(Q36410666)

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Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosis

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scholarly article

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Europe PubMed Central

PMC publication ID

14 August 2017

Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosis (English)

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Europe PubMed Central

PMC publication ID

14 August 2017

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Ralph A. DeFronzo

10

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Ralph A DeFronzo

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Europe PubMed Central

14 August 2017

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author name string

Jingjing Zhang

1

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Europe PubMed Central

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14 August 2017

Ning Zhang

2

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14 August 2017

Meilian Liu

3

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Europe PubMed Central

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14 August 2017

Xiuling Li

4

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14 August 2017

Lijun Zhou

5

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14 August 2017

Wei Huang

6

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14 August 2017

Zhipeng Xu

7

1 reference

Europe PubMed Central

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14 August 2017

Jing Liu

8

1 reference

Europe PubMed Central

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14 August 2017

Nicolas Musi

9

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Europe PubMed Central

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14 August 2017

John M Cunningham

11

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Europe PubMed Central

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14 August 2017

Zhiguang Zhou

12

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14 August 2017

Xin-Yun Lu

13

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14 August 2017

Feng Liu

14

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14 August 2017

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publication date

24 August 2012

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Europe PubMed Central

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14 August 2017

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Europe PubMed Central

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14 August 2017

61

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Europe PubMed Central

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14 August 2017

12

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Europe PubMed Central

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14 August 2017

3189-3198

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Europe PubMed Central

PMC publication ID

14 August 2017

copyright license

Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

30 August 2021

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April 2022 Public Data File from Crossref

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Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501856

30 September 2017

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

1 reference

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30 September 2017

Distinct physiological and behavioural functions for parental alleles of imprinted Grb10

1 reference

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30 September 2017

Critical roles for the TSC-mTOR pathway in β-cell function

1 reference

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30 September 2017

Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis

1 reference

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30 September 2017

Insulin signaling in alpha cells modulates glucagon secretion in vivo

1 reference

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30 September 2017

mTORC1 activation regulates beta-cell mass and proliferation by modulation of cyclin D2 synthesis and stability

1 reference

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30 September 2017

A mono-allelic bivalent chromatin domain controls tissue-specific imprinting at Grb10

1 reference

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30 September 2017

Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo

1 reference

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30 September 2017

Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life

1 reference

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30 September 2017

Glucose regulates Foxo1 through insulin receptor signaling in the pancreatic islet beta-cell

1 reference

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30 September 2017

Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation

1 reference

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30 September 2017

Grb10 and Grb14: enigmatic regulators of insulin action--and more?

1 reference

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30 September 2017

Five stages of evolving beta-cell dysfunction during progression to diabetes

1 reference

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30 September 2017

Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells

1 reference

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30 September 2017

Grb10: more than a simple adaptor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501856

30 September 2017

Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501856

30 September 2017

Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501856

30 September 2017

Imprinting regulation of the murine Meg1/Grb10 and human GRB10 genes; roles of brain-specific promoters and mouse-specific CTCF-binding sites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501856

30 September 2017

Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501856

30 September 2017

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501856

30 September 2017

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501856

30 September 2017

beta-Cell death during progression to diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501856

30 September 2017

Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501856

30 September 2017

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

1 reference

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30 September 2017

Life and death of the pancreatic beta cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501856

30 September 2017

Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells

1 reference

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Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains

1 reference

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Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling

1 reference

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Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus

1 reference

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An immunocytochemical and morphometric study of the rat pancreatic islets

1 reference

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Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function

1 reference

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30 September 2017

Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus

1 reference

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Glucocorticoids modulate the in vitro development of the embryonic rat pancreas

1 reference

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CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse.

1 reference

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Type 2 diabetes mellitus in a non-obese mouse model induced by Meg1/Grb10 overexpression

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mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes

1 reference

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Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation

1 reference

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21 September 2018

Meg1/Grb10 overexpression causes postnatal growth retardation and insulin resistance via negative modulation of the IGF1R and IR cascades.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501856

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Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice

1 reference

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beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass

1 reference

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The BPS domain of Grb10 inhibits the catalytic activity of the insulin and IGF1 receptors

1 reference

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beta-cell turnover: its assessment and implications

1 reference

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Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

1 reference

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Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

1 reference

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21 September 2018

Foetal rat pancreas in organ culture: effects of media supplementation with various steroid hormones on the acinar and islet components

1 reference

https://pubmed.ncbi.nlm.nih.gov/22923474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-directed mutagenesis and yeast two-hybrid studies of the insulin and insulin-like growth factor-1 receptors: the Src homology-2 domain-containing protein hGrb10 binds to the autophosphorylated tyrosine residues in the kinase domain of the insul

1 reference

https://pubmed.ncbi.nlm.nih.gov/22923474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon is required for early insulin-positive differentiation in the developing mouse pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/22923474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass

1 reference

https://pubmed.ncbi.nlm.nih.gov/22923474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2337/DB12-0249

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

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