(Q37766475)

22 August 2017

1 reference

title

Targeting mTOR in cancer: renal cell is just a beginning (English)

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22 August 2017

3

Bernard Escudier

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22 August 2017

Hamdy Azim

1

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PubMed ID

20563661

22 August 2017

Hatem A Azim

series ordinal

2

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22 August 2017

20 June 2010

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22 August 2017

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22 August 2017

5

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22 August 2017

4

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22 August 2017

269-280

1 reference

https://scigraph.springernature.com/pub.10.1007/s11523-010-0141-x

22 August 2017

0 references

cites work

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

1 reference

https://api.crossref.org/works/10.1007%2FS11523-010-0141-X

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-010-0141-X

Rhebbing up mTOR: New Insights on TSC1 and TSC2, and the Pathogenesis of Tuberous Sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-010-0141-X

Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-010-0141-X

Rapamycins: mechanism of action and cellular resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-010-0141-X

Regulation of oxygen homeostasis by hypoxia-inducible factor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-010-0141-X

Oncogenic PI3K and its role in cancer

21 January 2018

1 reference

12 December 2020

P-TEN exciting years: from the cytosol to the nucleus and back to keep cancer at bay

1 reference

12 December 2020

Current development of mTOR inhibitors as anticancer agents

1 reference

12 December 2020

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

1 reference

12 December 2020

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

1 reference

12 December 2020

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

1 reference

12 December 2020

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

1 reference

12 December 2020

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

1 reference

12 December 2020

PTEN and the PI3-kinase pathway in cancer

1 reference

12 December 2020

The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.

1 reference

12 December 2020

Potential histologic and molecular predictors of response to temsirolimus in patients with advanced renal cell carcinoma

1 reference

12 December 2020

Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels

1 reference

12 December 2020

Autophagy for cancer therapy through inhibition of pro-apoptotic proteins and mammalian target of rapamycin signaling.

1 reference

12 December 2020

Antiangiogenic potential of the Mammalian target of rapamycin inhibitor temsirolimus

1 reference

12 December 2020

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1 reference

12 December 2020

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

1 reference

12 December 2020

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

1 reference

12 December 2020

Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

1 reference

12 December 2020

Expression of cyclin D1, D3, E, and p27 in human renal cell carcinoma analysed by tissue microarray

1 reference

12 December 2020

Regulation of cell survival and proliferation by the FOXO (Forkhead box, class O) subfamily of Forkhead transcription factors

1 reference

12 December 2020

Von Hippel-Lindau tumor suppressor protein and hypoxia-inducible factor in kidney cancer

1 reference

12 December 2020

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

12 December 2020

Mammalian target of rapamycin inhibition as a therapeutic strategy in the management of urologic malignancies

1 reference

12 December 2020

Antineoplastic effect of rapamycin is potentiated by inhibition of IRS-1 signaling in prostate cancer cells xenografts.

1 reference

12 December 2020

A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer.

1 reference

12 December 2020

Hypoxia and angiogenesis: regulation of hypoxia-inducible factors via novel binding factors

1 reference

12 December 2020

Inhibition of the immune response by rapamycin, a new antifungal antibiotic

1 reference

12 December 2020

Targets and mechanisms for the regulation of translation in malignant transformation

1 reference

12 December 2020

The activation of phosphatidylinositol 3-kinase by Ras

1 reference

12 December 2020

The TOR pathway: a target for cancer therapy

1 reference

12 December 2020

Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1.

1 reference

12 December 2020

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

1 reference

12 December 2020

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

1 reference

12 December 2020

Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

1 reference

12 December 2020

The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors.

1 reference

12 December 2020

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

1 reference

12 December 2020

Autophagy as a cell death and tumor suppressor mechanism

1 reference

12 December 2020

The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cellular stability

1 reference

12 December 2020

The biology and clinical relevance of the PTEN tumor suppressor pathway

1 reference

12 December 2020

Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells

1 reference

12 December 2020

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

12 December 2020

Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma

1 reference

12 December 2020

Hypoxia-inducible factor 1 alpha in clear cell renal cell carcinoma

1 reference

12 December 2020

Reduced PTEN expression in gastric cancer and in the gastric mucosa of gastric cancer relatives

1 reference

12 December 2020

Dysregulated PTEN-PKB and negative receptor status in human breast cancer

1 reference

12 December 2020

PTEN mutations are common in sporadic microsatellite stable colorectal cancer

1 reference

12 December 2020

Effect of temsirolimus versus interferon-alpha on outcome of patients with advanced renal cell carcinoma of different tumor histologies

1 reference

12 December 2020

Phospholipase D confers rapamycin resistance in human breast cancer cells

1 reference

12 December 2020

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

1 reference

12 December 2020

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

1 reference

12 December 2020

Activation of mammalian target of rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma

1 reference

12 December 2020

High frequency of mutations of the PIK3CA gene in human cancers

1 reference

12 December 2020

Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance

1 reference

12 December 2020

TOR signaling in growth and metabolism

1 reference

12 December 2020

FAT: a novel domain in PIK-related kinases

1 reference

12 December 2020

Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial

1 reference

12 December 2020

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

1 reference

12 December 2020

Hypoxia-Inducible Factor 1α Expression in Renal Cell Carcinoma Analyzed by Tissue Microarray

1 reference

12 December 2020

Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo

1 reference

12 December 2020

Signaling control of mRNA translation in cancer pathogenesis

1 reference

12 December 2020

Analysis of PTEN and HIF-1alpha and correlation with efficacy in patients with advanced renal cell carcinoma treated with temsirolimus versus interferon-alpha

1 reference

12 December 2020

The expression of hypoxia-inducible factor 1alpha is a favorable independent prognostic factor in renal cell carcinoma

1 reference

12 December 2020

Rapamycin-sensitive pathway regulates mitochondrial membrane potential, autophagy, and survival in irradiated MCF-7 cells

1 reference

12 December 2020

Opposite translational control of GLUT1 and GLUT4 glucose transporter mRNAs in response to insulin. Role of mammalian target of rapamycin, protein kinase b, and phosphatidylinositol 3-kinase in GLUT1 mRNA translation

1 reference

12 December 2020

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 reference

12 December 2020

Ribosomal S6 kinase signaling and the control of translation

1 reference

12 December 2020

The protein kinase B/Akt signalling pathway in human malignancy

1 reference

12 December 2020

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

1 reference

12 December 2020

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

1 reference

12 December 2020

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

1 reference

12 December 2020

Autophagosomes: biogenesis from scratch?

1 reference

12 December 2020

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

1 reference

12 December 2020

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

1 reference

12 December 2020

Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function

1 reference

12 December 2020

The TOR kinases link nutrient sensing to cell growth

1 reference

12 December 2020

mTOR integrates amino acid- and energy-sensing pathways

1 reference

12 December 2020

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.

1 reference

12 December 2020

Targeting insulin-like growth factor type 1 receptor in cancer therapy.

1 reference

12 December 2020

Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism.

1 reference

12 December 2020

10.1007/S11523-010-0141-X

Identifiers

DOI

1 reference

release_qbdfvoh2sfat3czizedqevd66y

22 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/qbdfvoh2sfat3czizedqevd66y

24 November 2022

mapped directly with Wikidata item

PubMed ID

20563661

1 reference

PubMed ID

20563661