(Q37859076)

24 August 2017

1 reference

title

Effects of rapamycin and TOR on aging and memory: implications for Alzheimer's disease (English)

1 reference

24 August 2017

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1 reference

Renato X Santos

1

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Sónia C. Correia

Sónia C Correia

2

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Susana Cardoso

Susana Cardoso

3

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Cristina Carvalho

Cristina Carvalho

4

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Paula I. Moreira

Paula I Moreira

6

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author name string

Maria S Santos

5

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24 August 2017

language of work or name

English

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publication date

3 May 2011

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Journal of Neurochemistry

24 August 2017

published in

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24 August 2017

volume

117

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24 August 2017

issue

6

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24 August 2017

page(s)

927-936

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Autophagy is required for extension of yeast chronological life span by rapamycin

24 August 2017

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Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression

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Pathological implications of cell cycle re-entry in Alzheimer disease

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Raptor-rictor axis in TGFbeta-induced protein synthesis.

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Rapamycin decelerates cellular senescence

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Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis

21 January 2018

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Regulation of longevity and stress resistance by Sch9 in yeast

21 January 2018

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The role of amyloid beta peptide 42 in Alzheimer's disease

21 January 2018

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Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony

21 January 2018

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Inflamm-aging. An evolutionary perspective on immunosenescence

21 January 2018

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mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

21 January 2018

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ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

21 January 2018

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

21 January 2018

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Loss of perforated synapses in the dentate gyrus: morphological substrate of memory deficit in aged rats

21 January 2018

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SIRT1 negatively regulates the mammalian target of rapamycin

21 January 2018

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Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis

21 January 2018

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Cellular and molecular basis of beta-amyloid precursor protein metabolism

21 January 2018

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An expanding role for mTOR in cancer

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

The pharmacology of mTOR inhibition

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

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Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

21 January 2018

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A role for autophagy in the extension of lifespan by dietary restriction in C. elegans

21 January 2018

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The Free Radical Theory of Aging

21 January 2018

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mTOR signaling: at the crossroads of plasticity, memory and disease

21 January 2018

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Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron

21 January 2018

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Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 January 2018

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The growing role of mTOR in neuronal development and plasticity.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

The immunosuppressant rapamycin exacerbates neurotoxicity of Abeta peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Dietary deprivation extends lifespan in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Sir2 represses endogenous polymerase II transcription units in the ribosomal DNA nontranscribed spacer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Can autophagy promote longevity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Demography of dietary restriction and death in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

The progression of the pathological changes of Alzheimer's disease in frontal and temporal neocortex examined both at biopsy and at autopsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Rheb fills a GAP between TSC and TOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

The expanding TOR signaling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Quantitative immunohistochemistry of synaptophysin in human neocortex: an alternative method to estimate density of presynaptic terminals in paraffin sections

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Subfield history: caloric restriction, slowing aging, and extending life

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Brain and brawn: parallels in oxidative strength

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Alzheimer's disease: a lesson from mitochondrial dysfunction.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Autophagocytosis of mitochondria is prominent in Alzheimer disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

21 January 2018

1 reference

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Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Oxidative damage is the earliest event in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway

21 January 2018

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Extension of chronological life span in yeast by decreased TOR pathway signaling

21 January 2018

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Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling

21 January 2018

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21 January 2018

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Direct control of mitochondrial function by mTOR.

21 January 2018

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The target of rapamycin (TOR) proteins

21 January 2018

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Calorie restriction in primates: will it work and how will we know?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

A link between protein translation and body weight

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Tau suppression in a neurodegenerative mouse model improves memory function

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Targeting autophagy in the brain: a promising approach?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Growing roles for the mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity

21 January 2018

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Sirolimus: its discovery, biological properties, and mechanism of action

21 January 2018

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

21 January 2018

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21 January 2018

Coronary-artery stents

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To be or not to be toxic: aggregations in Huntington and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Regulation of translation initiation in eukaryotes: mechanisms and biological targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Targeting mammalian target of rapamycin (mTOR) for health and diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Sch9 is a major target of TORC1 in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Autophagy genes and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Genetics: influence of TOR kinase on lifespan in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Generation of superoxide-radical by the NADH:ubiquinone oxidoreductase of heart mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

mTORC1 signaling: what we still don't know

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Systematic gene expression profile of hypothalamus in calorie-restricted mice implicates the involvement of mTOR signaling in neuroprotective activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

TOR signaling in growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Structure of the human mTOR complex I and its implications for rapamycin inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Rapamycin promotes beta-amyloid production via ADAM-10 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Activation of mTORC2 by association with the ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

The intracellular domain of amyloid precursor protein interacts with FKBP12

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

The Rapamycin and FKBP12 Target (RAFT) Displays Phosphatidylinositol 4-Kinase Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07262.X

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.28.727

Identifiers

DOI

10.1111/J.1471-4159.2011.07262.X

1 reference

24 August 2017

1 reference