(Q37451552)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19379082%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

review article

1 reference

title

mTOR in renal cell cancer: modulator of tumor biology and therapeutic target (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19379082%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

1

Piotr J Wysocki

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19379082%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

publication date

1 April 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19379082%20AND%20SRC:MED&resulttype=core&format=json

Expert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcare

26 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19379082%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19379082%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

page(s)

231-241

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19379082%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19379082%20AND%20SRC:MED&resulttype=core&format=json

The epidemiology of renal cell carcinoma

26 January 2020

cites work

1 reference

21 January 2018

Cancer statistics, 2008

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Global increases in kidney cancer incidence, 1973-1992.

21 January 2018

1 reference

21 January 2018

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Recent developments in renal cell cancer immunotherapy

21 January 2018

1 reference

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

21 January 2018

Protein kinase C delta

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Distinctive activation mechanisms and functions for protein kinase Cdelta

21 January 2018

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The MAPK signalling pathways and colorectal cancer

21 January 2018

1 reference

VEGF and VEGFR-1 are coexpressed by epithelial and stromal cells of renal cell carcinoma.

21 January 2018

1 reference

Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer

21 January 2018

1 reference

The IRS-signalling system: a network of docking proteins that mediate insulin action

21 January 2018

1 reference

PKB/AKT: functional insights from genetic models

21 January 2018

1 reference

Akt activation by growth factors is a multiple-step process: the role of the PH domain

21 January 2018

1 reference

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

1 reference

Oncogenic kinase signalling

21 January 2018

1 reference

TOR, a central controller of cell growth

21 January 2018

1 reference

TOR signalling and control of cell growth

21 January 2018

1 reference

Current development of mTOR inhibitors as anticancer agents

21 January 2018

1 reference

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

21 January 2018

1 reference

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

1 reference

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

1 reference

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

An expanding role for mTOR in cancer

21 January 2018

1 reference

The expanding TOR signaling network

21 January 2018

1 reference

Mammalian target of rapamycin inhibition as a therapeutic strategy in the management of urologic malignancies

21 January 2018

1 reference

United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling

21 January 2018

1 reference

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

21 January 2018

1 reference

Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels

21 January 2018

1 reference

Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.

21 January 2018

1 reference

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

21 January 2018

1 reference

Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2.

21 January 2018

1 reference

Intracellular signal transduction pathway proteins as targets for cancer therapy.

21 January 2018

1 reference

Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes.

21 January 2018

1 reference

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

21 January 2018

1 reference

Analysis of insulin-like growth factors and insulin-like growth factor I receptor expression in renal cell carcinoma.

21 January 2018

1 reference

The prognostic significance of epidermal growth factor receptor expression in clear-cell renal cell carcinoma: a call for standardized methods for immunohistochemical evaluation

21 January 2018

1 reference

Loss of tumor suppressor protein PTEN during renal carcinogenesis.

21 January 2018

1 reference

PTEN expression in renal cell carcinoma and oncocytoma and prognosis

21 January 2018

1 reference

The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling

21 January 2018

1 reference

The coordinate regulation of the p53 and mTOR pathways in cells

21 January 2018

1 reference

The tuberous sclerosis complex genes in tumor development

21 January 2018

1 reference

PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR

21 January 2018

1 reference

Hypoxia-inducible factors: central regulators of the tumor phenotype

21 January 2018

1 reference

Purification and characterization of hypoxia-inducible factor 1

21 January 2018

1 reference

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

21 January 2018

1 reference

Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1): a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells.

21 January 2018

1 reference

Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt

21 January 2018

1 reference

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

21 January 2018

1 reference

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

1 reference

The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake

21 January 2018

1 reference

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

21 January 2018

1 reference

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

21 January 2018

1 reference

Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.

21 January 2018

1 reference

Collagenase expression and activity is modulated by the interaction of collagen types, hypoxia, and nutrition in human lung cells.

21 January 2018

1 reference

RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis

21 January 2018

1 reference

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

21 January 2018

1 reference

Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression.

21 January 2018

1 reference

PDGF receptor kinase inhibitors for the treatment of PDGF driven diseases

21 January 2018

1 reference

Targeting HIF-1 for cancer therapy

21 January 2018

1 reference

HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.

21 January 2018

1 reference

Intracellular signaling in tumor and endothelial cells: The expected and, yet again, the unexpected

21 January 2018

1 reference

Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

21 January 2018

1 reference

Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling

21 January 2018

1 reference

The effects of mTOR-Akt interactions on anti-apoptotic signaling in vascular endothelial cells

21 January 2018

1 reference

Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.

21 January 2018

1 reference

The Akt-mTOR tango and its relevance to cancer

21 January 2018

1 reference

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

21 January 2018

1 reference

Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

21 January 2018

1 reference

Rapamycin reduces hybridoma cell death and enhances monoclonal antibody production

21 January 2018

1 reference

Use of rapamycin-impregnated stents in coronary arteries

21 January 2018

1 reference

mTOR-targeted therapy of cancer with rapamycin derivatives

21 January 2018

1 reference

Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma

21 January 2018

1 reference

Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial

21 January 2018

1 reference

Potential histologic and molecular predictors of response to temsirolimus in patients with advanced renal cell carcinoma

21 January 2018

1 reference

Captopril, an angiotensin-converting enzyme inhibitor, promotes growth of immunogenic tumors in mice.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1586/ERM.09.8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19379082%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

1 reference