(Q37174527)

English

Inhibitory effect of PACAP on caspase activity in neuronal apoptosis: a better understanding towards therapeutic applications in neurodegenerative diseases.

scientific article published on 28 May 2008

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8 January 2020

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Inhibitory effect of PACAP on caspase activity in neuronal apoptosis: a better understanding towards therapeutic applications in neurodegenerative diseases (English)

1 reference

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8 January 2020

apoptotic process

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neurodegeneration

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Valérie Jolivel

2

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8 January 2020

Agnieszka Dejda

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Agnieszka Dejda

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8 January 2020

4

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Tommy Seaborn

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8 January 2020

author name string

Steve Bourgault

3

1 reference

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8 January 2020

Alain Fournier

5

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8 January 2020

Hubert Vaudry

6

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8 January 2020

David Vaudry

7

1 reference

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8 January 2020

publication date

28 May 2008

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8 January 2020

Journal of Molecular Neuroscience

1 reference

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8 January 2020

36

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8 January 2020

1-3

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8 January 2020

26-37

1 reference

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8 January 2020

https://scigraph.springernature.com/pub.10.1007/s12031-008-9087-1

0 references

Cloning and characterization of rat caspase-9: implications for a role in mediating caspase-3 activation and hippocampal cell death after transient cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-008-9087-1

21 January 2018

Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-008-9087-1

21 January 2018

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1 reference

https://api.crossref.org/works/10.1007%2FS12031-008-9087-1

21 January 2018

Mice deficient in interleukin-1 converting enzyme are resistant to neonatal hypoxic-ischemic brain damage

1 reference

https://api.crossref.org/works/10.1007%2FS12031-008-9087-1

21 January 2018

Transient global forebrain ischemia induces a prolonged expression of the caspase-3 mRNA in rat hippocampal CA1 pyramidal neurons.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-008-9087-1

21 January 2018

Synthesis and spasmolytic action of 2-substituted thienopyrimidin-4-one derivatives

1 reference

https://api.crossref.org/works/10.1007%2FS12031-008-9087-1

21 January 2018

Reduced ischemic brain injury in interleukin-1 beta converting enzyme-deficient mice.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-008-9087-1

21 January 2018

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis induced by endoplasmic reticulum stress depends on activation of caspase-3 via caspase-12.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary adenylate cyclase-activating polypeptide inhibits caspase-3 activity but does not protect cerebellar granule neurons against beta-amyloid (25-35)-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery and SAR of hydrazide antagonists of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor type 1 (PAC1-R).

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-3 mediated neuronal death after traumatic brain injury in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Passage of pituitary adenylate cyclase activating polypeptide1-27 and pituitary adenylate cyclase activating polypeptide1-38 across the blood-brain barrier.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspases and receptor cleavage

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin inhibits caspase-3 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PACAP-38 protects cerebellar granule cells from apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delayed systemic administration of PACAP38 is neuroprotective in transient middle cerebral artery occlusion in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary adenylate cyclase-activating polypeptide protects rat-cultured cortical neurons from glutamate-induced cytotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of intravenous PACAP38 on cerebral hemodynamics in healthy volunteers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary adenylate cyclase activating polypeptide reduces A-type K+ currents and caspase activity in cultured adult mouse olfactory neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex I inhibitor, rotenone

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PACAP protects cerebellar granule neurons against oxidative stress-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific caspase inhibitor Q-VD-OPh prevents neonatal stroke in P7 rat: a role for gender.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of pituitary adenylate cyclase activating polypeptide in a rat model of traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary adenylate cyclase activating polypeptide protects dopaminergic neurons and improves behavioral deficits in a rat model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of ICE slows ALS in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary adenylate cyclase-activating polypeptide prevents cell death in the spinal cord with traumatic injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary adenylate cyclase-activating polypeptide is up-regulated in cortical pyramidal cells after focal ischemia and protects neurons from mild hypoxic/ischemic damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PACAP protects hippocampal neurons against apoptosis: involvement of JNK/SAPK signaling pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pulmonary and systemic effects of inhaled PACAP38 in healthy male subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptidyl-peptidase IV (CD26)--role in the inactivation of regulatory peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The CD95(APO-1/Fas) DISC and beyond

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary adenylate cyclase-activating polypeptide (PACAP) prevents hippocampal neurons from apoptosis by inhibiting JNK/SAPK and p38 signal transduction pathways.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid desensitization of receptors for pituitary adenylate cyclase-activating polypeptide (PACAP) in chick cerebral cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perspectives on pituitary adenylate cyclase activating polypeptide (PACAP) in the neuroendocrine, endocrine, and nervous systems.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of caspase-12 by endoplasmic reticulum stress induced by transient middle cerebral artery occlusion in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspases: enemies within

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human VIP-alpha: a long-acting, biocompatible and biodegradable peptide nanomedicine for essential hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential requirement for caspase 9 in apoptotic pathways in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary adenylate cyclase activating polypeptide prevents apoptosis in cultured cerebellar granule neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Action of pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide on the rat vascular system: effects on blood pressure and receptor binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective potential of three neuropeptides PACAP, VIP and PHI.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural requirements for the occupancy of pituitary adenylate-cyclase-activating-peptide (PACAP) receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes. Discovery of PACAP(6-38) as a potent antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary adenylate cyclase-activating polypeptide protects rat cerebellar granule neurons against ethanol-induced apoptotic cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-12 and caspase-4 are not required for caspase-dependent endoplasmic reticulum stress-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of caspase-3 in beta-amyloid-induced apoptosis of cultured rat cortical neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuropeptide PACAP attenuates beta-amyloid (1-42)-induced toxicity in PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: a structural basis for specific adaptor/caspase interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alteration of caspases and apoptosis-related proteins in brains of patients with Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dimeric Smac/diablo peptide directly relieves caspase-3 inhibition by XIAP. Dynamic and cooperative regulation of XIAP by Smac/Diablo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling pathways for PC12 cell differentiation: making the right connections

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization and characterization of PACAP receptors in the rat cerebellum during development: evidence for a stimulatory effect of PACAP on immature cerebellar granule cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ontogeny of pituitary adenylate cyclase-activating polypeptide (PACAP) and its binding sites in the rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of ischemia-induced death of hippocampal neurons by pituitary adenylate cyclase activating polypeptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PACAP and C2-ceramide generate different AP-1 complexes through a MAP-kinase-dependent pathway: involvement of c-Fos in PACAP-induced Bcl-2 expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PACAP inhibits delayed rectifier potassium current via a cAMP/PKA transduction pathway: evidence for the involvement of I k in the anti-apoptotic action of PACAP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3'-OH kinase and protein kinase A pathways mediate the anti-apoptotic effect of pituitary adenylyl cyclase-activating polypeptide in cultured cerebellar granule neurons: modulation by ethanol.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling cascades involved in neuroprotection by subpicomolar pituitary adenylate cyclase-activating polypeptide 38.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human ICE/CED-3 protease nomenclature

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection by endogenous and exogenous PACAP following stroke.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel cyclic AMP-dependent Epac-Rit signaling pathway contributes to PACAP38-mediated neuronal differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) on the cardiovascular system in sheep

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposite regulation of the mitochondrial apoptotic pathway by C2-ceramide and PACAP through a MAP-kinase-dependent mechanism in cerebellar granule cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The CASBAH: a searchable database of caspase substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulators of cerebellar granule cell development act through specific signaling pathways.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclic AMP and pituitary adenylate cyclase-activating polypeptide (PACAP) prevent programmed cell death of cultured rat cerebellar granule cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RAIDD is a new 'death' adaptor molecule

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary adenylate cyclase-activating polypeptide (PACAP-38) protects cerebellar granule neurons from apoptosis by activating the mitogen-activated protein kinase (MAP kinase) pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary adenylate cyclase‐activating polypeptide prevents C2‐ceramide‐induced apoptosis of cerebellar granule cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ontogeny of pituitary adenylate cyclase-activating polypeptide (PACAP) receptors in the rat cerebellum: a quantitative autoradiographic study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysequilibrium between caspases and their inhibitors in a mouse model for amyotrophic lateral sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upstream control of apoptosis by caspase-2 in serum-deprived primary neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of pretreatment with PACAP on the infarct size and functional outcome in rat permanent focal cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dimer formation drives the activation of the cell death protease caspase 9

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effects of PACAP in excitotoxic striatal lesion

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic control of programmed cell death in the nematode C. elegans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophic activity of pituitary adenylate cyclase-activating polypeptide on rat cerebellar cortex during development

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-2 mediates neuronal cell death induced by beta-amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of post-traumatic brain injury and free radical production by inhibition of the caspase-1 cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Encapsulation of vasoactive intestinal peptide into liposomes: effects on vasodilation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical and biochemical assessment of caspase-3 activation and DNA fragmentation following transient focal ischemia in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increases in Bcl-2 and cleavage of caspase-1 and caspase-3 in human brain after head injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intravenous infusion of pituitary adenylate cyclase-activating polypeptide (PACAP) in a patient with multiple myeloma and myeloma kidney: a case study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebellar cortical-layer-specific control of neuronal migration by pituitary adenylate cyclase-activating polypeptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective caspase activation may contribute to neurological dysfunction after experimental spinal cord trauma

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of dipeptidyl peptidase IV in the cleavage of glucagon family peptides: in vivo metabolism of pituitary adenylate cyclase activating polypeptide-(1-38).

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered cerebellar development in mice lacking pituitary adenylate cyclase-activating polypeptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel stable PACAP analogs with potent activity towards the PAC1 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interdimer processing and linearity of procaspase-3 activation. A unifying mechanism for the activation of initiator and effector caspases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuroprotective effects of PACAP in monosodium glutamate-induced retinal lesion involve inhibition of proapoptotic signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pro-caspase-3 is a major physiologic target of caspase-8.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PACAP protects neuronal PC12 cells from the cytotoxicity of human prion protein fragment 106-126.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

X-linked IAP is a direct inhibitor of cell-death proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary adenylate cyclase-activating polypeptide stimulates both c-fos gene expression and cell survival in rat cerebellar granule neurons through activation of the protein kinase A pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of caspase-8 in the Alzheimer's disease brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of caspase-mediated apoptosis to the cell death caused by oxygen-glucose deprivation in cortical cell cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary adenylate cyclase-activating polypeptide promotes cell survival and neurite outgrowth in rat cerebellar neuroblasts.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteases for cell suicide: functions and regulation of caspases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postinjury administration of pituitary adenylate cyclase activating polypeptide (PACAP) attenuates traumatically induced axonal injury in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The parkinsonian neurotoxin rotenone activates calpain and caspase-3 leading to motoneuron degeneration in spinal cord of Lewis rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Bcl-2 protein family: arbiters of cell survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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