(Q37638021)

English

NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers

scientific article published on January 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers (English)

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

David J. Bearss

14

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Maurizio Zangari

12

object named as

Maurizio Zangari

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Europe PubMed Central

21 August 2017

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author name string

Wen Zhou

1

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Europe PubMed Central

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21 August 2017

Ye Yang

2

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Europe PubMed Central

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21 August 2017

Jiliang Xia

3

1 reference

Europe PubMed Central

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21 August 2017

He Wang

4

1 reference

Europe PubMed Central

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21 August 2017

Mohamed E Salama

5

1 reference

Europe PubMed Central

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21 August 2017

Wei Xiong

6

1 reference

Europe PubMed Central

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21 August 2017

Hongwei Xu

7

1 reference

Europe PubMed Central

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21 August 2017

Shashirekha Shetty

8

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Europe PubMed Central

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21 August 2017

Tiehua Chen

9

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Europe PubMed Central

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21 August 2017

Zhaoyang Zeng

10

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Europe PubMed Central

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21 August 2017

Lei Shi

11

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Europe PubMed Central

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21 August 2017

Rodney Miles

13

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Europe PubMed Central

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21 August 2017

Guido Tricot

15

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Europe PubMed Central

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21 August 2017

Fenghuang Zhan

16

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Europe PubMed Central

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21 August 2017

publication date

1 January 2013

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Europe PubMed Central

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21 August 2017

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Europe PubMed Central

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21 August 2017

23

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Europe PubMed Central

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21 August 2017

1

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Europe PubMed Central

PMC publication ID

21 August 2017

48-62

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Europe PubMed Central

PMC publication ID

21 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3954609/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Proliferation is a central independent prognostic factor and target for personalized and risk-adapted treatment in multiple myeloma

1 reference

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23 August 2017

Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation

1 reference

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23 August 2017

Cancer statistics, 2009

1 reference

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Nip2/centrobin may be a substrate of Nek2 that is required for proper spindle assembly during mitosis in early mouse embryos

1 reference

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The consequences of tetraploidy and aneuploidy

1 reference

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Original CIN: reviewing roles for APC in chromosome instability

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Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK.

1 reference

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An analysis of the clinical and biologic significance of TP53 loss and the identification of potential novel transcriptional targets of TP53 in multiple myeloma

1 reference

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23 August 2017

beta-Catenin is a Nek2 substrate involved in centrosome separation

1 reference

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23 August 2017

The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells

1 reference

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23 August 2017

Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis

1 reference

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23 August 2017

The molecular classification of multiple myeloma

1 reference

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23 August 2017

ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal

1 reference

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On the road to cancer: aneuploidy and the mitotic checkpoint

1 reference

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23 August 2017

Nek2 kinase in chromosome instability and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3954609

23 August 2017

Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3954609

23 August 2017

Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles

1 reference

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Multistep Tumorigenesis of Multiple Myeloma: Its Molecular Delineation

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Mad2 and BubR1 function in a single checkpoint pathway that responds to a loss of tension.

1 reference

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23 August 2017

The subcellular destinations of APC proteins

1 reference

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Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling

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The protein kinase B/Akt signalling pathway in human malignancy

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Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

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Bcl-2 family proteins as targets for anticancer drug design

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23 August 2017

NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3954609

23 August 2017

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

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C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2

1 reference

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3954609

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Cell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc2 kinase

1 reference

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A mutation in Aspergillus nidulans that blocks the transition from interphase to prophase.

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Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils

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Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis

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A role for NIMA in the nuclear localization of cyclin B in Aspergillus nidulans

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A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1.

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A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers.

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Thalidomide and hematopoietic-cell transplantation for multiple myeloma

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Regulation of MDR1 expression and drug resistance by a positive feedback loop involving hyaluronan, phosphoinositide 3-kinase, and ErbB2.

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1 reference

https://pubmed.ncbi.nlm.nih.gov/23328480

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1 reference

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Mitotic mutants of Aspergillus nidulans

1 reference

https://pubmed.ncbi.nlm.nih.gov/23328480

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.CCR.2012.12.001

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

ResearchGate publication ID

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