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BH3-only proteins and their effects on cancer.
scientific article published on January 2010
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Europe PubMed Central
PMC publication ID
3733261
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20919637%20AND%20SRC:MED&resulttype=core&format=json
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15 February 2020
title
BH3-only proteins and their effects on cancer
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3733261
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20919637%20AND%20SRC:MED&resulttype=core&format=json
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15 February 2020
author name string
Thanh-Trang Vo
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1
1 reference
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Europe PubMed Central
PMC publication ID
3733261
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20919637%20AND%20SRC:MED&resulttype=core&format=json
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15 February 2020
Anthony Letai
series ordinal
2
1 reference
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Europe PubMed Central
PMC publication ID
3733261
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20919637%20AND%20SRC:MED&resulttype=core&format=json
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15 February 2020
language of work or name
English
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publication date
1 January 2010
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Europe PubMed Central
PMC publication ID
3733261
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20919637%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 February 2020
published in
Advances in Experimental Medicine and Biology
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stated in
Europe PubMed Central
PMC publication ID
3733261
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20919637%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 February 2020
volume
687
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Europe PubMed Central
PMC publication ID
3733261
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15 February 2020
page(s)
49-63
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Europe PubMed Central
PMC publication ID
3733261
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20919637%20AND%20SRC:MED&resulttype=core&format=json
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15 February 2020
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Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis
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6 September 2017
Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis
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6 September 2017
Expression of Bcl-2 family member Bid in normal and malignant tissues
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The expanding role of mitochondria in apoptosis
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6 September 2017
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6 September 2017
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
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6 September 2017
PUMA, a novel proapoptotic gene, is induced by p53
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6 September 2017
BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
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6 September 2017
Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation
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6 September 2017
Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies
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6 September 2017
Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis
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Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.
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Phosphorylation of the pro-apoptotic protein BIK: mapping of phosphorylation sites and effect on apoptosis
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Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
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tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
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The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells
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6 September 2017
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
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6 September 2017
Protein phosphatase 1alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis
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6 September 2017
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
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6 September 2017
Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.
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6 September 2017
The Hallmarks of Cancer
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6 September 2017
Caspase-9 and APAF-1 form an active holoenzyme
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6 September 2017
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
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6 September 2017
An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
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6 September 2017
The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
6 September 2017
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
6 September 2017
Selective regulation of Bcl-XL by a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
6 September 2017
Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
6 September 2017
Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
6 September 2017
Bim: a novel member of the Bcl-2 family that promotes apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
6 September 2017
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
6 September 2017
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
6 September 2017
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
6 September 2017
harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
6 September 2017
Bcl-2 targets the protein kinase Raf-1 to mitochondria
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
6 September 2017
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
6 September 2017
BID: a novel BH3 domain-only death agonist
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
6 September 2017
Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
6 September 2017
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
6 September 2017
Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
6 September 2017
Bid exhibits S phase checkpoint activation and plays a pro-apoptotic role in response to etoposide-induced DNA damage in hepatocellular carcinoma cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
14 September 2017
Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
14 September 2017
Transcriptional activation of the proapoptotic bik gene by E2F proteins in cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
14 September 2017
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
14 September 2017
Bmf is a possible mediator in histone deacetylase inhibitors FK228 and CBHA-induced apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
14 September 2017
Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
14 September 2017
Apoptosis of non-small-cell lung cancer cell lines after paclitaxel treatment involves the BH3-only proapoptotic protein Bim.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
14 September 2017
Inhibition of glucocorticoid-induced apoptosis by targeting the major splice variants of BIM mRNA with small interfering RNA and short hairpin RNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
14 September 2017
Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
14 September 2017
Microarray analysis of epigenetic silencing of gene expression in the KAS-6/1 multiple myeloma cell line
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
14 September 2017
BRCC2, a novel BH3-like domain-containing protein, induces apoptosis in a caspase-dependent manner
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
14 September 2017
The pro-apoptotic protein Bim is a convergence point for cAMP/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
14 September 2017
Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
14 September 2017
Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
28 September 2017
Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
28 September 2017
Specific and rapid induction of the proapoptotic protein Hrk after growth factor withdrawal in hematopoietic progenitor cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
28 September 2017
Bax-independent inhibition of apoptosis by Bcl-XL.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
28 September 2017
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
23 June 2018
BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
23 June 2018
Malignant melanoma: modern black plague and genetic black box.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
23 June 2018
Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
23 June 2018
Evidence for a novel tumor suppressor gene on chromosome 15 associated with progression to a metastatic stage in breast cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
23 June 2018
Cleavage of Bid by executioner caspases mediates feed forward amplification of mitochondrial outer membrane permeabilization during genotoxic stress-induced apoptosis in Jurkat cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
1 September 2018
Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
1 September 2018
Proapoptotic BID is an ATM effector in the DNA-damage response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
1 September 2018
Nomenclature of dynein light chain-linked BH3-only protein Bim isoforms.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
1 September 2018
Inactivating mutation of the pro-apoptotic gene BID in gastric cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
1 September 2018
Mutational analysis of Noxa gene in human cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
1 September 2018
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
1 September 2018
MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
1 September 2018
Bim plays a crucial role in synergistic induction of apoptosis by the histone deacetylase inhibitor SBHA and TRAIL in melanoma cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733261
retrieved
3 December 2018
PUMA expression is significantly reduced in human cutaneous melanomas
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20919637
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20919637
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20919637
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20919637
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Membrane-insertion fragments of Bcl-xL, Bax, and Bid
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20919637
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20919637
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Characterization of the human Rad51 genomic locus and examination of tumors with 15q14-15 loss of heterozygosity (LOH)
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20919637
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1007/978-1-4419-6706-0_3
1 reference
stated in
Europe PubMed Central
PMC publication ID
3733261
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20919637%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 February 2020
PMC publication ID
3733261
1 reference
stated in
Europe PubMed Central
PMC publication ID
3733261
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20919637%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 February 2020
PubMed publication ID
20919637
1 reference
stated in
Europe PubMed Central
PMC publication ID
3733261
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20919637%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 February 2020
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