(Q37615354)

21 August 2017

1 reference

title

Regulation of endobiotics glucuronidation by ligand-activated transcription factors: physiological function and therapeutic potential (English)

1 reference

21 August 2017

Mélanie Verreault

1

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21 August 2017

Jenny Kaeding

2

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21 August 2017

Patrick Caron

3

1 reference

21 August 2017

Jocelyn Trottier

4

1 reference

21 August 2017

Laurent Grosse

5

1 reference

21 August 2017

Elise Houssin

6

1 reference

21 August 2017

Sophie Pâquet

7

1 reference

21 August 2017

Martin Perreault

8

1 reference

21 August 2017

Olivier Barbier

9

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21 August 2017

language of work or name

English

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publication date

1 February 2010

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21 August 2017

Drug Metabolism Reviews

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21 August 2017

42

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21 August 2017

1

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21 August 2017

110-122

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Heme oxygenase and the cardiovascular-renal system

21 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

AR, the cell cycle, and prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Androgen receptor mediates the expression of UDP-glucuronosyltransferase 2 B15 and B17 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Genomic and non-genomic interactions of PPARalpha with xenobiotic-metabolizing enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Lipid-activated transcription factors control bile acid glucuronidation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Non-carcinogenic effects of TCDD in animals.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Coordinate regulation of drug metabolism by xenobiotic nuclear receptors: UGTs acting together with CYPs and glucuronide transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Novel pathways of bile acid metabolism involving CYP3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

The role of chrysin and the ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Inherited disorders of bilirubin metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear fa

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Enzymatic production of bile Acid glucuronides used as analytical standards for liquid chromatography-mass spectrometry analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Bile acid regulation of gene expression: roles of nuclear hormone receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Isoform-specific regulation of uridine diphosphate-glucuronosyltransferase 2B enzymes in the human prostate: differential consequences for androgen and bioactive lipid inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Hormonal, cellular, and molecular regulation of normal and neoplastic prostatic development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Transcriptional programs activated by exposure of human prostate cancer cells to androgen

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Thyroxine-metabolizing rat uridine diphosphate-glucuronosyltransferase 1A7 is regulated by thyroid hormone receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

The PAS superfamily: sensors of environmental and developmental signals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

The aryl hydrocarbon receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Induction of bilirubin clearance by the constitutive androstane receptor (CAR)

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

The immunophilin-like protein XAP2 regulates ubiquitination and subcellular localization of the dioxin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

CAR and PXR: xenosensors of endocrine disrupters?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Investigation into the efficacy of bezafibrate against primary biliary cirrhosis, with histological references from cases receiving long term monotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Effect of fibroblastic growth factors (FGF) on steroid UDP-glucuronosyltransferase expression and activity in the LNCaP cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Lithocholic acid decreases expression of UGT2B7 in Caco-2 cells: a potential role for a negative farnesoid X receptor response element

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

The RXR heterodimers and orphan receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Bile acid N-acetylglucosaminidation. In vivo and in vitro evidence for a selective conjugation reaction of 7 beta-hydroxylated bile acids in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

The nuclear receptor superfamily and drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Nuclear receptor-mediated transcriptional regulation in Phase I, II, and III xenobiotic metabolizing systems

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

The program of androgen-responsive genes in neoplastic prostate epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Inverse Relationship Between Serum Bilirubin and Atherosclerosis in Men: A Meta-Analysis of Published Studies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Effect of bezafibrate in primary biliary cirrhosis: a pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Coordinated induction of drug transporters and phase I and II metabolism in human liver slices.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Targeting heme oxygenase: therapeutic implications for diseases of the cardiovascular system

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Activation of the Ah receptor signal transduction pathway by bilirubin and biliverdin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

21 January 2018

Bile acid biosynthesis

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Bilirubin concentration, UGT1A1*28 polymorphism, and coronary artery disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

"Let there be bile"--understanding hepatic injury in cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Novel identification of UDP-glucuronosyltransferase 1A10 as an estrogen-regulated target gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Bilirubin is an antioxidant of possible physiological importance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Nuclear receptor ligands in therapy of cholestatic liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

CAR and PXR: the xenobiotic-sensing receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Induction of human UGT1A1 by bilirubin through AhR dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Coordinate regulation of hepatic bile acid oxidation and conjugation by nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Isolation and characterization of the human UGT2B15 gene, localized within a cluster of UGT2B genes and pseudogenes on chromosome 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Role reversal: new insights from new ligands for the xenobiotic receptor CAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Future Treatment Options in PBC.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: insights into PXR-mediated gene regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Phase II enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Is bezafibrate histologically effective for primary biliary cirrhosis?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Xenobiotic nuclear receptor-mediated regulation of UDP-glucuronosyl-transferases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Total serum bilirubin and risk of cardiovascular disease in the Framingham offspring study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

Association of plasma bilirubin with coronary heart disease and segregation of bilirubin as a major gene trait: the NHLBI family heart study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

A genome scan for loci influencing anti-atherogenic serum bilirubin levels

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903219220

10.3109/03602530903219220

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference