(Q37004163)

English

A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases

scientific article published on 06 February 2016

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scholarly article

1 reference

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases (English)

1 reference

Europe PubMed Central

17 August 2017

1 reference

based on heuristic

inferred from title

Jeffery W. Kelly

2

object named as

Jeffery W Kelly

1 reference

Europe PubMed Central

17 August 2017

author name string

Aleksandra Baranczak

1

1 reference

Europe PubMed Central

17 August 2017

publication date

6 February 2016

1 reference

Europe PubMed Central

17 August 2017

Current Opinion in Chemical Biology

1 reference

Europe PubMed Central

17 August 2017

32

1 reference

Europe PubMed Central

17 August 2017

10-21

1 reference

Europe PubMed Central

17 August 2017

Targeting protein aggregation for the treatment of degenerative diseases

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Tafamidis in transthyretin amyloid cardiomyopathy: effects on transthyretin stabilization and clinical outcomes

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Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain

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29 September 2017

The amyloid state and its association with protein misfolding diseases.

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Quantification of transthyretin kinetic stability in human plasma using subunit exchange.

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Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

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c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease

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Role of protein misfolding and proteostasis deficiency in protein misfolding diseases and aging

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29 September 2017

Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy

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29 September 2017

Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases

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29 September 2017

Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments

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29 September 2017

Tafamidis for transthyretin familial amyloid polyneuropathy: a randomized, controlled trial

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29 September 2017

The impact of the unfolded protein response on human disease

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29 September 2017

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

1 reference

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Transthyretin cardiac amyloidoses in older North Americans

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29 September 2017

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

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The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug

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IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin

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29 September 2017

Small-molecule proteostasis regulators for protein conformational diseases

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29 September 2017

Autophagy: renovation of cells and tissues

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29 September 2017

Molecular chaperones in protein folding and proteostasis

1 reference

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29 September 2017

A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin

1 reference

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29 September 2017

Sulfated glycosaminoglycans accelerate transthyretin amyloidogenesis by quaternary structural conversion

1 reference

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29 September 2017

The aging stress response

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29 September 2017

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1 reference

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29 September 2017

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses

1 reference

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29 September 2017

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

1 reference

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29 September 2017

Biological and chemical approaches to diseases of proteostasis deficiency

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29 September 2017

Toward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †

1 reference

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29 September 2017

Toward Optimization of the Linker Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †

1 reference

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29 September 2017

Chemical and biological approaches synergize to ameliorate protein-folding diseases.

1 reference

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29 September 2017

Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis.

1 reference

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29 September 2017

Adapting proteostasis for disease intervention

1 reference

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29 September 2017

Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors

1 reference

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29 September 2017

Signal integration in the endoplasmic reticulum unfolded protein response

1 reference

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29 September 2017

Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis

1 reference

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29 September 2017

The roles of intracellular protein-degradation pathways in neurodegeneration

1 reference

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29 September 2017

Opposing activities protect against age-onset proteotoxicity

1 reference

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29 September 2017

Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

29 September 2017

The pathway by which the tetrameric protein transthyretin dissociates.

1 reference

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29 September 2017

The mammalian unfolded protein response

1 reference

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29 September 2017

Structure of the cross-beta spine of amyloid-like fibrils

1 reference

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29 September 2017

The biological and chemical basis for tissue-selective amyloid disease

1 reference

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29 September 2017

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

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29 September 2017

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

1 reference

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29 September 2017

Therapeutic approaches to protein-misfolding diseases

1 reference

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29 September 2017

A peculiar form of peripheral neuropathy; familiar atypical generalized amyloidosis with special involvement of the peripheral nerves

1 reference

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29 September 2017

Rationalization of the effects of mutations on peptide and protein aggregation rates.

1 reference

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29 September 2017

Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action

1 reference

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29 September 2017

D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis?

1 reference

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29 September 2017

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

1 reference

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29 September 2017

Prevention of transthyretin amyloid disease by changing protein misfolding energetics.

1 reference

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29 September 2017

Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity

1 reference

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29 September 2017

Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis

1 reference

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29 September 2017

The V122I cardiomyopathy variant of transthyretin increases the velocity of rate-limiting tetramer dissociation, resulting in accelerated amyloidosis

1 reference

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29 September 2017

Trans-suppression of misfolding in an amyloid disease.

1 reference

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29 September 2017

Rational design of potent human transthyretin amyloid disease inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

29 September 2017

Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

29 September 2017

Hereditary amyloid cardiomyopathy caused by a variant apolipoprotein A1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

29 September 2017

Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

29 September 2017

Inhibiting transthyretin amyloid fibril formation via protein stabilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

29 September 2017

Familial amyloid polyneuropathy: new developments in genetics and treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

29 September 2017

The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

29 September 2017

Clinical improvement and amyloid regression after liver transplantation in hereditary transthyretin amyloidosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

29 September 2017

Transthyretin: a choroid plexus-specific transport protein in human brain. The 1986 S. Weir Mitchell award

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

29 September 2017

The heat-shock response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

29 September 2017

Fibril in senile systemic amyloidosis is derived from normal transthyretin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

29 September 2017

Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

29 September 2017

Structure of prealbumin: secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

29 September 2017

Autophagy activator promotes neuronal differentiation of adult adipose-derived stromal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

27 June 2018

The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

27 June 2018

Tyrosine kinase inhibition facilitates autophagic SNCA/α-synuclein clearance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

27 June 2018

Broadly applicable methodology for the rapid and dosable small molecule-mediated regulation of transcription factors in human cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

27 June 2018

Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

27 June 2018

The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

27 June 2018

The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

27 June 2018

The evolution of gene expression, structure and function of transthyretin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

27 June 2018

The retinal pigment epithelium is the unique site of transthyretin synthesis in the rat eye

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

27 June 2018

Transthyretin Pro55, a variant associated with early-onset, aggressive, diffuse amyloidosis with cardiac and neurologic involvement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

27 June 2018

Cytoplasmic sphingosine-1-phosphate pathway modulates neuronal autophagy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

4 September 2018

Plasminogen activator inhibitor-1 regulates LPS induced inflammation in rat macrophages through autophagy activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

4 September 2018

A novel tyrosine kinase inhibitor AMN107 (nilotinib) normalizes striatal motor behaviors in a mouse model of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

4 September 2018

Kinetic stabilization of an oligomeric protein by a single ligand binding event

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

4 September 2018

Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

4 September 2018

Transthyretin aggregation under partially denaturing conditions is a downhill polymerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

4 September 2018

Progression of cardiomyopathy after liver transplantation in patients with familial amyloidotic polyneuropathy, Portuguese type.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

4 September 2018

Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907839

4 September 2018

Cardiomyopathy: the importance of recognizing the uncommon diagnosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26859714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovering transthyretin amyloid fibril inhibitors by limited screening

1 reference

https://pubmed.ncbi.nlm.nih.gov/26859714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ten years of international experience with liver transplantation for familial amyloidotic polyneuropathy: results from the Familial Amyloidotic Polyneuropathy World Transplant Registry

1 reference

https://pubmed.ncbi.nlm.nih.gov/26859714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that the amyloid fibril protein in senile systemic amyloidosis is derived from normal prealbumin

1 reference

https://pubmed.ncbi.nlm.nih.gov/26859714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.CBPA.2016.01.009

1 reference

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

17 August 2017

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