(Q37808482)

23 August 2017

title

Cardiac slices as a predictive tool for arrhythmogenic potential of drugs and chemicals (English)

1 reference

23 August 2017

Thomas Meyer

1

1 reference

23 August 2017

Katharina Stuerz

2

1 reference

23 August 2017

Elke Guenther

3

1 reference

23 August 2017

Mitsuhiro Edamura

4

1 reference

23 August 2017

Udo Kraushaar

5

1 reference

23 August 2017

language of work or name

English

0 references

publication date

11 November 2010

1 reference

Expert Opinion on Drug Metabolism & Toxicology

23 August 2017

published in

1 reference

23 August 2017

volume

6

1 reference

23 August 2017

issue

12

1 reference

23 August 2017

page(s)

1461-1475

1 reference

New preclinical guidelines on drug effects on ventricular repolarization: safety pharmacology comes of age.

23 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

The role of pharmacological profiling in safety assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Embryogenesis of the heart muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Atrial fibrillation: cure or treat?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Reducing QT liability and proarrhythmic risk in drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Assessing risk of a prolonged QT interval-a survey of emergency physicians

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

QT interval prolongation during spontaneous episodes of hypoglycaemia in type 1 diabetes: the impact of heart rate correction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Is gender a risk factor for adverse drug reactions? The example of drug-induced long QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Mechanisms of drug induced QT interval prolongation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Molecular and cellular mechanisms of cardiac arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

21 January 2018

HERG1 channelopathies

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Long QT syndrome: novel insights into the mechanisms of cardiac arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

HERG binding specificity and binding site structure: evidence from a fragment-based evolutionary computing SAR study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

[3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Validation of a [3H]astemizole binding assay in HEK293 cells expressing HERG K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Screening for potassium channel modulators by a high through-put 86-rubidium efflux assay in a 96-well microtiter plate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Flux assays in high throughput screening of ion channels in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Rb+ flux through hERG channels affects the potency of channel blocking drugs: correlation with data obtained using a high-throughput Rb+ efflux assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

A structural basis for drug-induced long QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Potassium channels involved in the transduction mechanism of dopamine D2 receptors in rat lactotrophs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Active ion transport pathways in the bovine retinal pigment epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Evaluating the utility of cardiomyocytes from human pluripotent stem cells for drug screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Selection of ventricular-like cardiomyocytes from ES cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: a molecular and electrophysiological approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

In vitro pharmacologic testing using human induced pluripotent stem cell-derived cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Local control of excitation-contraction coupling in human embryonic stem cell-derived cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Cardiomyocyte differentiation of human induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Automated electrophysiology in the preclinical evaluation of drugs for potential QT prolongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Characterization of potassium channel modulators with QPatch automated patch-clamp technology: system characteristics and performance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Potassium currents expressed from Drosophila and mouse eag cDNAs in Xenopus oocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Transient gene expression in suspension HEK-293 cells: application to large-scale protein production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Low-glutamine fed-batch cultures of 293-HEK serum-free suspension cells for adenovirus production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

A rapid technique for the isolation and purification of adult cardiac muscle cells having respiratory control and a tolerance to calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

In vitro and in vivo models for testing arrhythmogenesis in drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Cultured adult cardiac myocytes: future applications, culture methods, morphological and electrophysiological properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Optical imaging of arrhythmias in tissue culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Vital staining of cardiac myocytes during embryonic stem cell cardiogenesis in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Generation of cardiomyocytes from embryonic stem cells experimental studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Recent advances in cardiovascular regenerative medicine: the induced pluripotent stem cell era.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Functional cardiomyocytes derived from human induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Differentiation of human embryonic stem cells to cardiomyocytes for in vitro and in vivo applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

In vitro electrophysiological drug testing using human embryonic stem cell derived cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

hERG channel trafficking: novel targets in drug-induced long QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Potential role of the membrane in hERG channel functioning and drug-induced long QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

hERG gating microdomains defined by S6 mutagenesis and molecular modeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Cardiac metabolism and arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Relationship between QaT and RR intervals in rats, guinea pigs, rabbits, and primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

A method for QT correction based on beat-to-beat analysis of the QT/RR interval relationship in conscious telemetred beagle dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Fever accentuates transmural dispersion of repolarization and facilitates development of early afterdepolarizations and torsade de pointes under long-QT Conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

hERG (KCNH2 or Kv11.1) K+ channels: screening for cardiac arrhythmia risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Cellular basis of drug-induced torsades de pointes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Myocardial tissue slices: organotypic pseudo-2D models for cardiac research & development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Neonatal murine heart slices. A robust model to study ventricular isometric contractions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Hypercontractile properties of cardiac muscle fibers in a knock-in mouse model of cardiac myosin-binding protein-C

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

An in vitro beating heart model for long-term assessment of experimental therapeutics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Architecture of the left ventricle: insights for optimal surgical ventricular restoration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Transseptal dispersion of repolarization and its role in the development of Torsade de Pointes arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Organotypic heart slices for cell transplantation and physiological studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Stationary and drifting spiral waves of excitation in isolated cardiac muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Ventricular slices of adult mouse hearts--a new multicellular in vitro model for electrophysiological studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Tissue slices from adult mammalian hearts as a model for pharmacological drug testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Nonradioactive rubidium ion efflux assay and its applications in drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Nonclinical proarrhythmia models: predicting Torsades de Pointes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Practical application of guinea pig telemetry system for QT evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Functional characterization of cardiomyocytes derived from murine induced pluripotent stem cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Arrhythmogenic actions of the Ca2+ channel agonist FPL-64716 in Langendorff-perfused murine hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Myocardial slice: a physiological approach to beta-adrenergic ([3H] CGP-12177) receptor binding in hamster and guinea pig heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Models of torsades de pointes: effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Electrophysiological effects of encainide on isolated cardiac muscle and Purkinje fibers and on the Langendorff-perfused guinea-pig heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Generation and characterization of functional cardiomyocytes from rhesus monkey embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Optical mapping of Langendorff-perfused human hearts: establishing a model for the study of ventricular fibrillation in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

New cell models and assays in cardiac safety profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

Comparison of the T-tubule system in adult rat ventricular and atrial myocytes, and its role in excitation–contraction coupling and inotropic stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2010.526601

10.1517/17425255.2010.526601

21 January 2018

Identifiers

DOI

1 reference

23 August 2017

1 reference