(Q37818287)

23 August 2017

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title

Cyclin-dependent kinase inhibitor p27 as a prognostic biomarker and potential cancer therapeutic target (English)

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23 August 2017

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Dan D Hershko

1

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PubMed ID

21142858

23 August 2017

language of work or name

English

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publication date

1 December 2010

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23 August 2017

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23 August 2017

6

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23 August 2017

1837-1847

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23 August 2017

12

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Principles of CDK regulation

23 August 2017

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Inhibitors of mammalian G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Translational control of p27Kip1 accumulation during the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

The SCF ubiquitin ligase: an extended look

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

SCF and Cullin/Ring H2-based ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Skp2 is oncogenic and overexpressed in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

A cohort study of p27 localization in colon cancer, body mass index, and patient survival

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Cytoplasmic p27 expression is an independent prognostic factor in ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Determination of molecular marker expression can predict clinical outcome in colon carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Prognostic significance of p27(kip-1) expression in colorectal adenocarcinomas is associated with tumor stage

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Cytoplasmic expression of p27(kip1) is associated with a favourable prognosis in colorectal cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

p27Kip1 in stage III colon cancer: implications for outcome following adjuvant chemotherapy in cancer and leukemia group B protocol 89803.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

p27(Kip1) and cyclin E expression and breast cancer survival after treatment with adjuvant chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

High p27Kip1 Expression Predicts Superior Relapse-Free and Overall Survival for Premenopausal Women With Early-Stage Breast Cancer Receiving Adjuvant Treatment With Tamoxifen Plus Goserelin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Prognostic implication of cyclin E expression and its relationship with cyclin D1 and p27Kip1 expression on tissue microarrays of node negative breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

The prognostic implication of the basal-like (cyclin E high/p27 low/p53+/glomeruloid-microvascular-proliferation+) phenotype of BRCA1-related breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Germline BRCA1/2 mutations and p27(Kip1) protein levels independently predict outcome after breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Prognostic role of p27Kip1 and apoptosis in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

p27(Kip1) as a prognostic factor in breast cancer: a systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Significance of skp2 expression in primary breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

The expression of the ubiquitin ligase subunit Cks1 in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Prognostic impact of Skp2 and p27 in human breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

p27(kip1) functional regulation in human cancer: a potential target for therapeutic designs.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Predictive value of decreased p27Kip1 protein expression for the recurrence-free and long-term survival of prostate cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Expression of the cell cycle inhibitor p27KIP1 is a new prognostic marker associated with survival in epithelial ovarian tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Cyclin-dependent kinase inhibitors CIP1 (p21) and KIP1 (p27) in ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Down-regulation of Cdk inhibitor p27 in oral squamous cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Prognostic significance of the cell cycle inhibitor p27Kip1 in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Reduced expression of p27Kip1 protein is associated with poor clinical outcome of breast cancer patients treated with systemic chemotherapy and is linked to cell proliferation and differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Over-expression of Skp2 is associated with resistance to preoperative doxorubicin-based chemotherapy in primary breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Testing the importance of p27 degradation by the SCFskp2 pathway in murine models of lung and colon cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Subcellular Localization and Protein Levels of Cyclin-Dependent Kinase Inhibitor p27 Independently Predict for Survival in Epithelial Ovarian Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.10.144

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

21 January 2018

1 reference

30 December 2023

https://opencitations.net/index/api/v1/citations/10.1172/JCI15795

Identifiers

DOI

10.2217/FON.10.144

1 reference

23 August 2017

1 reference

PubMed ID

21142858