(Q37139779)

English

PTEN in brain tumors

scientific article published on April 2008

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

1 reference

Europe PubMed Central

PTEN in brain tumors (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

Daphne Haas-Kogan

1

object named as

Daphne Haas-Kogan

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

2

object named as

David Stokoe

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

publication date

1 April 2008

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

599-610

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

Loss of heterozygosity for 10q loci in human gliomas

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Genetic pathways to glioblastoma: a population-based study

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

PTEN: one gene, many syndromes

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Cancer phenomics: RET and PTEN as illustrative models

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Acute regulation of the tumour suppressor phosphatase, PTEN, by anionic lipids and reactive oxygen species

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Signalling through Class I PI3Ks in mammalian cells

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https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

The phosphoinositide 3-kinase pathway and cancer

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Physiological functions of protein kinase B/Akt

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

PTEN and myotubularin: novel phosphoinositide phosphatases

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

PIK3CA alterations in primary (de novo) and secondary glioblastomas.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Cell cycle arrest by the PTEN tumor suppressor is target cell specific and may require protein phosphatase activity

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Regulation of cell migration by the C2 domain of the tumor suppressor PTEN.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Protein phosphatase activity of PTEN inhibited the invasion of glioma cells with epidermal growth factor receptor mutation type III expression.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Mechanistic insights into maintenance of high p53 acetylation by PTEN.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Regulation of PTEN transcription by p53

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

p53 down-regulates phosphatase and tensin homologue deleted on chromosome 10 protein stability partially through caspase-mediated degradation in cells with proteasome dysfunction

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

TOJ3, a target of the v-Jun transcription factor, encodes a protein with transforming activity related to human microspherule protein 1 (MCRS1).

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endotheli

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Histone deacetylase inhibitor trichostatin a potentiates doxorubicin-induced apoptosis by up-regulating PTEN expression

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Inhibition of in vivo glioma growth and invasion by peroxisome proliferator-activated receptor gamma agonist treatment.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Activators of the nuclear receptor PPARgamma enhance colon polyp formation

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Association between cancer prevalence and use of thiazolidinediones: results from the Vermont Diabetes Information System

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

c-Jun promotes cellular survival by suppression of PTEN.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Direct identification of PTEN phosphorylation sites

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Regulation of PTEN by Rho small GTPases

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Reversible inactivation of the tumor suppressor PTEN by H2O2

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

The redox regulation of PI 3-kinase-dependent signaling

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Membrane-binding and activation mechanism of PTEN.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

NHERFs, NEP, MAGUKs, and more: interactions that regulate PTEN.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

PTEN/MMAC1 expression in melanoma resection specimens

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Vaults: a ribonucleoprotein particle involved in drug resistance?

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Ubiquitination regulates PTEN nuclear import and tumor suppression

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Loss of chromosome 10 is an independent prognostic factor in high-grade gliomas

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Analysis of loss of heterozygosity on chromosome 10 in patients with malignant astrocytic tumors: correlation with patient age and survival.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Biomarkers to predict response to epidermal growth factor receptor inhibitors

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Over-expression of PTEN sensitizes human ovarian cancer cells to cisplatin-induced apoptosis in a p53-dependent manner

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

The epidemiology of autism: a review.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

PTEN mutation in a family with Cowden syndrome and autism

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Will the real Cowden syndrome please stand up (again)? Expanding mutational and clinical spectra of the PTEN hamartoma tumour syndrome

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Pten regulates neuronal arborization and social interaction in mice

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

PTEN couples Sema3A signalling to growth cone collapse.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Effect of the Alzheimer amyloid fragment Abeta(25-35) on Akt/PKB kinase and survival of PC12 cells

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Isoelectric focusing technology quantifies protein signaling in 25 cells.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Identification of magnetic resonance detectable metabolic changes associated with inhibition of phosphoinositide 3-kinase signaling in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

PTEN Autoregulates Its Expression by Stabilization of p53 in a Phosphatase-Independent Manner

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas

1 reference

https://api.crossref.org/works/10.1586%2F14737175.8.4.599

21 January 2018

Identifiers

10.1586/14737175.8.4.599

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

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