(Q37481066)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19441060%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

review article

1 reference

title

Simple vertebrate models for chemical genetics and drug discovery screens: lessons from zebrafish and Xenopus (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19441060%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

0 references

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19441060%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

author name string

Grant N Wheeler

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19441060%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

publication date

1 June 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19441060%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

published in

Developmental Dynamics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19441060%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

volume

238

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19441060%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

page(s)

1287-1308

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19441060%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19441060%20AND%20SRC:MED&resulttype=core&format=json

Identification of a novel protein regulating microtubule stability through a chemical approach

28 January 2020

cites work

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Role of AMP-activated protein kinase in mechanism of metformin action

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Inverse drug screens: a rapid and inexpensive method for implicating molecular targets

21 January 2018

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7 January 2021

Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates

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7 January 2021

H+ pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration.

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7 January 2021

Tagged small molecule library approach for facilitated chemical genetics

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7 January 2021

Lymphangiogenesis in development and human disease

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7 January 2021

Mining the Wnt pathway for cancer therapeutics

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https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

The role of zebrafish in chemical genetics

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7 January 2021

Target identification in chemical genetics: the (often) missing link

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7 January 2021

High-throughput assay for small molecules that modulate zebrafish embryonic heart rate.

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7 January 2021

Angiogenesis in health and disease

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7 January 2021

Dissection of angiogenic signaling in zebrafish using a chemical genetic approach

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7 January 2021

Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila

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7 January 2021

Retinoic acid signaling is essential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus

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7 January 2021

Gene expression analysis defines the proximal tubule as the compartment for endocytic receptor-mediated uptake in the Xenopus pronephric kidney

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7 January 2021

Screening of FGF target genes in Xenopus by microarray: temporal dissection of the signalling pathway using a chemical inhibitor

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7 January 2021

Analysis of the activity of DNA, RNA, and protein synthesis inhibitors on Xenopus embryo development

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7 January 2021

Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

New insights into the molecular control of the lymphatic vascular system and its role in disease

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

The immunoglobulin heavy-chain locus in zebrafish: identification and expression of a previously unknown isotype, immunoglobulin Z

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

A genomic regulatory network for development

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibition

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Chemical genetics reveals a complex functional ground state of neural stem cells.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

The immune system of invertebrates and vertebrates

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

The immune system of Xenopus

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Adaptive evolution in zinc finger transcription factors

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Development of a metabolic activation system for the frog embryo teratogenesis assay: Xenopus (FETAX).

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Evaluation of the developmental toxicity of thalidomide using frog embryo teratogenesis assay-xenopus (FETAX): biotransformation and detoxification.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Serotonin transporter function is an early step in left-right patterning in chick and frog embryos

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Genome sequence of the Brown Norway rat yields insights into mammalian evolution

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Genetic screens for mutations affecting development of Xenopus tropicalis

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Dissecting cell biology with chemical scalpels

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Beta-catenin signaling activity dissected in the early Xenopus embryo: a novel antisense approach

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

The origin and evolution of model organisms

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Genomics. Vertebrate genomes compared.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Accelerated gene evolution and subfunctionalization in the pseudotetraploid frog Xenopus laevis

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Artery/vein specification is governed by opposing phosphatidylinositol-3 kinase and MAP kinase/ERK signaling

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Identification of the F1F0 mitochondrial ATPase as a target for modulating skin pigmentation by screening a tagged triazine library in zebrafish

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

An in vivo chemical library screen in Xenopus tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Genetic analysis of melanophore development in zebrafish embryos.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Pilot morpholino screen in Xenopus tropicalis identifies a novel gene involved in head development

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Facilitated forward chemical genetics using a tagged triazine library and zebrafish embryo screening

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

The descent of the antibody-based immune system by gradual evolution

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

A restrictive role for Hedgehog signalling during otic specification in Xenopus

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

A novel cell-free screen identifies a potent inhibitor of the Fanconi anemia pathway

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Asymmetries in H+/K+-ATPase and cell membrane potentials comprise a very early step in left-right patterning

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Animal models of human disease: zebrafish swim into view

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Drug-like properties and the causes of poor solubility and poor permeability

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

A small-molecule agonist of the Wnt signaling pathway

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) using the Frog Embryo Teratogenesis Assay-Xenopus (FETAX).

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Overcoming the gridlock in discovery research

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Unraveling tissue regeneration pathways using chemical genetics

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

GSK-3-selective inhibitors derived from Tyrian purple indirubins

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Genetics of programmed cell death in C. elegans: past, present and future.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Drugs that induce repolarization abnormalities cause bradycardia in zebrafish

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Forward chemical genetic approach identifies new role for GAPDH in insulin signaling

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Evaluation of zebrafish embryos as a model for assessing inhibition of hERG.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Reverse genetics in zebrafish by TILLING.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

The morphology of heart development in Xenopus laevis.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Small molecule screening in the zebrafish

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

A chemical genetic screen for cell cycle inhibitors in zebrafish embryos

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Identification of novel pigmentation modulators by chemical genetic screening

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Mutations affecting segment number and polarity in Drosophila

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

A genetic Xenopus laevis tadpole model to study lymphangiogenesis

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

VEGF receptor signalling - in control of vascular function

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Matrix metalloproteinases and the regulation of tissue remodelling

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Discovery and use of small molecules for probing biological processes in zebrafish.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Small molecule developmental screens reveal the logic and timing of vertebrate development

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Convergence of distinct pathways to heart patterning revealed by the small molecule concentramide and the mutation heart-and-soul

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

The zebrafish genome in context: ohnologs gone missing

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Vertebrate genome evolution and the zebrafish gene map

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Organization of the pronephric kidney revealed by large-scale gene expression mapping.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Tight transcriptional control of the ETS domain factors Erm and Pea3 by Fgf signaling during early zebrafish development.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Defining synphenotype groups in Xenopus tropicalis by use of antisense morpholino oligonucleotides

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Wnt signalling in stem cells and cancer

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

A toxicity and hazard assessment of fourteen pharmaceuticals to Xenopus laevis larvae

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Screening of an annotated compound library for drug activity in a resistant myeloma cell line

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Biological Mechanism Profiling Using an Annotated Compound Library

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Identification of a novel retinoid by small molecule screening with zebrafish embryos

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Target-oriented and diversity-oriented organic synthesis in drug discovery

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Invertebrate animal models of diseases as screening tools in drug discovery

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Zebrafish angiogenesis: a new model for drug screening

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Induction of reversible hemolytic anemia in living zebrafish using a novel small molecule

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Identification of a specific inhibitor of the dishevelled PDZ domain

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

From Zebrafish to human: modular medical models

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Zebrafish genetics and vertebrate heart formation.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

TILLING--a high-throughput harvest for functional genomics

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Small molecules that delay S phase suppress a zebrafish bmyb mutant

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Split--pool synthesis of 1,3-dioxanes leading to arrayed stock solutions of single compounds sufficient for multiple phenotypic and protein-binding assays

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Chemical genetics: ligand-based discovery of gene function

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Exploring biology with small organic molecules

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Molecular genetics of human pigmentation diversity

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Piebaldism: an update

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Xenopus as a model organism in developmental chemical genetic screens

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

A chemical genomic approach identifies matrix metalloproteinases as playing an essential and specific role in Xenopus melanophore migration.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Chemical genomics identifies compounds affecting Xenopus laevis pigment cell development.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Gridlock: a model for coarctation of the aorta?

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Comparative genomics: genome-wide analysis in metazoan eukaryotes

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

MMP9 potentiates pulmonary metastasis formation

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Wnt/frizzled signaling during vertebrate retinal development

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Evaluation of aflatoxin B1 embryotoxicity using the frog embryo teratogenesis assay-Xenopus and bio-activation with microsome activation systems

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Xenopus as a model system for vertebrate heart development

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Melanocytes in development, regeneration, and cancer

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Transparent adult zebrafish as a tool for in vivo transplantation analysis

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Efficient target-selected mutagenesis in zebrafish

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Modular synthesis and preliminary biological evaluation of stereochemically diverse 1,3-dioxanes.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

BMP type I receptor inhibition reduces heterotopic [corrected] ossification

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

Small-molecule synergist of the Wnt/beta-catenin signaling pathway

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

gridlock, an HLH gene required for assembly of the aorta in zebrafish

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021

In vivo drug discovery in the zebrafish

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21967

7 January 2021