(Q37851872)

24 August 2017

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title

Aging and cancer: can mTOR inhibitors kill two birds with one drug? (English)

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24 August 2017

2

Arlan Richardson

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24 August 2017

Zelton Dave Sharp

1

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24 August 2017

publication date

11 March 2011

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24 August 2017

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24 August 2017

volume

6

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24 August 2017

issue

1

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24 August 2017

page(s)

41-51

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Gerontology: Healthy old age.

24 August 2017

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Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice

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Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans

21 January 2018

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Dietary restriction retards onset but not progression of leukemia in male F344 rats

21 January 2018

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Caloric restriction delays disease onset and mortality in rhesus monkeys

21 January 2018

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Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research

21 January 2018

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Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial

21 January 2018

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Aging, adiposity, and calorie restriction

21 January 2018

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Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans

21 January 2018

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Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy

21 January 2018

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Effects of caloric restriction on rodent drug and carcinogen metabolizing enzymes: implications for mutagenesis and cancer

21 January 2018

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Long-lived ames dwarf mice are resistant to chemical stressors

21 January 2018

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Calorie restriction delays spontaneous tumorigenesis in p53-knockout transgenic mice

21 January 2018

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Tumours with PI3K activation are resistant to dietary restriction

21 January 2018

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Minimal effects of dietary restriction on neuroendocrine carcinogenesis in Rb+/- mice.

21 January 2018

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The TOR pathway comes of age

21 January 2018

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C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span

21 January 2018

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Genetics: influence of TOR kinase on lifespan in C. elegans

21 January 2018

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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

21 January 2018

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4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila

21 January 2018

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Lessons on longevity from budding yeast

21 January 2018

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eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans

21 January 2018

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Regulation of translation initiation in eukaryotes: mechanisms and biological targets

21 January 2018

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Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans

21 January 2018

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A systematic RNAi screen for longevity genes in C. elegans

21 January 2018

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

21 January 2018

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TOR controls translation initiation and early G1 progression in yeast

21 January 2018

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Extension of chronological life span in yeast by decreased TOR pathway signaling

21 January 2018

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Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster

21 January 2018

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Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

21 January 2018

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Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo.

21 January 2018

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Design of aging intervention studies: the NIA interventions testing program

21 January 2018

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Structure of the human mTOR complex I and its implications for rapamycin inhibition.

21 January 2018

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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

21 January 2018

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The anabolic actions of growth hormone and thyroxine on protein metabolism in Snell dwarf and normal mice

21 January 2018

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Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.

21 January 2018

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Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response

21 January 2018

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Can autophagy promote longevity?

21 January 2018

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21 January 2018

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A role for autophagy in the extension of lifespan by dietary restriction in C. elegans

21 January 2018

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Autophagy is required for dietary restriction-mediated life span extension in C. elegans

21 January 2018

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Effect of aging and anti-aging caloric restriction on the endocrine regulation of rat liver autophagy

21 January 2018

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

21 January 2018

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Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae

21 January 2018

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Translational regulation of GCN4 and the general amino acid control of yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

TOR modulates GCN4-dependent expression of genes turned on by nitrogen limitation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Autoregulation in the biosynthesis of ribosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

TOR, a central controller of cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Paradoxical suppression of cellular senescence by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Inflammatory networks during cellular senescence: causes and consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Extending healthy life span--from yeast to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Evolutionary medicine: from dwarf model systems to healthy centenarians?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Targeting the mTOR signaling network in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Inflammation, aging, and cancer vaccines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Preventing fatal diseases increases healthcare costs: cause elimination life table approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

The metabolic syndrome--a new worldwide definition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Sirtuins as potential targets for metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Regulation of elongation phase of mRNA translation in diabetic nephropathy: amelioration by rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

The effect of metformin on the incidence of type 2 diabetes mellitus and cardiovascular disease risk factors in overweight and obese subjects--the Carmos study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Autophagy for the avoidance of neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

The role of oxygen availability in embryonic development and stem cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Dysregulation of the TSC-mTOR pathway in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

mTOR, translational control and human disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Mechanisms of vascular aging: new perspectives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Autophagy in cardiovascular disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

mTOR--beyond transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Neovascular age-related macular degeneration: potential therapies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

mTOR regulates memory CD8 T-cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Mammalian target of rapamycin: a new molecular target for breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Targeting the mTOR pathway using deforolimus in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

The emerging safety profile of mTOR inhibitors, a novel class of anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

The pharmacology of mTOR inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Targeting mTOR: something old, something new.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-011-0168-7

Akt/PKB and p38 MAPK signaling, translational initiation and longevity in Snell dwarf mouse livers

21 January 2018

1 reference

12 December 2020

Replicative senescence of human fibroblast-like cells in culture

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12 December 2020

The molecular target of rapamycin (mTOR) as a therapeutic target against cancer

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12 December 2020

Energy restriction for breast cancer prevention

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12 December 2020

mTORC1 signaling: what we still don't know

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12 December 2020

Negative energy balance induced by voluntary wheel running inhibits polyp development in APCMin mice

1 reference

12 December 2020

Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence

1 reference

12 December 2020

Cellular growth in organs of dwarf mice during treatment with growth hormone, thyroxine and plasma fractions containing somatomedin activity

1 reference

12 December 2020

Calorie restriction induces a p53-independent delay of spontaneous carcinogenesis in p53-deficient and wild-type mice.

1 reference

12 December 2020

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

1 reference

12 December 2020

Anti-tumor action of dietary restriction is lesion-dependent in male Fischer 344 rats

1 reference

12 December 2020

Calorie restriction and aging: the ultimate "cleansing diet"

1 reference

12 December 2020

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

1 reference

12 December 2020

1 reference

12 December 2020

Study of ribosomal level in the liver of the normal and dwarf mouse

1 reference

12 December 2020

1 reference

12 December 2020

Deforolimus (AP23573) a novel mTOR inhibitor in clinical development

1 reference

12 December 2020

Normal assembly of 60 S ribosomal subunits is required for the signaling in response to a secretory defect in Saccharomyces cerevisiae

1 reference

12 December 2020

Calorie restriction and diet composition modulate spontaneous intestinal tumorigenesis in Apc(Min) mice through different mechanisms

1 reference

12 December 2020

Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity

1 reference

12 December 2020

Protein homeostasis and aging: The importance of exquisite quality control

1 reference

12 December 2020

Growth hormone effects on RNA and protein synthesis in liver

1 reference

12 December 2020

10.1007/S11523-011-0168-7

Identifiers

DOI

1 reference

24 August 2017

1 reference