(Q37199641)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18577998%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

review article

1 reference

title

Drug insight: aggrecanases as therapeutic targets for osteoarthritis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18577998%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18577998%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Christopher B Little

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18577998%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1

Amanda J Fosang

1 reference

18 August 2017

Christopher B Little

2

1 reference

18 August 2017

24 June 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18577998%20AND%20SRC:MED&resulttype=core&format=json

Nature Clinical Practice Rheumatology

9 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18577998%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

volume

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18577998%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18577998%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

page(s)

420-427

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18577998%20AND%20SRC:MED&resulttype=core&format=json

G1-G2 aggrecan product that can be generated by M-calpain on truncation at Ala709-Ala710 is present abundantly in human articular cartilage.

9 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

Chondrocyte-mediated catabolism of aggrecan: aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

ADAMTS-5: the story so far.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Will the real aggrecanase(s) step up: evaluating the criteria that define aggrecanase activity in osteoarthritis.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Kinetics of aggrecanase- and metalloproteinase-induced neoepitopes in various stages of cartilage destruction in murine arthritis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Role of aggrecanase 1 in Lyme arthritis.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Evidence of a novel aggrecan-degrading activity in cartilage: Studies of mice deficient in both ADAMTS-4 and ADAMTS-5.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Global analyses of gene expression in early experimental osteoarthritis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Aggrecanolysis in human osteoarthritis: confocal localization and biochemical characterization of ADAMTS5–hyaluronan complexes in articular cartilages

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic cartilage

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Hyaluronan synthesis and degradation in cartilage and bone

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Risk factors for the incidence and progression of radiographic knee osteoarthritis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Osteoarthritis of the knee joint: an eight year prospective study

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Radiological progression of osteoarthritis: an 11 year follow up study of the knee

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Glucosamine for pain in osteoarthritis: why do trial results differ?

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

The efficacy of glucosamine sulfate in osteoarthritis: financial and nonfinancial conflict of interest.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

OARSI recommendations for the management of hip and knee osteoarthritis, part I: critical appraisal of existing treatment guidelines and systematic review of current research evidence

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Effects of glucosamine and chondroitin sulfate on bovine cartilage explants under long-term culture conditions.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Synovial and plasma glucosamine concentrations in osteoarthritic patients following oral crystalline glucosamine sulphate at therapeutic dose

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

The pathobiology of osteoarthritis and the rationale for the use of pentosan polysulfate for its treatment

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Production of tissue inhibitor of metalloproteinases 3 is selectively enhanced by calcium pentosan polysulfate in human rheumatoid synovial fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Calcium pentosan polysulfate inhibits the catabolism of aggrecan in articular cartilage explant cultures

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Effects of pentosan polysulfate in osteoarthritis of the knee: A randomized, double-blind, placebo-controlled pilot study

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

A meta-analysis of controlled clinical studies with diacerein in the treatment of osteoarthritis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Diacerhein treatment reduces the severity of osteoarthritis in the canine cruciate-deficiency model of osteoarthritis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Rhein, an active metabolite of diacerein, suppresses the interleukin-1alpha-induced proteoglycan degradation in cultured rabbit articular chondrocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Diacerhein and rhein prevent interleukin-1beta-induced nuclear factor-kappaB activation by inhibiting the degradation of inhibitor kappaB-alpha.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Cyclosporin A inhibition of aggrecanase-mediated proteoglycan catabolism in articular cartilage

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Calcineurin modulates the catabolic and anabolic activity of chondrocytes and participates in the progression of experimental osteoarthritis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

A clinical trial of cyclosporine G in cadaveric renal transplantation.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

DNA methylation in osteoarthritic chondrocytes: a new molecular target

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0841

7 January 2021

Identifiers

DOI

10.1038/NCPRHEUM0841

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18577998%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference