(Q36929614)

17 August 2017

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title

Thermodynamics of ligand binding to P450 2B4 and P450eryF studied by isothermal titration calorimetry (English)

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17 August 2017

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B K Muralidhara

1

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17 August 2017

James R Halpert

series ordinal

2

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17 August 2017

language of work or name

English

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publication date

1 January 2007

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17 August 2017

published in

Drug Metabolism Reviews

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17 August 2017

volume

39

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17 August 2017

issue

2-3

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17 August 2017

page(s)

539-556

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Heterogeneity of toxicant response: sources of human variability

17 August 2017

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Calorimetric measurement of phospholipid interaction with methyl-beta-cyclodextrin

21 January 2018

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Implications of the allosteric kinetics of cytochrome P450s

21 January 2018

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Homotropic cooperativity of monomeric cytochrome P450 3A4 in a nanoscale native bilayer environment

21 January 2018

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Single-molecule height measurements on microsomal cytochrome P450 in nanometer-scale phospholipid bilayer disks

21 January 2018

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Identification of the binding site on cytochrome P450 2B4 for cytochrome b5 and cytochrome P450 reductase.

21 January 2018

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ITC in the post-genomic era...? Priceless

21 January 2018

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Isothermal titration calorimetry to determine association constants for high-affinity ligands.

21 January 2018

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Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF

21 January 2018

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Resolution of two substrate-binding sites in an engineered cytochrome P450eryF bearing a fluorescent probe

21 January 2018

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An electrostatically driven conformational transition is involved in the mechanisms of substrate binding and cooperativity in cytochrome P450eryF.

21 January 2018

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Kinetics of dithionite-dependent reduction of cytochrome P450 3A4: heterogeneity of the enzyme caused by its oligomerization.

21 January 2018

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Allosteric mechanisms in P450eryF probed with 1-pyrenebutanol, a novel fluorescent substrate

21 January 2018

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Structure and chemistry of cytochrome P450.

21 January 2018

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Directed self-assembly of monodisperse phospholipid bilayer Nanodiscs with controlled size

21 January 2018

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Structural basis for ligand promiscuity in cytochrome P450 3A4.

21 January 2018

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Resolution of multiple substrate binding sites in cytochrome P450 3A4: the stoichiometry of the enzyme-substrate complexes probed by FRET and Job's titration

21 January 2018

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Cytochrome p450 in silico: an integrative modeling approach.

21 January 2018

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Cytochrome P450s and other enzymes in drug metabolism and toxicity

21 January 2018

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Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics

21 January 2018

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A statistical thermodynamic model of the protein ensemble

21 January 2018

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Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4.

21 January 2018

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Structural diversity of human xenobiotic-metabolizing cytochrome P450 monooxygenases

21 January 2018

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Site-directed mutagenesis of cytochrome P450eryF: implications for substrate oxidation, cooperativity, and topology of the active site

21 January 2018

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Homotropic versus heterotopic cooperativity of cytochrome P450eryF: a substrate oxidation and spectral titration study

21 January 2018

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Thermodynamic and biophysical characterization of cytochrome P450 BioI from Bacillus subtilis.

21 January 2018

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Direct measurement of protein binding energetics by isothermal titration calorimetry

21 January 2018

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Human cytochromes P450 associated with the phase 1 metabolism of drugs and other xenobiotics: a compilation of substrates and inhibitors of the CYP1, CYP2 and CYP3 families

21 January 2018

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Crystallization of cytochromes P450 and substrate-enzyme interactions

21 January 2018

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Binding and oxidation of alkyl 4-nitrophenyl ethers by rabbit cytochrome P450 1A2: evidence for two binding sites

21 January 2018

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Conformational flexibility of mammalian cytochrome P450 2B4 in binding imidazole inhibitors with different ring chemistry and side chains. Solution thermodynamics and molecular modeling

21 January 2018

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Can cofactor-binding sites in proteins be flexible? Desulfovibrio desulfuricans flavodoxin binds FMN dimer

21 January 2018

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Crystal structures of the ferrous dioxygen complex of wild-type cytochrome P450eryF and its mutants, A245S and A245T: investigation of the proton transfer system in P450eryF.

21 January 2018

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Overcoming drug resistance in HIV-1 chemotherapy: the binding thermodynamics of Amprenavir and TMC-126 to wild-type and drug-resistant mutants of the HIV-1 protease

21 January 2018

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The thermodynamic landscape of testosterone binding to cytochrome P450 3A4: ligand binding and spin state equilibria

21 January 2018

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NMR studies of ligand binding to P450(eryF) provides insight into the mechanism of cooperativity

21 January 2018

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Crystal structure of human cytochrome P450 2D6

21 January 2018

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Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2

21 January 2018

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Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site

21 January 2018

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Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding

21 January 2018

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An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution

21 January 2018

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Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site.

21 January 2018

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Exact analysis of competition ligand binding by displacement isothermal titration calorimetry.

21 January 2018

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Bench to bedside: Pharmacogenomics, adverse drug interactions, and the cytochrome P450 system

21 January 2018

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Structure of the human lung cytochrome P450 2A13

21 January 2018

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On the value of c: can low affinity systems be studied by isothermal titration calorimetry?

21 January 2018

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Cooperativity in oxidations catalyzed by cytochrome P450 3A4.

21 January 2018

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Peroxo-iron and oxenoid-iron species as alternative oxygenating agents in cytochrome P450-catalyzed reactions: switching by threonine-302 to alanine mutagenesis of cytochrome P450 2B4.

21 January 2018

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Applications of calorimetric methods to drug discovery and the study of protein interactions

21 January 2018

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The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution

21 January 2018

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Crystal structure of human cytochrome P450 2C9 with bound warfarin

21 January 2018

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Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity

21 January 2018

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Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

21 January 2018

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Rapid measurement of binding constants and heats of binding using a new titration calorimeter

21 January 2018

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The human hepatic cytochromes P450 involved in drug metabolism

21 January 2018

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Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen

21 January 2018

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The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530701498182

Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530701498182

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530701498182

Effect of Inorganic Phosphate on FMN Binding and Loop Flexibility in Desulfovibrio desulfuricans Apo-flavodoxin

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530701498182

Thermal Unfolding of Apo and HoloDesulfovibrio desulfuricansFlavodoxin: Cofactor Stabilizes Folded and Intermediate States†

21 January 2018

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10.1080/03602530701498182

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference