(Q36770323)

16 August 2017

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title

Pharmacological neuroprotection for glaucoma (English)

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16 August 2017

Glyn Chidlow

1

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16 August 2017

John P M Wood

series ordinal

2

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16 August 2017

Robert J Casson

series ordinal

3

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16 August 2017

publication date

1 January 2007

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16 August 2017

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16 August 2017

volume

67

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16 August 2017

issue

5

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16 August 2017

page(s)

725-759

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Neurotoxicity at the N-methyl-D-aspartate receptor in energy-compromised neurons. An hypothesis for cell death in aging and disease.

16 August 2017

cites work

1 reference

12 December 2020

Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage

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12 December 2020

Neuroprotective effect of latanoprost on rat retinal ganglion cells

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12 December 2020

Alpha2-adrenoreceptor agonists are neuroprotective in a rat model of optic nerve degeneration

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12 December 2020

Longterm visual field follow-up of glaucoma patients treated with beta-blockers

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12 December 2020

Vaccination for neuroprotection in the mouse optic nerve: implications for optic neuropathies.

1 reference

12 December 2020

Effect of dorzolamide and timolol on ocular blood flow in patients with primary open angle glaucoma and ocular hypertension

1 reference

12 December 2020

Akt is activated via insulin/IGF-1 receptor in rat retina with episcleral vein cauterization

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12 December 2020

Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer's disease: anti-apoptosis by alpha-2-adrenergic receptor activation

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12 December 2020

Vitreous amino acid concentrations in patients with glaucoma undergoing vitrectomy.

1 reference

12 December 2020

Evaluation of inducible nitric oxide synthase in glaucomatous optic neuropathy and pressure-induced optic nerve damage

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12 December 2020

Blood vessels of the glaucomatous optic disc in experimental primate and human eyes

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12 December 2020

The histology of human glaucoma cupping and optic nerve damage: clinicopathologic correlation in 21 eyes

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12 December 2020

Vitreous glutamate concentration and axon loss in monkeys with experimental glaucoma.

1 reference

12 December 2020

Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures. Collaborative Normal-Tension Glaucoma Study Group

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12 December 2020

Gin(kgo) and tonic--with a twist!

1 reference

12 December 2020

Number of ganglion cells in glaucoma eyes compared with threshold visual field tests in the same persons

1 reference

12 December 2020

Enhanced survival and regeneration of axotomized retinal ganglion cells by a mixture of herbal extracts.

1 reference

12 December 2020

Ginkgo biloba extract increases ocular blood flow velocity.

1 reference

12 December 2020

Effect of glatiramer acetate on primary and secondary degeneration of retinal ganglion cells in the rat.

1 reference

12 December 2020

Pharmacological protection of CNS white matter during anoxia: actions of phenytoin, carbamazepine and diazepam.

1 reference

12 December 2020

Influence of topical betaxolol and timolol on visual field in Japanese open-angle glaucoma patients

1 reference

12 December 2020

Effect of Ginkgo biloba extract on preexisting visual field damage in normal tension glaucoma

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12 December 2020

Molecular chaperones, stress proteins and redox homeostasis

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12 December 2020

Use-dependent potentiation of the Nav1.6 sodium channel

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12 December 2020

Activation of caspase 9 in a rat model of experimental glaucoma

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12 December 2020

Fatty acid use in glaucomatous optic neuropathy treatment

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12 December 2020

Activation of caspase-3 in axotomized rat retinal ganglion cells in vivo

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12 December 2020

Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension.

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12 December 2020

TUNEL-positive ganglion cells in human primary open-angle glaucoma.

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12 December 2020

Neuroprotective properties of a synthetic docosanoid, unoprostone isopropyl: clinical benefits in the treatment of glaucoma

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12 December 2020

Müller cell response to laser-induced increase in intraocular pressure in rats

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12 December 2020

The importance of models in glaucoma research

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12 December 2020

Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke

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12 December 2020

Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells

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12 December 2020

Neuroprotection of axons with phenytoin in experimental allergic encephalomyelitis

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12 December 2020

Characterization of activated retinal microglia following optic axotomy

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12 December 2020

Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization

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12 December 2020

Baculoviral IAP repeat-containing-4 protects optic nerve axons in a rat glaucoma model

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12 December 2020

Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice

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12 December 2020

Expression of the mRNA of seven metabotropic glutamate receptors (mGluR1 to 7) in the rat retina. An in situ hybridization study on tissue sections and isolated cells

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12 December 2020

Vitreal glutamate concentration in monkeys with experimental glaucoma.

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12 December 2020

Effect of calcium channel blockers alone and in combination with antiglaucoma medications on intraocular pressure in the primate eye.

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12 December 2020

Role of p38 mitogen-activated protein kinase in axotomy-induced apoptosis of rat retinal ganglion cells.

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12 December 2020

Effects of elevated intraocular pressure on mouse retinal ganglion cells

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12 December 2020

Caspase inhibitors block the retinal ganglion cell death following optic nerve transection

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12 December 2020

The promoter of inducible nitric oxide synthase implicated in glaucoma based on genetic analysis and nuclear factor binding.

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12 December 2020

Role of alpha-2 agonists in neuroprotection

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12 December 2020

Evidence of constriction of optic nerve axons at the lamina cribrosa in the normotensive eye in humans and other mammals

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12 December 2020

The patterns of retinal ganglion cell death in hypertensive eyes

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12 December 2020

Phenytoin blocks retinal ganglion cell death after partial optic nerve crush

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12 December 2020

The toxic effect of sodium L-glutamate on the inner layers of the retina.

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12 December 2020

Systemic reduction in glutathione levels occurs in patients with primary open-angle glaucoma

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12 December 2020

N-methyl-D-aspartate (NMDA)--induced apoptosis in rat retina

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12 December 2020

Protection of the rat retina from ischemic injury by brain-derived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor.

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12 December 2020

Betaxolol attenuates retinal ischemia/reperfusion damage in the rat

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12 December 2020

Prospects for relevant glaucoma models with retinal ganglion cell damage in the rodent eye.

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12 December 2020

From the lab to the clinic: activation of an alpha-2 agonist pathway is neuroprotective in models of retinal and optic nerve injury

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12 December 2020

Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma

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12 December 2020

Direct measurement of free radicals in ischemic/reperfused diabetic rat retina.

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12 December 2020

Ganglion cell death in glaucoma: pathology recapitulates ontogeny

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12 December 2020

Ischemic preconditioning attenuates apoptotic cell death in the rat retina

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12 December 2020

The expression of heat shock protein 27 in retinal ganglion cells in the rat glaucoma model

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12 December 2020

Factors for progression and glaucoma treatment: the Early Manifest Glaucoma Trial

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12 December 2020

Retrograde axoplasmic transport in rat optic nerve in vivo. What causes blockage at increased intraocular pressure?

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12 December 2020

Chronic human glaucoma causing selectively greater loss of large optic nerve fibers

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12 December 2020

NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia

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12 December 2020

Alterations in elastin of the optic nerve head in human and experimental glaucoma

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12 December 2020

Betaxolol, a beta1-adrenoceptor antagonist, has an affinity for L-type Ca2+ channels

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12 December 2020

Transient ischemia of the retina results in massive degeneration of the retinotectal projection: long-term neuroprotection with brimonidine

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12 December 2020

A rat model of chronic pressure-induced optic nerve damage

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12 December 2020

Elevated intraocular pressure and transgenic applications in the mouse

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12 December 2020

MK801-a neuroprotectant in rat hypertensive eyes

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12 December 2020

Levobetaxolol-induced Up-regulation of retinal bFGF and CNTF mRNAs and preservation of retinal function against a photic-induced retinopathy

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12 December 2020

Pathophysiology and treatment of cerebral ischemia.

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12 December 2020

Nitric oxide synthase in the human glaucomatous optic nerve head.

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12 December 2020

Beta 2-adrenergic receptors are expressed by glia in vivo in the normal and injured central nervous system in the rat, rabbit, and human

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12 December 2020

Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced

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12 December 2020

Neuroprotective effects of brain-derived neurotrophic factor in eyes with NMDA-induced neuronal death

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12 December 2020

Pralnacasan (vertex pharmaceuticals).

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12 December 2020

Mechanisms of ischaemic damage to central white matter axons: a quantitative histological analysis using rat optic nerve

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12 December 2020

Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology

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12 December 2020

The distributions of mitochondria and sodium channels reflect the specific energy requirements and conduction properties of the human optic nerve head

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12 December 2020

alpha(2)-Adrenoceptor agonists inhibit vitreal glutamate and aspartate accumulation and preserve retinal function after transient ischemia

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12 December 2020

Isoforms of nitric oxide synthase in the optic nerves of rat eyes with chronic moderately elevated intraocular pressure

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12 December 2020

Optic nerve head structure in glaucoma: astrocytes as mediators of axonal damage

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12 December 2020

Programmed cell death of retinal ganglion cells during experimental glaucoma

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12 December 2020

Survival and axonal regeneration of retinal ganglion cells in adult cats

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12 December 2020

Degeneration of spared axons following partial white matter lesion: implications for optic nerve neuropathies

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12 December 2020

Optic nerve dynein motor protein distribution changes with intraocular pressure elevation in a rat model of glaucoma

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12 December 2020

Comparison of the neuroprotective effects of adrenoceptor drugs in retinal cell culture and intact retina

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12 December 2020

Expression of glutamate receptor genes in the mammalian retina: the localization of GluR1 through GluR7 mRNAs

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12 December 2020

Changes in Thy1 gene expression associated with damaged retinal ganglion cells

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12 December 2020

Factors contributing to neuronal degeneration in retinas of experimental glaucomatous rats

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12 December 2020

Tertiary and quaternary local anesthetics protect CNS white matter from anoxic injury at concentrations that do not block excitability

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12 December 2020

Vasoprotection as neuroprotection for the optic nerve

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12 December 2020

Death and neuroprotection of retinal ganglion cells after different types of injury

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12 December 2020

Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, I: Functional measures

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12 December 2020

Quantitative study of collagen and elastin of the optic nerve head and sclera in human and experimental monkey glaucoma

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12 December 2020

Protective autoimmunity and neuroprotection in inflammatory and noninflammatory neurodegenerative diseases

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12 December 2020

A mouse model of elevated intraocular pressure: retina and optic nerve findings

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12 December 2020

Anterior optic nerve microvascular changes in human glaucomatous optic neuropathy

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12 December 2020

Topically administered timolol and dorzolamide reduce intraocular pressure and protect retinal ganglion cells in a rat experimental glaucoma model

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12 December 2020

Ischemia results 3 months later in altered ERG, degeneration of inner layers, and deafferented tectum: neuroprotection with brimonidine

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12 December 2020

Activation of the glutamate metabotropic receptor protects retina against N-methyl-D-aspartate toxicity

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12 December 2020

Retinal ischemia: mechanisms of damage and potential therapeutic strategies

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12 December 2020

Protective autoimmunity is a physiological response to CNS trauma.

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12 December 2020

Elevated intraocular pressure and optic nerve injury models in the rat.

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12 December 2020

Expression of NMDA and high-affinity kainate receptor subunit mRNAs in the adult rat retina

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12 December 2020

Apoptosis of retinal ganglion cells in anterior ischemic optic neuropathy

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12 December 2020

Expression of small heat shock proteins and intermediate filaments in the human optic nerve head astrocytes exposed to elevated hydrostatic pressure in vitro

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12 December 2020

Autoimmune T cells retard the loss of function in injured rat optic nerves

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12 December 2020

Minocycline delays death of retinal ganglion cells in experimental glaucoma and after optic nerve transection

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12 December 2020

Heat shock proteins, immunity and glaucoma

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12 December 2020

Effectiveness of levobetaxolol and timolol at blunting retinal ischaemia is related to their calcium and sodium blocking activities: relevance to glaucoma

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12 December 2020

Glatiramer acetate: a review of its use in relapsing-remitting multiple sclerosis

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12 December 2020

Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats.

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12 December 2020

Neuroprotective effects of brimonidine against transient ischemia-induced retinal ganglion cell death: a dose response in vivo study

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12 December 2020

The beta-adrenergic receptor antagonist metipranolol blunts zinc-induced photoreceptor and RPE apoptosis

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12 December 2020

Contribution of caspase-8 to apoptosis of axotomized rat retinal ganglion cells in vivo

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12 December 2020

Apoptotic retinal neuronal death by ischemia-reperfusion is executed by two distinct caspase family proteases

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12 December 2020

Topically applied clonidine protects the rat retina from ischaemia/reperfusion by stimulating alpha(2)-adrenoceptors and not by an action on imidazoline receptors

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12 December 2020

In vitro evaluation of reactive astrocyte migration, a component of tissue remodeling in glaucomatous optic nerve head

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12 December 2020

Neuroprotective effect of memantine in different retinal injury models in rats

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12 December 2020

Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger.

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12 December 2020

A rat model for acute rise in intraocular pressure: immune modulation as a therapeutic strategy

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12 December 2020

The role of oxidative stress in glaucoma

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12 December 2020

Caspase inhibitors: a pharmaceutical industry perspective

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12 December 2020

Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage

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12 December 2020

Reperfusion damage following focal ischemia: pathophysiology and therapeutic windows.

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12 December 2020

Calcineurin cleavage is triggered by elevated intraocular pressure, and calcineurin inhibition blocks retinal ganglion cell death in experimental glaucoma

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12 December 2020

Stress proteins in neural cells: functional roles in health and disease

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12 December 2020

Activated microglia in the human glaucomatous optic nerve head

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12 December 2020

Chronology of optic nerve head and retinal responses to elevated intraocular pressure

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12 December 2020

Orthograde and retrograde axoplasmic transport during acute ocular hypertension in the monkey

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12 December 2020

Influence of betaxolol and timolol on the visual fields of patients with glaucoma.

1 reference

12 December 2020

Neuroprotective effects of Ginkgo biloba extract

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12 December 2020

Calcium, ATP, and ROS: a mitochondrial love-hate triangle

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12 December 2020

Apoptotic death of beta cells after optic nerve transection in adult cats.

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12 December 2020

An investigation into the potential mechanisms underlying the neuroprotective effect of clonidine in the retina

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12 December 2020

Functional dichotomy: glutathione and vitamin E in homeostasis relevant to primary open-angle glaucoma

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12 December 2020

Inhibition of caspase activity in retinal cell apoptosis induced by various stimuli in vitro

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12 December 2020

Free radical-mediated effects in reperfusion injury: a histologic study with superoxide dismutase and EGB 761 in rat retina

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12 December 2020

Effects of lomerizine, a calcium channel antagonist, on retinal and optic nerve head circulation in rabbits and humans.

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12 December 2020

The potential of neuroprotection in glaucoma treatment

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12 December 2020

The favorable effect of topical betaxolol and timolol on glaucomatous visual fields: a 2-year follow-up study.

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12 December 2020

The protection of the retina from ischemic injury by the free radical scavenger EGb 761 and zinc in the cat retina.

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12 December 2020

Simvastatin promotes heat shock protein 27 expression and Akt activation in the rat retina and protects axotomized retinal ganglion cells in vivo

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12 December 2020

Experimental glaucoma and optic nerve transection induce simultaneous upregulation of proapoptotic and prosurvival genes.

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12 December 2020

Retinal ganglion cell dysfunction induced by hypoxia and glutamate: potential neuroprotective effects of beta-blockers

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12 December 2020

Metipranolol blunts nitric oxide-induced lipid peroxidation and death of retinal photoreceptors: a comparison with other anti-glaucoma drugs

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12 December 2020

Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human optic nerve head astrocytes

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12 December 2020

An experimental basis for implicating excitotoxicity in glaucomatous optic neuropathy

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12 December 2020

Nitric oxide synthase expression in the transient ischemic rat retina: neuroprotection of betaxolol

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12 December 2020

Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity

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12 December 2020

Morphology of single ganglion cells in the glaucomatous primate retina

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12 December 2020

Memantine protects neurons from shrinkage in the lateral geniculate nucleus in experimental glaucoma

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12 December 2020

Chronic ocular hypertension following episcleral venous occlusion in rats

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12 December 2020

Glaucomatous optic neuropathy: when glia misbehave

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12 December 2020

Dynamic changes in reactive oxygen species and antioxidant levels in retinas in experimental glaucoma

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12 December 2020

Neuroprotective effect of memantine in a rabbit model of optic nerve ischemia

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12 December 2020

Inhibition and recovery of retrograde axoplasmic transport in rat optic nerve during and after elevated IOP in vivo

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12 December 2020

Gene therapy with brain-derived neurotrophic factor as a protection: retinal ganglion cells in a rat glaucoma model.

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12 December 2020

Retinal ganglion cell death in glaucoma: the how, the why, and the maybe.

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12 December 2020

The long-term effects of antiepileptic drugs on the visual system in rats: electrophysiological and histopathological studies

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12 December 2020

Ischemia and reperfusion-induced histologic changes in the rat retina. Demonstration of a free radical-mediated mechanism

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12 December 2020

Blockade of rapid axonal transport. Effect of intraocular pressure elevation in primate optic nerve

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12 December 2020

Retinal glutamate transporter changes in experimental glaucoma and after optic nerve transection in the rat.

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12 December 2020

Protective effects of timolol against the neuronal damage induced by glutamate and ischemia in the rat retina

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12 December 2020

Protective effect of Ginkgo biloba extract (EGB 761) on free radical-induced changes in the electroretinogram of isolated rat retina

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12 December 2020

Effects of axotomy and intraocular administration of NT-4, NT-3, and brain-derived neurotrophic factor on the survival of adult rat retinal ganglion cells. A quantitative in vivo study.

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12 December 2020

Dorzolamide and timolol saves retinal ganglion cells in glaucomatous adult rats.

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12 December 2020

Invited review: Neuroprotective properties of certain beta-adrenoceptor antagonists used for the treatment of glaucoma

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12 December 2020

Molecular determinants of retinal ganglion cell development, survival, and regeneration.

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12 December 2020

The molecular biology of retinal ganglion cell death: caveats and controversies

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12 December 2020

A comparison of the effects of betaxolol, timolol, and pilocarpine on visual function in patients with open-angle glaucoma.

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12 December 2020

Chronic experimental glaucoma in primates. II. Effect of extended intraocular pressure elevation on optic nerve head and axonal transport

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12 December 2020

Memantine reduces alterations to the mammalian retina, in situ, induced by ischemia

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12 December 2020

Up-regulation of brain-derived neurotrophic factor expression by brimonidine in rat retinal ganglion cells

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12 December 2020

Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma

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12 December 2020

Role of alpha-2 adrenergic receptors in neuroprotection and glaucoma

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12 December 2020

The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.

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12 December 2020

N -methyl- D -aspartate (NMDA) induced apoptosis in adult rabbit retinas

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12 December 2020

Effect of diphenylhydantoin on glaucomatous field loss: a preliminary report

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12 December 2020

Expression of nitric oxide synthase-2 (NOS-2) in reactive astrocytes of the human glaucomatous optic nerve head

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12 December 2020

Neuroprotection of retinal ganglion cells by brimonidine in rats with laser-induced chronic ocular hypertension

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12 December 2020

Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis

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12 December 2020

Topical administration of iganidipine, a new water-soluble Ca2+ antagonist, increases ipsilateral optic nerve head circulation in rabbits and cynomolgus monkeys

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12 December 2020

Antigenic specificity of immunoprotective therapeutic vaccination for glaucoma

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12 December 2020

Contrast sensitivity improves after brimonidine therapy in primary open angle glaucoma: a case for neuroprotection.

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12 December 2020

Longterm effect of topical beta-blockers on intraocular pressure and visual field sensitivity in ocular hypertension and chronic open-angle glaucoma

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12 December 2020

Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma

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12 December 2020

Pathophysiology and treatment of focal cerebral ischemia. Part II: Mechanisms of damage and treatment

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12 December 2020

The beta-adrenoceptor antagonists metipranolol and timolol are retinal neuroprotectants: comparison with betaxolol

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12 December 2020

Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model

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12 December 2020

The biochemistry of apoptosis

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12 December 2020

Nitric oxide: a potential mediator of retinal ganglion cell damage in glaucoma

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12 December 2020

Possible role of excitotoxicity in the pathogenesis of glaucoma

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12 December 2020

The effect of experimental glaucoma and optic nerve transection on amacrine cells in the rat retina

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12 December 2020

Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo.

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12 December 2020

T-cell-based vaccination for morphological and functional neuroprotection in a rat model of chronically elevated intraocular pressure.

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12 December 2020

The Low-pressure Glaucoma Treatment Study (LoGTS) study design and baseline characteristics of enrolled patients

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12 December 2020

Direct and indirect approaches to neuroprotective therapy of glaucomatous optic neuropathy

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12 December 2020

Measurement of amino acid levels in the vitreous humor of rats after chronic intraocular pressure elevation or optic nerve transection

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12 December 2020

Histologic changes in the inner retina of albino rats following intravitreal injection of monosodium L-glutamate

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12 December 2020

Human ganglion cells express the alpha-2 adrenergic receptor: relevance to neuroprotection

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12 December 2020

Discordant effects of guanidines on renal structure and function and on regional vascular dysfunction and collagen changes in diabetic rats

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12 December 2020

First-in-class pan caspase inhibitor developed for the treatment of liver disease

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12 December 2020

Optic nerve transection in monkeys may result in secondary degeneration of retinal ganglion cells.

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12 December 2020

In situ detection of apoptosis in normal pressure glaucoma. a preliminary examination

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12 December 2020

Antioxidant effect of a Ginkgo biloba extract (EGb 761) on the retina

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12 December 2020

Evoked expression of the glutamate transporter GLT-1c in retinal ganglion cells in human glaucoma and in a rat model

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12 December 2020

The effects on the intraocular pressure and visual field resulting from a switch in the treatment from timolol to betaxolol

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12 December 2020

Retinal ganglion cells and supporting elements in culture

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12 December 2020

Topically applied betaxolol attenuates NMDA-induced toxicity to ganglion cells and the effects of ischaemia to the retina

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12 December 2020

Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis

1 reference

12 December 2020

Increased expression of iron-regulating genes in monkey and human glaucoma.

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12 December 2020

Neuroprotective effects of nipradilol on purified cultured retinal ganglion cells

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12 December 2020

Serum autoantibodies to heat shock proteins in glaucoma patients from Japan and the United States.

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12 December 2020

Changes in retinal expression of neurotrophins and neurotrophin receptors induced by ocular hypertension

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12 December 2020

Retinal TUNEL-positive cells and high glutamate levels in vitreous humor of mutant quail with a glaucoma-like disorder

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12 December 2020

Activation of the mitochondrial apoptotic pathway in a rat model of central retinal artery occlusion

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12 December 2020

The tissue-specific self-pathogen is the protective self-antigen: the case of uveitis.

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12 December 2020

Distribution of brimonidine into anterior and posterior tissues of monkey, rabbit, and rat eyes

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12 December 2020

Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse model

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12 December 2020

Retinal ganglion cell death in glaucoma: mechanisms and neuroprotective strategies

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12 December 2020

Nitrotyrosine formation and apoptosis in rat models of ocular injury

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12 December 2020

The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration.The AGIS Investigators

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12 December 2020

Effect of intraocular pressure on rapid axoplasmic transport in monkey optic nerve

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12 December 2020

Translimbal laser photocoagulation to the trabecular meshwork as a model of glaucoma in rats

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12 December 2020

Topically applied betaxolol attenuates ischaemia-induced effects to the rat retina and stimulates BDNF mRNA.

1 reference

12 December 2020

Retinal ganglion cell death in experimental glaucoma

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12 December 2020

Glaucoma drops control intraocular pressure and protect optic nerves in a rat model of glaucoma

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12 December 2020

Immunostaining of heat shock proteins in the retina and optic nerve head of normal and glaucomatous eyes.

1 reference

12 December 2020

Functional assessment of glutamate clearance mechanisms in a chronic rat glaucoma model using retinal ganglion cell calcium imaging

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12 December 2020

Differential expression of matrix metalloproteinases in monkey eyes with experimental glaucoma or optic nerve transection

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12 December 2020

Retinal ganglion cell death is delayed by activation of retinal intrinsic cell survival program

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12 December 2020

Alpha-fodrin is cleaved by caspase-3 in a chronic ocular hypertensive (COH) rat model of glaucoma

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12 December 2020

Oxidative stress markers in aqueous humor of glaucoma patients

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12 December 2020

Direct imaging of NMDA-stimulated nitric oxide production in the retina

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12 December 2020

Effects of axonal injury on ganglion cell survival and glutamate homeostasis

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12 December 2020

Distribution of axonal transport blockade by acute intraocular pressure elevation in the primate optic nerve head

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12 December 2020

Neuroprotection in relation to retinal ischemia and relevance to glaucoma

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12 December 2020

Involvement of inflammation, degradation, and apoptosis in a mouse model of glaucoma

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12 December 2020

Nitric oxide synthase-2 in human optic nerve head astrocytes induced by elevated pressure in vitro.

1 reference

12 December 2020

The combined effect of brain-derived neurotrophic factor and a free radical scavenger in experimental glaucoma

1 reference

12 December 2020

Vitreous body glutamate concentration in dogs with glaucoma.

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12 December 2020

[Vitamin E in the complex treatment of patients with primary glaucoma]

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12 December 2020

Retinal neuroprotection by growth factors: a mechanistic perspective

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12 December 2020

Number of people with glaucoma worldwide

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12 December 2020

Neuronal survival after CNS insult is determined by a genetically encoded autoimmune response.

1 reference

12 December 2020

Neuroprotection by sodium channel blockade with phenytoin in an experimental model of glaucoma

1 reference

12 December 2020

Metipranolol attenuates lipid peroxidation in rat brain: a comparative study with other antiglaucoma drugs

1 reference

12 December 2020

A model to study differences between primary and secondary degeneration of retinal ganglion cells in rats by partial optic nerve transection.

1 reference

12 December 2020

T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: possible therapy for optic neuropathies

1 reference

12 December 2020

Protective effects of various antioxidants during ischemia-reperfusion in the rat retina

1 reference

12 December 2020

Therapeutic strategies for normal-tension glaucoma

1 reference

12 December 2020

CNTF promotes survival of retinal ganglion cells after induction of ocular hypertension in rats: the possible involvement of STAT3 pathway

1 reference

12 December 2020

Patterns of retinal ganglion cell survival after brain-derived neurotrophic factor administration in hypertensive eyes of rats

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12 December 2020

Retinal ganglion cell loss is size dependent in experimental glaucoma

1 reference

12 December 2020

Calcium in ischemic cell death

1 reference

12 December 2020

Neuroprotective effect of AIP on N-methyl-D-aspartate-induced cell death in retinal neurons.

1 reference

12 December 2020

Antioxidant intake and primary open-angle glaucoma: a prospective study

1 reference

12 December 2020

Long-term effect of ophthalmic beta-adrenoceptor antagonists on intraocular pressure and retinal sensitivity in primary open-angle glaucoma

1 reference

12 December 2020

Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization

1 reference

12 December 2020

Change in endothelial nitric oxide synthase in the rat retina following transient ischemia

1 reference

12 December 2020

Alpha-2 adrenoceptor agonist protects retinal function after acute retinal ischemic injury in the rat.

1 reference

12 December 2020

[Glutamate in experimental acute elevated intraocular pressure models of rabbits]

1 reference

12 December 2020

Basis of the antiseizure action of phenytoin

1 reference

12 December 2020

Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: implications for glaucoma

1 reference

12 December 2020

Effects of beta-adrenergic blockers on glutamate-induced calcium signals in adult mouse retinal ganglion cells

1 reference

12 December 2020

Glaucoma: thinking in new ways-a rôle for autonomous axonal self-destruction and other compartmentalised processes?

1 reference

12 December 2020

Antioxidant effects of alpha-, gamma- and succinate-tocopherols in guinea pig retina during ischemia-reperfusion injury

1 reference

12 December 2020

Neuroprotective effect of alpha(2) agonist (brimonidine) on adult rat retinal ganglion cells after increased intraocular pressure

1 reference

12 December 2020

New horizons in neuroprotection

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12 December 2020

Neuroprotective effect of nipradilol on axotomized rat retinal ganglion cells

1 reference

12 December 2020

Vitreous concentration of topically applied brimonidine tartrate 0.2%.

1 reference

12 December 2020

Neuroprotective effects of alpha(2)-selective adrenergic agonists against ischemia-induced retinal ganglion cell death

1 reference

12 December 2020

Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, II: Structural measures

1 reference

12 December 2020

Support of retinal ganglion cell survival and axon regeneration by lithium through a Bcl-2-dependent mechanism

1 reference

12 December 2020

Retinal ganglion cell shrinkage in glaucoma

1 reference

12 December 2020

Induction of heat shock protein 72 protects retinal ganglion cells in a rat glaucoma model

1 reference

12 December 2020

Assessment of neuroprotective effects of glutamate modulation on glaucoma-related retinal ganglion cell apoptosis in vivo

1 reference

12 December 2020

Inhibition of caspase-3-like activity reduces glutamate induced cell death in adult rat retina.

1 reference

12 December 2020

The impact of ocular blood flow in glaucoma

1 reference

12 December 2020

Topical flunarizine reduces IOP and protects the retina against ischemia-excitotoxicity.

1 reference

12 December 2020

BDNF enhances retinal ganglion cell survival in cats with optic nerve damage.

1 reference

12 December 2020

Betaxolol, a beta(1)-adrenoceptor antagonist, reduces Na(+) influx into cortical synaptosomes by direct interaction with Na(+) channels: comparison with other beta-adrenoceptor antagonists

1 reference

12 December 2020

Ocular hypotensive action of topical flunarizine in the rabbit: role of sigma 1 recognition sites

1 reference

12 December 2020

The role of heat shock proteins Hsp70 and Hsp27 in cellular protection of the central nervous system.

1 reference

12 December 2020

Apoptosis, neuroprotection, and retinal ganglion cell death: an overview

1 reference

12 December 2020

Autoantibodies to small heat shock proteins in glaucoma.

1 reference

12 December 2020

Vaccination for glaucoma: dream or reality?

1 reference

12 December 2020

Chronic low-dose glutamate is toxic to retinal ganglion cells. Toxicity blocked by memantine

1 reference

12 December 2020

[Lipid peroxidation in the blood of primary glaucoma patients]

1 reference

12 December 2020

Pharmacologic neuroprotection with an inhibitor of nitric oxide synthase for the treatment of glaucoma

1 reference

12 December 2020

The effects of antiglaucoma and systemic medications on ocular blood flow

1 reference

12 December 2020

Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats

1 reference

12 December 2020

Apoptosis of retinal ganglion cells in glaucoma: an update of the molecular pathways involved in cell death

1 reference

12 December 2020

Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts

1 reference

12 December 2020

Effects of a non-selective beta-blocker on adult rat anterograde axonal transport and retinal ganglion layer after increased intraocular pressure

1 reference

12 December 2020

Memantine for dementia

1 reference

12 December 2020

Optic nerve blood flow in glaucoma

1 reference

12 December 2020

Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix.

1 reference

12 December 2020

Neurodegeneration and neuroprotection in glaucoma: development of a therapeutic neuroprotective vaccine: the Friedenwald lecture

1 reference

12 December 2020

Primate glaucoma models

1 reference

12 December 2020

Potential treatment modalities for glaucomatous neuropathy: neuroprotection and neuroregeneration

1 reference

12 December 2020

Suppressive actions of betaxolol on ionic currents in retinal ganglion cells may explain its neuroprotective effects

1 reference

12 December 2020

Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy

1 reference

12 December 2020

White matter injury mechanisms

1 reference

12 December 2020

Ganglion cell death in glaucoma: what do we really know?

1 reference

12 December 2020

Nitric oxide toxicity in CNS white matter: an in vitro study using rat optic nerve

1 reference

12 December 2020

Changes in the collagenous matrix of the aging human lamina cribrosa

1 reference

12 December 2020

Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo does not exclusively depend on phosphatidyl-inositol-3'-kinase/protein kinase B signaling

1 reference

12 December 2020

Timolol concentrations in rat ocular tissues and plasma after topical and intraperitoneal dosing

1 reference

12 December 2020

Scleral biomechanics and glaucoma--a connection?

1 reference

12 December 2020

In vivo and in vitro experiments show that betaxolol is a retinal neuroprotective agent.

1 reference

12 December 2020

Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia

1 reference

12 December 2020

Retinal oxidative stress induced by high intraocular pressure

1 reference

12 December 2020

Comparative effects of antiglaucoma drugs on voltage-dependent calcium channels

1 reference

12 December 2020

Resistance of retinal ganglion cells to an increase in intraocular pressure is immune-dependent.

1 reference

12 December 2020

Understanding mechanisms of pressure-induced optic nerve damage

1 reference

12 December 2020

Mechanistic insights into glaucoma provided by experimental genetics the cogan lecture

1 reference

12 December 2020

Expectations in the treatment of retinal diseases: neuroprotection

1 reference

12 December 2020

Immunolocalization of heat shock proteins in the retina of normal monkey eyes and monkey eyes with laser-induced glaucoma

1 reference

12 December 2020

Free radical scavenging and inhibition of nitric oxide synthase potentiates the neurotrophic effects of brain-derived neurotrophic factor on axotomized retinal ganglion cells In vivo.

1 reference

12 December 2020

1 reference

12 December 2020

The Ginkgo biloba extract (EGb 761) provides a neuroprotective effect on retinal ganglion cells in a rat model of chronic glaucoma

1 reference

12 December 2020

Transcriptional up-regulation and activation of initiating caspases in experimental glaucoma

1 reference

12 December 2020

Protective effects of Ginkgo biloba extract 761 against glutamate-induced neurotoxicity in cultured retinal neuron.

1 reference

12 December 2020

Latanoprost exerts neuroprotective activity in vitro and in vivo

1 reference

12 December 2020

The dynamics and location of axonal transport blockade by acute intraocular pressure elevation in primate optic nerve

1 reference

12 December 2020

Changing antiglaucoma therapy from timolol to betaxolol: effect on ocular blood flow

1 reference

12 December 2020

Neuronal death in glaucoma

1 reference

12 December 2020

A long-lasting hypotensive effect of topical diltiazem on the intraocular pressure in conscious rabbits

1 reference

12 December 2020

Apoptosis in retinal ganglion cell decrease in human glaucomatous eyes

1 reference

12 December 2020

Possible role for memantine in protecting retinal ganglion cells from glaucomatous damage

1 reference

12 December 2020

10.2165/00003495-200767050-00006

Identifiers

DOI

1 reference

Dimensions Publication ID

16 August 2017

1006266812

0 references

1 reference