(Q37137895)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

title

Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

1 reference

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

Senthilkumar S Karuppagounder

16 March 2020

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

author name string

Saurav Brahmachari

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Su Hyun Lee

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Donghoon Kim

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Manoj Kumar

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Xiaobo Mao

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Joo Ho Shin

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Yunjong Lee

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Olga Pletnikova

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Juan C Troncoso

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Valina L Dawson

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Han Seok Ko

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Ted M Dawson

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

language of work or name

English

0 references

publication date

27 June 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

number of pages

19

1 reference

Journal of Clinical Investigation

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

volume

126

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

page(s)

2970-2988

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

16 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4966315/fullTextXML

inferred from PubMed Central ID database lookup

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Tyrosine Kinase Inhibition Regulates Early Systemic Immune Changes and Modulates the Neuroimmune Response in α-Synucleinopathy

14 September 2017

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Cerebrospinal fluid alpha-synuclein as a biomarker for Parkinson's disease diagnosis: a systematic review and meta-analysis.

14 September 2017

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The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease

14 September 2017

1 reference

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14 September 2017

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Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA.

14 September 2017

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Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease

14 September 2017

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c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease

14 September 2017

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Parkin plays a role in sporadic Parkinson's disease

14 September 2017

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Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss

14 September 2017

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Alpha-synuclein post-translational modifications as potential biomarkers for Parkinson disease and other synucleinopathies

14 September 2017

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Neuroprotective efficacy of a new brain-penetrating C-Abl inhibitor in a murine Parkinson's disease model

14 September 2017

1 reference

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The role of Ser129 phosphorylation of α-synuclein in neurodegeneration of Parkinson's disease: a review of in vivo models

14 September 2017

1 reference

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Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

14 September 2017

1 reference

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Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities

14 September 2017

1 reference

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Animal models of Parkinson's disease: vertebrate genetics

14 September 2017

1 reference

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Nonmotor symptoms in Parkinson's disease in 2012: relevant clinical aspects

14 September 2017

1 reference

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Animal models of Parkinson's disease: limits and relevance to neuroprotection studies.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

Biochemical increase in phosphorylated alpha-synuclein precedes histopathology of Lewy-type synucleinopathies

14 September 2017

1 reference

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Phosphorylated α-synuclein in Parkinson's disease

14 September 2017

1 reference

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Modelling of Parkinson's disease in mice

14 September 2017

1 reference

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Recent advances in the genetics of Parkinson's disease

14 September 2017

1 reference

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PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

14 September 2017

1 reference

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Genetic animal models of Parkinson's disease

14 September 2017

1 reference

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Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model

14 September 2017

1 reference

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Extended kinase profile and properties of the protein kinase inhibitor nilotinib

14 September 2017

1 reference

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Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration

14 September 2017

1 reference

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Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery

14 September 2017

1 reference

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Diagnosis and treatment of Parkinson disease: molecules to medicine

14 September 2017

1 reference

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Alpha-synuclein and transgenic mouse models

14 September 2017

1 reference

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Loss of locus coeruleus neurons and reduced startle in parkin null mice

14 September 2017

1 reference

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

14 September 2017

1 reference

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Regulation of the c-Abl and Bcr-Abl tyrosine kinases

14 September 2017

1 reference

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JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease

14 September 2017

1 reference

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Parkinson's disease: mechanisms and models

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

The role of alpha-synuclein in Parkinson's disease: insights from animal models

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

alpha-Synuclein is phosphorylated in synucleinopathy lesions

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

Alpha-synuclein and neurodegenerative diseases

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

Direct database searching with MALDI-PSD spectra of peptides

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

Tyrosine kinase inhibition facilitates autophagic SNCA/α-synuclein clearance

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of α-synuclein in Parkinson's disease models

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

The impact of graft size on the development of dyskinesia following intrastriatal grafting of embryonic dopamine neurons in the rat.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

A novel tyrosine kinase inhibitor AMN107 (nilotinib) normalizes striatal motor behaviors in a mouse model of Parkinson's disease

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

100 years of Lewy pathology

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

Enhanced BCR-ABL kinase inhibition does not result in increased inhibition of downstream signaling pathways or increased growth suppression in CML progenitors

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

Integrin-mediated dendrite branch maintenance requires Abelson (Abl) family kinases.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966315

Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27348587

12 December 2020

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/27348587

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1172/JCI85456

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348587%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

PubMed publication ID

27348587

1 reference