(Q37851151)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21388336%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

review article

1 reference

title

Therapeutic targeting of tumor-stroma interactions (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21388336%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21388336%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

author name string

Peter Barrett-Lee

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21388336%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Robert I Nicholson

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21388336%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

language of work or name

English

0 references

publication date

10 March 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21388336%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Therapeutic Targets

25 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21388336%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

volume

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21388336%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21388336%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

page(s)

609-621

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21388336%20AND%20SRC:MED&resulttype=core&format=json

Fibroblast differentiation in wound healing and fibrosis

25 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

The stroma reaction myofibroblast: a key player in the control of tumor cell behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Stromal myofibroblasts are drivers of invasive cancer growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Myofibroblasts and mechano-regulation of connective tissue remodelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Cancer exosomes trigger fibroblast to myofibroblast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

21 January 2018

Fibroblasts in cancer

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

The myofibroblast: one function, multiple origins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Stroma-epithelium crosstalk in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Endothelial-stromal interactions in angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Molecular characterization of the tumor microenvironment in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

High interstitial fluid pressure - an obstacle in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

3D collagen type I matrix inhibits the antimigratory effect of doxorubicin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Integrins: bidirectional, allosteric signaling machines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

beta1-integrin-mediated signaling essentially contributes to cell survival after radiation-induced genotoxic injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Culture of human breast cancer cell line (MDA-MB-231) on fibronectin-coated surface induces pro-matrix metalloproteinase-9 expression and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Matrix metalloproteinases and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

External validation suggests Integrin beta 3 as prognostic biomarker in serous ovarian adenocarcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

{beta}3-integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Breast cancer cells in three-dimensional culture display an enhanced radioresponse after coordinate targeting of integrin alpha5beta1 and fibronectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

ERBB2-mediated transcriptional up-regulation of the alpha5beta1 integrin fibronectin receptor promotes tumor cell survival under adverse conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Targeting focal adhesion kinase with dominant-negative FRNK or Hsp90 inhibitor 17-DMAG suppresses tumor growth and metastasis of SiHa cervical xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Survivin enhances motility of melanoma cells by supporting Akt activation and {alpha}5 integrin upregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

The PI3K/Akt pathway upregulates Id1 and integrin α4 to enhance recruitment of human ovarian cancer endothelial progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Significance of integrin αvβ5 and erbB3 in enhanced cell migration and liver metastasis of colon carcinomas stimulated by hepatocyte-derived heregulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Rapamycin inhibits lung metastasis of B16 melanoma cells through down-regulating alphav integrin expression and up-regulating apoptosis signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Oscillatory flow-induced proliferation of osteoblast-like cells is mediated by alphavbeta3 and beta1 integrins through synergistic interactions of focal adhesion kinase and Shc with phosphatidylinositol 3-kinase and the Akt/mTOR/p70S6K pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Focal adhesion kinase: targeting adhesion signaling pathways for therapeutic intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Integrin (alpha6beta4) signals through Src to increase expression of S100A4, a metastasis-promoting factor: implications for cancer cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Src family kinases in tumor progression and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Inhibition of Src with AZD0530 reveals the Src-Focal Adhesion kinase complex as a novel therapeutic target in papillary and anaplastic thyroid cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Src kinase promotes adhesion-independent activation of FAK and enhances cellular migration in tamoxifen-resistant breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Integrins as target: first phase III trial launches, but questions remain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

A randomized phase 2 study of etaracizumab, a monoclonal antibody against integrin alpha(v)beta(3), + or - dacarbazine in patients with stage IV metastatic melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Hypoxia, inflammation, and the tumor microenvironment in metastatic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

In aged mice, outgrowth of intraocular melanoma depends on proangiogenic M2-type macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Radical causes of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Distinct role of macrophages in different tumor microenvironments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Role of tumor-associated macrophages in tumor progression and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Targeting tumour-associated macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Macrophages define the invasive microenvironment in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Macrophage polarization in tumour progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Macrophages regulate the angiogenic switch in a mouse model of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: possible involvement of TNFalpha and IL-1alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

High-density gene expression analysis of tumor-associated macrophages from mouse mammary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Antitumor activity of liposomal prednisolone phosphate depends on the presence of functional tumor-associated macrophages in tumor tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Anti-inflammatory properties of the novel antitumor agent yondelis (trabectedin): inhibition of macrophage differentiation and cytokine production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

NF-kappaB: linking inflammation and immunity to cancer development and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

"Re-educating" tumor-associated macrophages by targeting NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug resistance of small cell lung cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Can the pharmaceutical industry reduce attrition rates?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Imatinib upregulates compensatory integrin signaling in a mouse model of gastrointestinal stromal tumor and is more effective when combined with dasatinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

3D cell cultures of human head and neck squamous cell carcinoma cells are radiosensitized by the focal adhesion kinase inhibitor TAE226.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

beta1 integrin targeting to enhance radiation therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Phase I trial of a monoclonal antibody specific for alphavbeta3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumor perfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Phase I and pharmacokinetic study of etaracizumab (Abegrin), a humanized monoclonal antibody against alphavbeta3 integrin receptor, in patients with advanced solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Volociximab, a chimeric monoclonal antibody that specifically binds alpha5beta1 integrin: a phase I, pharmacokinetic, and biological correlative study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Integrins and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561201

10.1517/14728222.2011.561201

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21388336%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference