(Q37863144)

24 August 2017

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title

Silencing of CDK5 as potential therapy for Alzheimer's disease (English)

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Gloria Patricia Cardona-Gomez

24 August 2017

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6

object named as

Gloria Patricia Cardona-Gómez

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24 August 2017

author name string

Alejandro López-Tobón

1

1 reference

24 August 2017

John Fredy Castro-Álvarez

2

1 reference

24 August 2017

Diego Piedrahita

3

1 reference

24 August 2017

Ryan L Boudreau

4

1 reference

24 August 2017

Juan Carlos Gallego-Gómez

5

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24 August 2017

publication date

1 January 2011

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Reviews in the Neurosciences

24 August 2017

published in

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24 August 2017

volume

22

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24 August 2017

issue

2

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24 August 2017

page(s)

143-152

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Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease

24 August 2017

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21 January 2018

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Roscovitine reduces neuronal loss, glial activation, and neurologic deficits after brain trauma

21 January 2018

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GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/Cdk5 and p25/Cdk5.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

21 January 2018

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Modulation of the JNK and p38 pathways by cdk5 protein kinase in a transgenic mouse model of Alzheimer's disease

21 January 2018

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

21 January 2018

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No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro

21 January 2018

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Gene therapy: promises and problems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Association of neurofilament proteins with neuronal Cdk5 activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Gastric and pancreatic lesions in rats treated with a pan-CDK inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Viral-based modelling and correction of neurodegenerative diseases by RNA interference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

In vivo PET imaging and postmortem studies suggest potentially reversible and irreversible stages of brain metabolic failure in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

A hippocampal Cdk5 pathway regulates extinction of contextual fear

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Tau suppression in a neurodegenerative mouse model improves memory function

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Efficient characterization of retro-, lenti-, and foamyvector-transduced cell populations by high-accuracy insertion site sequencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Asymmetry in the assembly of the RNAi enzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Regional expression of key cell cycle proteins in brain from subjects with amnestic mild cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Coexpression of human cdk5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Gene therapy: twenty-first century medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Lentivirus-mediated gene transfer to the central nervous system: therapeutic and research applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick Type C mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

21 January 2018

Identifiers

DOI

10.1515/RNS.2011.015

1 reference

24 August 2017

1 reference