(Q37619972)

21 August 2017

Hypoxia-inducible factor 1 contributes to N-acetylcysteine's protection in stroke (English)

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21 August 2017

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Ziyan Zhang

1

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21 August 2017

Jingqi Yan

2

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21 August 2017

Saeid Taheri

3

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21 August 2017

Ke Jian Liu

4

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21 August 2017

Honglian Shi

5

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21 August 2017

1 December 2013

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21 August 2017

14

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Free Radical Biology and Medicine

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published in

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21 August 2017

68

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21 August 2017

8-21

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describes a project that uses

21 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3943875/fullTextXML

inferred from PubMed Central ID database lookup

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Differential effects of HIF-1 inhibition by YC-1 on the overall outcome and blood-brain barrier damage in a rat model of ischemic stroke

23 August 2017

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N-acetylcysteine reduces lipopolysaccharide-sensitized hypoxic-ischemic brain injury

23 August 2017

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Antioxidant N-acetylcysteine inhibits the activation of JNK3 mediated by the GluR6-PSD95-MLK3 signaling module during cerebral ischemia in rat hippocampus

23 August 2017

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23 August 2017

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Molecular mechanisms of N-acetylcysteine actions

23 August 2017

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Heat-shock protein 90, a chaperone for folding and regulation

23 August 2017

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Beneficial effects of n-acetylcysteine on ischaemic brain injury

23 August 2017

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Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

23 August 2017

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Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

23 August 2017

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23 August 2017

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23 August 2017

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Differential changes of glutathione levels in astrocytes and neurons in ischemic brains by two-photon imaging.

23 August 2017

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A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1{alpha}.

14 September 2017

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RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha

14 September 2017

1 reference

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YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia

14 September 2017

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A domain responsible for HIF-1alpha degradation by YC-1, a novel anticancer agent.

14 September 2017

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17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

14 September 2017

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Amyloid beta peptide-induced cerebral endothelial cell death involves mitochondrial dysfunction and caspase activation

14 September 2017

1 reference

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Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.

28 September 2017

1 reference

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Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia

28 September 2017

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Correlation between motor impairment and infarct volume after permanent and transient middle cerebral artery occlusion in the rat.

28 September 2017

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N-acetylcysteine prevents loss of dopaminergic neurons in the EAAC1-/- mouse

28 September 2017

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Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

N-acetylcysteine slows down ageing and increases the life span of Drosophila melanogaster.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

Neuron-specific prolyl-4-hydroxylase domain 2 knockout reduces brain injury after transient cerebral ischemia

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

CX3CL1 is neuroprotective in permanent focal cerebral ischemia in rodents

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

HIF-1 alpha inhibition ameliorates neonatal brain damage after hypoxic-ischemic injury.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

Early inhibition of HIF-1alpha with small interfering RNA reduces ischemic-reperfused brain injury in rats.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

Effects of postresuscitation N-acetylcysteine on cerebral free radical production and perfusion during reoxygenation of hypoxic newborn piglets

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

Rapid morphologic plasticity of peri-infarct dendritic spines after focal ischemic stroke

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

Glucose up-regulates HIF-1 alpha expression in primary cortical neurons in response to hypoxia through maintaining cellular redox status

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

Inhibition of hypoxia-induced increase of blood-brain barrier permeability by YC-1 through the antagonism of HIF-1alpha accumulation and VEGF expression.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

Neuroprotective effects of N-acetylcysteine on experimental closed head trauma in rats

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

Bilateral molecular changes in a neonatal rat model of unilateral hypoxic-ischemic brain damage

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

Expression of the gene encoding the pro-apoptotic BNIP3 protein and stimulation of hypoxia-inducible factor-1alpha (HIF-1alpha) protein following focal cerebral ischemia in rats.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

N-acetylcysteine reduces lung reperfusion injury after deep hypothermia and total circulatory arrest

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

The antioxidant N-acetylcysteine preserves myocardial function and diminishes oxidative stress after cardioplegic arrest

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

N-Acetyl cysteine protects against injury in a rat model of focal cerebral ischemia

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

Protective effect of N-acetylcysteine on renal ischemia/reperfusion injury in the rat.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

Redox regulation of HIF-1alpha levels and HO-1 expression in renal medullary interstitial cells

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

Effects of normobaric hyperoxia in a rat model of focal cerebral ischemia-reperfusion

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

Hypoxic preconditioning induces changes in HIF-1 target genes in neonatal rat brain

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

Nuclear factor-kappa B activation during cerebral reperfusion: effect of attenuation with N-acetylcysteine treatment

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3943875

Activity in the peri-infarct rim in relation to recovery from stroke

1 September 2018

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12 December 2020

CaMKIIalpha-Cre transgene expression and recombination patterns in the mouse brain

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12 December 2020

Antioxidant/pro-oxidant equilibrium regulates HIF-1alpha and NF-kappa B redox sensitivity. Evidence for inhibition by glutathione oxidation in alveolar epithelial cells.

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12 December 2020

N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis

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12 December 2020

2-methoxyestradiol attenuates autophagy activation after global ischemia

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12 December 2020

Interstitial pO2 in ischemic penumbra and core are differentially affected following transient focal cerebral ischemia in rats

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12 December 2020

N -Acetylcysteine Enhances Hippocampal Neuronal Survival After Transient Forebrain Ischemia in Rats

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12 December 2020

N-acetyl cysteine ameliorates ischemic renal failure

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12 December 2020

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

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12 December 2020

10.1016/J.FREERADBIOMED.2013.11.007

Identifiers

DOI

1 reference

21 August 2017

1 reference

21 August 2017

PubMed publication ID

24296245

1 reference