(Q37052624)

17 August 2017

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title

Antibody diversification by somatic mutation: from Burnet onwards (English)

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17 August 2017

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Michael S Neuberger

1

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17 August 2017

publication date

8 January 2008

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Immunology & Cell Biology

17 August 2017

published in

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17 August 2017

volume

86

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17 August 2017

issue

2

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17 August 2017

page(s)

124-132

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Men or molecules? A tilt at molecular biology

17 August 2017

cites work

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7 January 2021

Ontogeny of the clonal selection theory of antibody formation. Reflections on Darwin and Ehrlich.

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Genetic approaches to somatic cell variation: summary comment

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Immunological specificity, unique combinations of selected natural globulins provide an alternative to the classical concept.

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Allergy and Immunology

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7 January 2021

Amino acid sequence studies with Bence-Jones proteins

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7 January 2021

Immunoglobulin Structure: Variation in the Sequence of Bence Jones Proteins

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Variations in Amino-Acid Sequence Near the Disulphide Bridges of Bence-Jones Proteins

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7 January 2021

Gamma-Globulin Variability: A Genetic Hypothesis

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7 January 2021

The molecular basis of antibody formation: a paradox

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7 January 2021

Origin of Antibody Variation

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Somatic generation of antibody diversity

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

The V(D)J recombination activating gene, RAG-1.

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

V(D)J recombination: RAG proteins, repair factors, and regulation

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Variability in the Lambda Light Chain Sequences of Mouse Antibody

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Somatic hypermutation

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Codon bias targets mutation.

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Induction of somatic mutation in a human B cell line in vitro

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

AID is essential for immunoglobulin V gene conversion in a cultured B cell line

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

An immunoglobulin mutator that targets G.C base pairs

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Somatic hypermutation: how many mechanisms diversify V region sequences?

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Rearrangement/hypermutation/gene conversion: when, where and why?

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

AID mediates hypermutation by deaminating single stranded DNA.

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Replication protein A interacts with AID to promote deamination of somatic hypermutation targets

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

AID mutant analyses indicate requirement for class-switch-specific cofactors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

An ancient evolutionary origin of the Rag1/2 gene locus

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

DNA deamination mediates innate immunity to retroviral infection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

DNA deamination in immunity: AID in the context of its APOBEC relatives.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Premeiotic instability of repeated sequences in Neurospora crassa

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

A cytosine methyltransferase homologue is essential for repeat-induced point mutation in Neurospora crassa

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100160

7 January 2021

Identifiers

DOI

10.1038/SJ.ICB.7100160

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17 August 2017

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