltransferases.

1 reference

12 December 2020

(TA)8 allele in the UGT1A1 gene promoter of a Caucasian with Gilbert's syndrome

1 reference

12 December 2020

Heterozygosity for a point mutation in an invariant splice donor site of dihydropyrimidine dehydrogenase and severe 5-fluorouracil related toxicity

1 reference

12 December 2020

Dihydropyrimidinase deficiency and severe 5-fluorouracil toxicity.

1 reference

12 December 2020

10.2165/00003088-200645030-00003

Identifiers

DOI

1 reference

Dimensions Publication ID

14 August 2017

1052779934

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