(Q37564322)

21 August 2017

Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress (English)

1 reference

21 August 2017

0 references

5

Brigitte van Zundert

1 reference

21 August 2017

Fabiola Rojas

1

1 reference

21 August 2017

Nicole Cortes

series ordinal

2

1 reference

21 August 2017

Sebastian Abarzua

series ordinal

3

1 reference

21 August 2017

Agnieszka Dyrda

series ordinal

4

1 reference

21 August 2017

language of work or name

1 reference

7 February 2014

1 reference

Frontiers in Cellular Neuroscience

21 August 2017

1 reference

21 August 2017

8

1 reference

21 August 2017

24

1 reference

describes a project that uses

21 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3916762/fullTextXML

inferred from PubMed Central ID database lookup

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Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS

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Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis

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Mutant SOD1-expressing astrocytes release toxic factors that trigger motoneuron death by inducing hyperexcitability

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23 August 2017

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23 August 2017

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Persistent inward currents in spinal motoneurons: important for normal function but potentially harmful after spinal cord injury and in amyotrophic lateral sclerosis

23 August 2017

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A review of the neural mechanisms of action and clinical efficiency of riluzole in treating amyotrophic lateral sclerosis: what have we learned in the last decade?

23 August 2017

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TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration

23 August 2017

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Oxidative stress in ALS: key role in motor neuron injury and therapeutic target

23 August 2017

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Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

23 August 2017

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TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

23 August 2017

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Extracellular mutant SOD1 induces microglial-mediated motoneuron injury

23 August 2017

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An in vitro screening cascade to identify neuroprotective antioxidants in ALS

23 August 2017

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Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice.

23 August 2017

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Redox modifier genes and pathways in amyotrophic lateral sclerosis

23 August 2017

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Neonatal neuronal circuitry shows hyperexcitable disturbance in a mouse model of the adult-onset neurodegenerative disease amyotrophic lateral sclerosis

23 August 2017

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Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice.

23 August 2017

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Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants

23 August 2017

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Evidence for a superoxide permeability pathway in endosomal membranes

23 August 2017

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Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

23 August 2017

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SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model

23 August 2017

1 reference

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Redox modifier genes in amyotrophic lateral sclerosis in mice.

23 August 2017

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Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

23 August 2017

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Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model

23 August 2017

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Molecular biology of amyotrophic lateral sclerosis: insights from genetics

23 August 2017

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The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice

23 August 2017

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Onset and progression in inherited ALS determined by motor neurons and microglia

23 August 2017

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Therapeutic potential of resveratrol: the in vivo evidence

23 August 2017

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23 August 2017

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Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis

23 August 2017

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Fluorescence probes used for detection of reactive oxygen species

23 August 2017

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Alpha-tocopherol: roles in prevention and therapy of human disease

23 August 2017

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Ca2+, mitochondria and selective motoneuron vulnerability: implications for ALS.

23 August 2017

1 reference

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Vitamin E intake and risk of amyotrophic lateral sclerosis

23 August 2017

1 reference

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High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study

23 August 2017

1 reference

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Unraveling the mechanisms involved in motor neuron degeneration in ALS

23 August 2017

1 reference

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Mechanisms of sodium channel inactivation

23 August 2017

1 reference

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Superoxide dismutase and the death of motoneurons in ALS.

23 August 2017

1 reference

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From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS

23 August 2017

1 reference

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Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis

23 August 2017

1 reference

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Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

23 August 2017

1 reference

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Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis

23 August 2017

1 reference

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Spinal inhibitory circuits and their role in motor neuron degeneration

23 August 2017

1 reference

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Amyotrophic lateral sclerosis: new insights into underlying molecular mechanisms and opportunities for therapeutic intervention.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

MKK6 phosphorylation regulates production of superoxide by enhancing Rac GTPase activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Modulation and block of ion channels: a new biology of polyamines

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Alterations in the motor neuron-renshaw cell circuit in the Sod1(G93A) mouse model

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Early pathogenesis in the adult-onset neurodegenerative disease amyotrophic lateral sclerosis

25 June 2018

1 reference

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Trolox-sensitive reactive oxygen species regulate mitochondrial morphology, oxidative phosphorylation and cytosolic calcium handling in healthy cells.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Increased persistent sodium current determines cortical hyperexcitability in a genetic model of amyotrophic lateral sclerosis

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Oxidation of multiple methionine residues impairs rapid sodium channel inactivation

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

ALSoD: A user-friendly online bioinformatics tool for amyotrophic lateral sclerosis genetics

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Altered postnatal maturation of electrical properties in spinal motoneurons in a mouse model of amyotrophic lateral sclerosis.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Transient oxidative stress evokes early changes in the functional properties of neonatal rat hypoglossal motoneurons in vitro

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Differential roles of NMDA Receptor Subtypes NR2A and NR2B in dendritic branch development and requirement of RasGRF1.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Early excitability changes in lumbar motoneurons of transgenic SOD1G85R and SOD1G(93A-Low) mice

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Mexiletine and lidocaine suppress the excitability of dorsal horn neurons.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Bolus injection of acetylcholine terminates atrial fibrillation in rats.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Increased persistent Na(+) current and its effect on excitability in motoneurones cultured from mutant SOD1 mice.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Suppression of lipid hydroperoxide-induced oxidative damage to cellular DNA by esculetin

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Evaluation of the probes 2′,7′-dichlorofluorescin diacetate, luminol, and lucigenin as indicators of reactive species formation

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

A double-blind, placebo-controlled randomized clinical trial of alpha-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis. ALS riluzole-tocopherol Study Group

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Oxygen-sensing persistent sodium channels in rat hippocampus.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Protein kinase C-dependent modulation of Na+ currents increases the excitability of rat neocortical pyramidal neurones

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

Molecular determinants of state-dependent block of Na+ channels by local anesthetics

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916762

A fluorescence-based method for measuring total plasma antioxidant capability

1 September 2018

1 reference

12 December 2020

Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase

1 reference

12 December 2020

Persistent inward currents in rat ventral horn neurones

1 reference

12 December 2020

Alterations in the motor neuron-renshaw cell circuit in the Sod1(G93A) mouse model

1 reference

12 December 2020

Inhibitory effect of esculetin on oxidative damage induced by t -butyl hydroperoxide in rat liver

1 reference

12 December 2020

Comparative effects of melatonin, l-deprenyl, Trolox and ascorbate in the suppression of hydroxyl radical formation during dopamine autoxidation in vitro

1 reference

12 December 2020

Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation

1 reference

12 December 2020

Identifiers

DOI

10.3389/FNCEL.2014.00024

1 reference

21 August 2017

1 reference

21 August 2017

PubMed publication ID

24570655

1 reference