(Q37787547)

23 August 2017

title

Key role of the RhoA/Rho kinase system in pulmonary hypertension (English)

1 reference

23 August 2017

main subject

arterial hypertension

0 references

2

Philip I. Aaronson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20833255

11 July 2024

author name string

Michelle J. Connolly

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20833255

11 July 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20833255

11 July 2024

publication date

15 September 2010

1 reference

full work available at URL

23 August 2017

https://api.elsevier.com/content/article/PII:S109455391000101X?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

https://api.elsevier.com/content/article/PII:S109455391000101X?httpAccept=text/plain

11 July 2024

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Pulmonary Pharmacology & Therapeutics

11 July 2024

published in

1 reference

23 August 2017

volume

24

1 reference

23 August 2017

issue

1

1 reference

23 August 2017

page(s)

1-14

1 reference

Pulmonary arterial hypertension in France: results from a national registry

23 August 2017

cites work

1

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Updated clinical classification of pulmonary hypertension.

11 July 2024

2

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure.

11 July 2024

3

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Pulmonary diseases and the heart

11 July 2024

4

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Pulmonary hypertension in chronic obstructive pulmonary disease.

11 July 2024

5

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Pulmonary hypertension in COPD.

11 July 2024

6

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

The cancer paradigm of severe pulmonary arterial hypertension

11 July 2024

8

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

G protein-mediated inhibition of myosin light-chain phosphatase in vascular smooth muscle

11 July 2024

9

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Phosphorylation of the large subunit of myosin phosphatase and inhibition of phosphatase activity

11 July 2024

10

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

11 July 2024

11

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Efficacy and safety of fasudil in patients with stable angina: a double-blind, placebo-controlled, phase 2 trial

11 July 2024

12

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

The control of protein phosphatase-1 by targetting subunits. The major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase-1.

11 July 2024

13

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase

11 July 2024

14

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Plasma serotonin levels are normal in pulmonary arterial hypertension.

11 July 2024

15

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Ca2+-dependent activation of Rho and Rho kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contraction

11 July 2024

16

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Rho GTPases and the actin cytoskeleton

11 July 2024

17

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells.

11 July 2024

18

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes

11 July 2024

19

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

11 July 2024

20

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Arachidonic acid-induced Ca2+ sensitization of smooth muscle contraction through activation of Rho-kinase

11 July 2024

21

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Sphingosylphosphorylcholine is a novel messenger for Rho-kinase-mediated Ca2+ sensitization in the bovine cerebral artery: unimportant role for protein kinase C

11 July 2024

22

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells

11 July 2024

23

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

cGMP-dependent protein kinase phosphorylates and inactivates RhoA.

11 July 2024

26

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Intimal hyperplasia enhances myosin phosphorylation in rabbit carotid artery

11 July 2024

27

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

The Time Course of Myosin Light-Chain Phosphorylation in Blood-induced Vasospasm

11 July 2024

28

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Enhanced myosin light chain phosphorylations as a central mechanism for coronary artery spasm in a swine model with interleukin-1beta

11 July 2024

29

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm

11 July 2024

30

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Excitation-transcription coupling in arterial smooth muscle.

11 July 2024

31

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Smooth muscle differentiation marker gene expression is regulated by RhoA-mediated actin polymerization

11 July 2024

32

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling

11 July 2024

33

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

RAS and RHO GTPases in G1-phase cell-cycle regulation

11 July 2024

34

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Timing of cyclin D1 expression within G1 phase is controlled by Rho.

11 July 2024

35

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27

11 July 2024

36

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms

11 July 2024

37

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Inhibition of rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries

11 July 2024

38

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

A Drosophila homolog of LIM-kinase phosphorylates cofilin and induces actin cytoskeletal reorganization

11 July 2024

39

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Rho kinases in cardiovascular physiology and pathophysiology

11 July 2024

40

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Statins suppress MMP2 secretion via inactivation of RhoA/ROCK pathway in pulmonary vascular smooth muscles cells

11 July 2024

41

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Rho kinase in the regulation of cell death and survival

11 July 2024

42

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Rho-kinase inhibition reduces neointima formation after vascular injury by enhancing Bax expression and apoptosis.

11 July 2024

43

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

A meta-analysis of randomized controlled trials in pulmonary arterial hypertension

11 July 2024

45

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Endothelial and subintimal changes in rat hilar pulmonary artery during recovery from hypoxia. A quantitative ultrastructural study

11 July 2024

46

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Hypoxia-induced pulmonary artery adventitial remodeling and neovascularization: contribution of progenitor cells

11 July 2024

47

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: in vitro analysis.

11 July 2024

48

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

New findings in pulmonary arteries of rats with hypoxia-induced pulmonary hypertension

11 July 2024

50

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Rat pulmonary circulation after chronic hypoxia: hemodynamic and structural features

11 July 2024

51

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Adenovirus-mediated lung vascular endothelial growth factor overexpression protects against hypoxic pulmonary hypertension in rats

11 July 2024

52

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Long-term response to calcium channel blockers in idiopathic pulmonary arterial hypertension.

11 July 2024

53

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Oxygen therapy improves cardiac index and pulmonary vascular resistance in patients with pulmonary hypertension

11 July 2024

54

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension

11 July 2024

55

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Simvastatin causes endothelial cell apoptosis and attenuates severe pulmonary hypertension.

11 July 2024

56

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cells

11 July 2024

57

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Endothelial cells and pulmonary arterial hypertension: apoptosis, proliferation, interaction and transdifferentiation

11 July 2024

58

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension

11 July 2024

59

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Endothelial dysfunction in pulmonary hypertension

11 July 2024

60

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Impairment of endothelium-dependent pulmonary vasodilation in patients with primary pulmonary hypertension

11 July 2024

61

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension

11 July 2024

62

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension

11 July 2024

63

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

High expression of endothelial nitric oxide synthase in plexiform lesions of pulmonary hypertension

11 July 2024

64

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Coagulation and fibrinolytic profiles in patients with severe pulmonary hypertension

11 July 2024

65

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension

11 July 2024

66

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

The role of thrombosis in severe pulmonary hypertension

11 July 2024

67

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Pulmonary hypertension due to BMPR2 mutation: a new paradigm for tissue remodeling?

11 July 2024

68

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Transforming growth factor beta/bone morphogenic protein signaling in pulmonary arterial hypertension: remodeling revisited

11 July 2024

69

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Molecular mechanisms of pulmonary arterial hypertension: role of mutations in the bone morphogenetic protein type II receptor

11 July 2024

70

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Genetics and genomics of pulmonary arterial hypertension

11 July 2024

71

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension.

11 July 2024

72

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells

11 July 2024

73

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor

11 July 2024

74

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Bone morphogenetic protein signalling in heritable versus idiopathic pulmonary hypertension

11 July 2024

75

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins

11 July 2024

76

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways

11 July 2024

77

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

TGF-beta and BMPR-II pharmacology--implications for pulmonary vascular diseases

11 July 2024

78

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors

11 July 2024

79

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Role of endothelin receptor antagonists in the treatment of pulmonary arterial hypertension

11 July 2024

80

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Endothelin-1 in primary pulmonary hypertension and the Eisenmenger syndrome.

11 July 2024

81

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Expression of endothelin-1 in the lungs of patients with pulmonary hypertension.

11 July 2024

82

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Endothelin-1, via ETA receptor and independently of transforming growth factor-beta, increases the connective tissue growth factor in vascular smooth muscle cells.

11 July 2024

83

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

[Are the primary vascular forms of chronic pulmonary heart disease becoming more common?]

11 July 2024

84

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Appetite-suppressant drugs and the risk of primary pulmonary hypertension. International Primary Pulmonary Hypertension Study Group

11 July 2024

85

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice

11 July 2024

86

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Anorexic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction

11 July 2024

87

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Dexfenfluramine increases pulmonary artery smooth muscle intracellular Ca2+, independent of membrane potential

11 July 2024

88

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Increased plasma serotonin in primary pulmonary hypertension

11 July 2024

89

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia.

11 July 2024

90

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension

11 July 2024

91

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice

11 July 2024

92

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Dysfunctional Smad Signaling Contributes to Abnormal Smooth Muscle Cell Proliferation in Familial Pulmonary Arterial Hypertension

11 July 2024

93

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Inflammation, growth factors, and pulmonary vascular remodeling

11 July 2024

94

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension

11 July 2024

95

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Chemokine macrophage inflammatory protein-1alpha mRNA expression in lung biopsy specimens of primary pulmonary hypertension.

11 July 2024

96

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension.

11 July 2024

97

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Increased plasma P-selectin and decreased thrombomodulin in pulmonary arterial hypertension were improved by continuous prostacyclin therapy

11 July 2024

98

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Inflammation in pulmonary arterial hypertension.

11 July 2024

99

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle

11 July 2024

100

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension.

11 July 2024

101

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Long-term inhibition of Rho kinase with fasudil attenuates high flow induced pulmonary artery remodeling in rats

11 July 2024

102

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Role of Rho-associated kinase in neointima formation after vascular injury

11 July 2024

103

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury

11 July 2024

104

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells

11 July 2024

105

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells

11 July 2024

106

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

RhoGDI-1 modulation of the activity of monomeric RhoGTPase RhoA regulates endothelial barrier function in mouse lungs

11 July 2024

107

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

11 July 2024

108

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo

11 July 2024

109

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Activation of RhoA by thrombin in endothelial hyperpermeability: role of Rho kinase and protein tyrosine kinases

11 July 2024

110

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Inhibitory effects of ML-9, wortmannin, and Y-27632 on the chemotaxis of vascular smooth muscle cells in response to platelet-derived growth factor-BB.

11 July 2024

111

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways.

11 July 2024

112

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Serotonin induces Rho/ROCK-dependent activation of Smads 1/5/8 in pulmonary artery smooth muscle cells

11 July 2024

113

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta

11 July 2024

114

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells

11 July 2024

115

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin

11 July 2024

116

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release

11 July 2024

117

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Transglutaminase-dependent RhoA activation and depletion by serotonin in vascular smooth muscle cells.

11 July 2024

118

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

NFAT regulation in smooth muscle

11 July 2024

119

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted

11 July 2024

120

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Nuclear factor of activated T cells and serum response factor cooperatively regulate the activity of an alpha-actin intronic enhancer

11 July 2024

121

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

NFATc3 mediates chronic hypoxia-induced pulmonary arterial remodeling with alpha-actin up-regulation

11 July 2024

122

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Constrictor-induced translocation of NFAT3 in human and rat pulmonary artery smooth muscle

11 July 2024

123

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

NFATc3 contributes to intermittent hypoxia-induced arterial remodeling in mice

11 July 2024

124

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Urotensin II induces phenotypic differentiation, migration, and collagen synthesis of adventitial fibroblasts from rat aorta

11 July 2024

125

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension

11 July 2024

126

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Beneficial acute effects of rho-kinase inhibitor in patients with pulmonary arterial hypertension

11 July 2024

127

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Acute inhibition of Rho-kinase attenuates pulmonary hypertension in patients with congenital heart disease

11 July 2024

128

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Altered pulmonary vasoreactivity in the chronically hypoxic lung

11 July 2024

129

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia

11 July 2024

130

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

5-Hydroxytryptamine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats

11 July 2024

131

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Phosphodiesterase isoforms in the pulmonary arterial circulation of the rat: changes in pulmonary hypertension

11 July 2024

132

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Chronic hypoxia selectively augments endothelium-dependent pulmonary arterial vasodilation

11 July 2024

133

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung

11 July 2024

134

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Simvastatin and sildenafil combine to attenuate pulmonary hypertension

11 July 2024

135

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Variable expression of endothelial NO synthase in three forms of rat pulmonary hypertension

11 July 2024

136

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Impairment of endothelium-dependent pulmonary-artery relaxation in chronic obstructive lung disease

11 July 2024

137

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

The role of the renin-angiotensin and natriuretic peptide systems in the pulmonary vasculature

11 July 2024

138

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Circulating endothelin-1 concentrations in patients with chronic hypoxia

11 July 2024

139

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Serotonin receptor antagonist inhibits monocrotaline-induced pulmonary hypertension and prolongs survival in rats

11 July 2024

140

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats

11 July 2024

141

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Acute and chronic hypoxic pulmonary vasoconstriction: a central role for endothelin-1?

11 July 2024

142

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Enhanced endothelin-1 and endothelin receptor gene expression in chronic hypoxia

11 July 2024

143

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand

11 July 2024

144

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension

11 July 2024

146

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Inhibition of voltage-gated K(+) currents by endothelin-1 in human pulmonary arterial myocytes

11 July 2024

147

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats

11 July 2024

148

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Reactive oxygen species mediate RhoA/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia

11 July 2024

149

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Chronic hypoxia augments protein kinase G-mediated Ca2+ desensitization in pulmonary vascular smooth muscle through inhibition of RhoA/Rho kinase signaling

11 July 2024

150

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Effect of a serotonin receptor antagonist on interleukin-6-induced pulmonary hypertension in rats

11 July 2024

151

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Evidence for a control of plasma serotonin levels by 5-hydroxytryptamine(2B) receptors in mice

11 July 2024

152

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene.

11 July 2024

153

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension.

11 July 2024

154

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation

11 July 2024

155

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

L-type Ca(2+) channels, resting [Ca(2+)](i), and ET-1-induced responses in chronically hypoxic pulmonary myocytes

11 July 2024

156

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Chronic hypoxia-induced upregulation of store-operated and receptor-operated Ca2+ channels in pulmonary arterial smooth muscle cells: a novel mechanism of hypoxic pulmonary hypertension

11 July 2024

157

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Chronic hypoxia is associated with reduced delayed rectifier K+ current in rat pulmonary artery muscle cells

11 July 2024

158

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Influence of chronic hypoxia on the contributions of non-inactivating and delayed rectifier K currents to the resting potential and tone of rat pulmonary artery smooth muscle

11 July 2024

159

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Chronic hypoxia decreases K(V) channel expression and function in pulmonary artery myocytes

11 July 2024

160

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes

11 July 2024

161

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells

11 July 2024

162

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange

11 July 2024

164

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Clinical aspects of hypoxic pulmonary vasoconstriction

11 July 2024

165

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Inhibition of sustained hypoxic vasoconstriction by Y-27632 in isolated intrapulmonary arteries and perfused lung of the rat.

11 July 2024

166

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase.

11 July 2024

167

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Rho-kinase activation is involved in hypoxia-induced pulmonary vasoconstriction

11 July 2024

168

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Interaction between src family kinases and rho-kinase in agonist-induced Ca2+-sensitization of rat pulmonary artery.

11 July 2024

169

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Lungs from chronically hypoxic rats have decreased pressor response to acute hypoxia

11 July 2024

170

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Alterations in a redox oxygen sensing mechanism in chronic hypoxia

11 July 2024

171

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

A pathophysiological study of 10 cases of hypoxic cor pulmonale

11 July 2024

172

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms

11 July 2024

173

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation

11 July 2024

175

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation.

11 July 2024

176

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Hypoxic activation of adventitial fibroblasts: role in vascular remodeling

11 July 2024

177

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Hypoxia-induced proliferative response of vascular adventitial fibroblasts is dependent on g protein-mediated activation of mitogen-activated protein kinases

11 July 2024

178

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Changes in arteriole in acute and chronic hypoxic pulmonary hypertension and recovery in rat

11 July 2024

179

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage

11 July 2024

180

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Vascular remodeling and ET-1 expression in rat strains with different responses to chronic hypoxia

11 July 2024

181

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Contribution of the 5-HT(1B) receptor to hypoxia-induced pulmonary hypertension: converging evidence using 5-HT(1B)-receptor knockout mice and the 5-HT(1B/1D)-receptor antagonist GR127935.

11 July 2024

182

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Effect of Tryptophan Hydroxylase 1 Deficiency on the Development of Hypoxia-Induced Pulmonary Hypertension

11 July 2024

183

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts

11 July 2024

184

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension

11 July 2024

185

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat.

11 July 2024

186

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats

11 July 2024

187

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation and RhoA/Rho kinase activation

11 July 2024

188

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries

11 July 2024

189

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Chronic hypoxia augments depolarization-induced Ca2+ sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA.

11 July 2024

190

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Role of src-family kinases in hypoxic vasoconstriction of rat pulmonary artery.

11 July 2024

191

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Superoxide constricts rat pulmonary arteries via Rho-kinase-mediated Ca(2+) sensitization.

11 July 2024

192

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Hypoxic pulmonary hypertension: role of superoxide and NADPH oxidase (gp91phox).

11 July 2024

193

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Generation of oxidative stress contributes to the development of pulmonary hypertension induced by hypoxia

11 July 2024

194

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Attenuation of chronic hypoxic pulmonary hypertension by simvastatin

11 July 2024

195

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Effects of pravastatin on functional capacity in patients with chronic obstructive pulmonary disease and pulmonary hypertension

11 July 2024

196

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats

11 July 2024

197

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

THE TERMINAL PORTION OF THE PULMONARY ARTERIAL TREE IN PEOPLE NATIVE TO HIGH ALTITUDES

11 July 2024

198

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Operation Everest II: elevated high-altitude pulmonary resistance unresponsive to oxygen.

11 July 2024

199

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice

11 July 2024

200

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension.

11 July 2024

201

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Acute vasodilator effects of Rho-kinase inhibitors in neonatal rats with pulmonary hypertension unresponsive to nitric oxide

11 July 2024

202

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Inhaled nitric oxide therapy for persistent pulmonary hypertension of the newborn: when is it enough?

11 July 2024

203

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats

11 July 2024

204

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Rho-dependent kinase is involved in agonist-activated calcium entry in rat arteries

11 July 2024

206

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase

11 July 2024

207

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Regulation of differentiation of vascular smooth muscle cells

11 July 2024

208

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Rho-kinase mediates angiotensin II-induced monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells

11 July 2024

209

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

The protein kinase inhibitor fasudil protects against ischemic myocardial injury induced by endothelin-1 in the rabbit

11 July 2024

210

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Human urotensin II-induced contraction and arterial smooth muscle cell proliferation are mediated by RhoA and Rho-kinase

11 July 2024

211

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Angiotensin-converting enzyme inhibitor preserves p21 and endothelial nitric oxide synthase expression in monocrotaline-induced pulmonary arterial hypertension in rats

11 July 2024

212

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary hypertension: a placebo-controlled study

11 July 2024

213

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

The upregulation of endothelial nitric oxide synthase and urotensin-II is associated with pulmonary hypertension and vascular diseases in rats produced by aortocaval shunting

11 July 2024

214

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Simvastatin attenuates smooth muscle neointimal proliferation and pulmonary hypertension in rats.

11 July 2024

215

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

New drug targets for pulmonary hypertension: Rho GTPases in pulmonary vascular remodelling

11 July 2024

216

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Cyclin-dependent kinase inhibitor p27Kip1, but not p21WAF1/Cip1, is required for inhibition of hypoxia-induced pulmonary hypertension and remodeling by heparin in mice

11 July 2024

217

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Heparin is a promising agent for the treatment of endometriosis-associated fibrosis

11 July 2024

218

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

Rho signals to cell growth and apoptosis

11 July 2024

219

1 reference

https://api.crossref.org/works/10.1016/J.PUPT.2010.09.001

11 July 2024

Identifiers

1 reference

23 August 2017

1 reference