(Q37599686)

21 August 2017

The role of the complement system and the activation fragment C5a in the central nervous system (English)

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21 August 2017

Trent M Woodruff

1

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author name string

Rahasson R Ager

2

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21 August 2017

Andrea J Tenner

3

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21 August 2017

Peter G Noakes

4

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21 August 2017

Stephen M Taylor

5

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21 August 2017

11 September 2009

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21 August 2017

NeuroMolecular Medicine

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21 August 2017

12

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21 August 2017

2

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21 August 2017

179-192

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https://scigraph.springernature.com/pub.10.1007/s12017-009-8085-y

21 August 2017

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cites work

The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis

1 reference

12 December 2020

Identification of complement 5a-like receptor (C5L2) from astrocytes: characterization of anti-inflammatory properties

1 reference

12 December 2020

Antibody-independent activation of the complement system by mitochondria is mediated by cardiolipin

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12 December 2020

Expression of the anaphylatoxin C5a receptor in the oligodendrocyte lineage.

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12 December 2020

Identification of four novel human G protein-coupled receptors expressed in the brain

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12 December 2020

Identification and characterization of the complement C5a anaphylatoxin receptor on human astrocytes

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12 December 2020

Role of complement anaphylatoxin receptors (C3aR, C5aR) in the development of the rat cerebellum

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12 December 2020

Protective immune responses against West Nile virus are primed by distinct complement activation pathways

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12 December 2020

Expression of complement C4 and C9 genes by human astrocytes.

1 reference

12 December 2020

Immune surveillance of the human central nervous system (CNS): different migration pathways of immune cells through the blood-brain barrier and blood-cerebrospinal fluid barrier in healthy persons

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12 December 2020

Complement: a novel factor in basal and ischemia-induced neurogenesis

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12 December 2020

Protective effect of C5a receptor inhibition after murine reperfused stroke

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12 December 2020

Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo

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12 December 2020

Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons

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12 December 2020

Kinetics of anaphylatoxin C5a receptor expression during experimental allergic encephalomyelitis

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12 December 2020

Complement activation by neurofibrillary tangles in Alzheimer's disease.

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12 December 2020

Complement components of the innate immune system in health and disease in the CNS.

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12 December 2020

Localization and cell association of C1q in Alzheimer's disease brain

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12 December 2020

C5 deficiency and C5a or C5aR blockade protects against cerebral malaria

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12 December 2020

Molecular organization of C9 within the membrane attack complex of complement. Induction of circular C9 polymerization by the C5b-8 assembly

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12 December 2020

Innate immunity in viral encephalitis: role of C5

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12 December 2020

A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells

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12 December 2020

Complement component C1q inhibits beta-amyloid- and serum amyloid P-induced neurotoxicity via caspase- and calpain-independent mechanisms.

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12 December 2020

Expression of a functional C5a receptor in regenerating hepatocytes and its involvement in a proliferative signaling pathway in rat

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12 December 2020

Increased complement biosynthesis by microglia and complement activation on neurons in Huntington's disease

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12 December 2020

Expression of C5a receptor in mouse brain: role in signal transduction and neurodegeneration.

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12 December 2020

Complement C1-inhibitor expression in Alzheimer's disease.

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12 December 2020

Expression of the receptors for the C5a anaphylatoxin, interleukin-8 and FMLP by human astrocytes and microglia

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12 December 2020

Experimental diffuse axonal injury induces enhanced neuronal C5a receptor mRNA expression in rats.

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12 December 2020

Interleukin-1 and tumor necrosis factor-mediated regulation of C3 gene expression in human astroglioma cells

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12 December 2020

beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain.

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12 December 2020

Expression of the receptor for complement C5a (CD88) is up-regulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system.

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12 December 2020

Spontaneous classical pathway activation and deficiency of membrane regulators render human neurons susceptible to complement lysis

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12 December 2020

Synergistic neuroprotective effects of C3a and C5a receptor blockade following intracerebral hemorrhage

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12 December 2020

Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease

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12 December 2020

Complement activation in amyloid plaques in Alzheimer's dementia.

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12 December 2020

Cytokines associated with amyloid plaques in Alzheimer's disease brain stimulate human glial and neuronal cell cultures to secrete early complement proteins, but not C1-inhibitor.

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12 December 2020

Complement activation on human neuroblastoma cell lines in vitro: route of activation and expression of functional complement regulatory proteins.

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12 December 2020

Studies on the interactions between C-reactive protein and complement proteins.

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12 December 2020

Neuronal expression of a functional receptor for the C5a complement activation fragment

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12 December 2020

C5b-9 complement complex in autoimmune demyelination and multiple sclerosis: dual role in neuroinflammation and neuroprotection

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12 December 2020

Production and interferon-gamma-mediated regulation of complement component C2 and factors B and D by the astroglioma cell line U105-MG

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12 December 2020

Systemic complement depletion diminishes perihematomal brain edema in rats

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12 December 2020

Complement regulator loss on apoptotic neuronal cells causes increased complement activation and promotes both phagocytosis and cell lysis

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12 December 2020

The expression of complement regulatory proteins by adult human oligodendrocytes

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12 December 2020

Complement activation in experimental human malaria infection

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12 December 2020

Blocking the receptor for C5a in patients with rheumatoid arthritis does not reduce synovial inflammation

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12 December 2020

Antibody-independent killing of gram-negative bacteria via the classical pathway of complement

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12 December 2020

The Membrane Attack Complex of Complement Causes Severe Demyelination Associated with Acute Axonal Injury

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12 December 2020

Complement C5a receptor-mediated signaling may be involved in neurodegeneration in Alzheimer's disease

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12 December 2020

Oligodendrocyte cell death in pathogenesis of multiple sclerosis: Protection of oligodendrocytes from apoptosis by complement

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12 December 2020

Increased potency of a novel complement factor 5a receptor antagonist in a rat model of inflammatory bowel disease

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12 December 2020

The complement factor C5a receptor is upregulated in NFL-/- mouse motor neurons

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12 December 2020

Complement gene expression in neuroblastoma and astrocytoma cell lines of human origin

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12 December 2020

Neuronal localization of C1q in preclinical Alzheimer's disease

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12 December 2020

Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells

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12 December 2020

Human astrocytes express membrane cofactor protein (CD46), a regulator of complement activation

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12 December 2020

Complement and cytokine gene expression in cultured microglial derived from postmortem human brains

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12 December 2020

Expression of cytokines by human astrocytomas following stimulation by C3a and C5a anaphylatoxins: specific increase in interleukin-6 mRNA expression

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12 December 2020

Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide

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12 December 2020

Role of complement in motor neuron disease: animal models and therapeutic potential of complement inhibitors.

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12 December 2020

The complement-derived anaphylatoxin C5a increases microglial GLT-1 expression and glutamate uptake in a TNF-alpha-independent manner

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12 December 2020

Early plasma complement C3a levels correlate with functional outcome after aneurysmal subarachnoid hemorrhage

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12 December 2020

Complement-derived anaphylatoxin C5a protects against glutamate-mediated neurotoxicity.

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12 December 2020

Anaphylatoxin C5a receptor mRNA is strongly expressed in Kupffer and stellate cells and weakly in sinusoidal endothelial cells but not in hepatocytes of normal rat liver.

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12 December 2020

Complement C5a anaphylatoxin fragment causes apoptosis in TGW neuroblastoma cells

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12 December 2020

Blockade of the C5a receptor fails to protect against experimental autoimmune encephalomyelitis in rats

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12 December 2020

Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation

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12 December 2020

C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism

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12 December 2020

Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity.

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12 December 2020

Disruption of the C5a receptor gene fails to protect against experimental allergic encephalomyelitis.

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12 December 2020

Evidence for a functional role of the second C5a receptor C5L2.

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12 December 2020

Antibody-independent C1 activation by E. coli

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12 December 2020

The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)

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12 December 2020

Detection of mosaic protein mRNA in human astrocytes.

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12 December 2020

Ultrastructural localization of complement membrane attack complex (MAC)-like immunoreactivity in brains of patients with Alzheimer's disease.

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12 December 2020

Functional roles for C5a receptors in sepsis

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12 December 2020

Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions

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12 December 2020

Gene expression analysis of the murine model of amyotrophic lateral sclerosis: studies of the Leu126delTT mutation in SOD1.

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12 December 2020

Expression of C5a in the brain does not exacerbate experimental autoimmune encephalomyelitis.

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12 December 2020

Primary cultures of murine astrocytes produce C3 and factor B, two components of the alternative pathway of complement activation.

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12 December 2020

The receptor for complement anaphylatoxin C3a is expressed by myeloid cells and nonmyeloid cells in inflamed human central nervous system: analysis in multiple sclerosis and bacterial meningitis.

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12 December 2020

Complement: an inflammatory pathway fulfilling multiple roles at the interface of innate immunity and development.

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12 December 2020

Generation of C5a by phagocytic cells

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12 December 2020

The role of complement anaphylatoxin C5a in neurodegeneration: implications in Alzheimer's disease.

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12 December 2020

Activation of complement in the central nervous system: roles in neurodegeneration and neuroprotection

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12 December 2020

Generation of C5a in the absence of C3: a new complement activation pathway

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12 December 2020

Expression of a complete and functional complement system by human neuronal cells in vitro

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12 December 2020

C5a receptor expression by TGW neuroblastoma cells

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12 December 2020

Molecular cloning and characterization of the human anaphylatoxin C3a receptor

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12 December 2020

Expression of the complement classical pathway by human glioma in culture. A model for complement expression by nerve cells.

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12 December 2020

Decay-accelerating factor (CD55) is expressed by neurons in response to chronic but not acute autoimmune central nervous system inflammation associated with complement activation.

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12 December 2020

Detection of complement protein mRNA in human astrocytes by the polymerase chain reaction

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12 December 2020

Complement gene expression in human brain: comparison between normal and Alzheimer disease cases

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12 December 2020

Intracerebral complement C5a receptor (CD88) expression is regulated by TNF and lymphotoxin-alpha following closed head injury in mice

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12 December 2020

Complement-targeted therapeutics

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12 December 2020

Expression of decay-accelerating factor (CD55), membrane cofactor protein (CD46) and CD59 in the human astroglioma cell line, D54-MG, and primary rat astrocytes

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12 December 2020

Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines

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12 December 2020

Complement 5a controls motility of murine microglial cells in vitro via activation of an inhibitory G-protein and the rearrangement of the actin cytoskeleton

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12 December 2020

Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS.

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12 December 2020

Detection of the membrane inhibitor of reactive lysis (CD59) in diseased neurons of Alzheimer brain

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12 December 2020

C1q binding and C1 activation by various isolated cellular membranes.

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12 December 2020

Complement regulatory protein expression by a human oligodendrocyte cell line: cytokine regulation and comparison with astrocytes.

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12 December 2020

The classical complement cascade mediates CNS synapse elimination

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12 December 2020

Cell mediators of inflammation in the Alzheimer disease brain

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12 December 2020

Expression of complement components of the alternative pathway by glioma cell lines

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12 December 2020

Complement activation contributes to hypoxic-ischemic brain injury in neonatal rats.

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12 December 2020

Complement anaphylatoxin C5a neuroprotects through mitogen-activated protein kinase-dependent inhibition of caspase 3.

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12 December 2020

Expression of complement messenger RNAs and proteins by human oligodendroglial cells.

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12 December 2020

Induction of decay-accelerating factor by cytokines or the membrane-attack complex protects vascular endothelial cells against complement deposition

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12 December 2020

Molecular and cellular characterization of the membrane attack complex, C5b-9, in Alzheimer's disease

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12 December 2020

Characterization of C3a and C5a receptors in rat cerebellar granule neurons during maturation. Neuroprotective effect of C5a against apoptotic cell death

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12 December 2020

Interferon-gamma regulation of C3 gene expression in human astroglioma cells

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12 December 2020

Complement consumption in children with Plasmodium falciparum malaria

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12 December 2020

Plaque complement activation and cognitive loss in Alzheimer's disease

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12 December 2020

Identification and characterization of complement C3 receptors on human astrocytes

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12 December 2020

Chemotaxis by a CNS macrophage, the microglia

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12 December 2020

Microglial cell migration stimulated by ATP and C5a involve distinct molecular mechanisms: quantification of migration by a novel near-infrared method

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12 December 2020

An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2

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12 December 2020

Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease.

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12 December 2020

Complement C1 inhibitor is produced by brain tissue and is cleaved in Alzheimer disease

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12 December 2020

Type 1 astrocytes and oligodendrocyte-type 2 astrocyte glial progenitors migrate toward distinct molecules

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12 December 2020

Enhanced expression of chemotactic receptors in multiple sclerosis lesions.

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12 December 2020

Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity.

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12 December 2020

Bacterial meningitis: complement gene expression in the central nervous system

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12 December 2020

Expression of a functional anaphylatoxin C3a receptor by astrocytes.

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12 December 2020

Human oligodendrocytes are not sensitive to complement. A study of CD59 expression in the human central nervous system

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12 December 2020

Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on nonmyeloid cells of the liver and lung

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12 December 2020

Deletion of the complement anaphylatoxin C3a receptor attenuates, whereas ectopic expression of C3a in the brain exacerbates, experimental autoimmune encephalomyelitis

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12 December 2020

Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria

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12 December 2020

Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer's disease

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12 December 2020

Expression of Receptors for Complement Anaphylatoxins C3a and C5a Following Permanent Focal Cerebral Ischemia in the Mouse

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12 December 2020

Therapeutic activity of C5a receptor antagonists in a rat model of neurodegeneration

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12 December 2020

Control of the complement system.

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12 December 2020

Mechanisms of C5a and C3a complement fragment-induced [Ca2+]i signaling in mouse microglia

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12 December 2020

Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat.

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12 December 2020

The relative importance of local and systemic complement production in ischaemia, transplantation and other pathologies.

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12 December 2020

Complement C3 and C5 play critical roles in traumatic brain cryoinjury: blocking effects on neutrophil extravasation by C5a receptor antagonist.

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12 December 2020

TNF-alpha-mediated expression of the receptor for anaphylatoxin C5a on neurons in experimental Listeria meningoencephalitis

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12 December 2020

Alterations in plasma complement levels after human ischemic stroke.

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12 December 2020

The chemotactic receptor for human C5a anaphylatoxin

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12 December 2020

Liposome-induced activation of the classical complement pathway does not require immunoglobulin

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12 December 2020

10.1007/S12017-009-8085-Y

Identifiers

DOI

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21 August 2017

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