(Q37882401)

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An update on ABCB1 pharmacogenetics: insights from a 3D model into the location and evolutionary conservation of residues corresponding to SNPs associated with drug pharmacokinetics.

scientific article published on 31 May 2011

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scholarly article

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2 February 2020

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An update on ABCB1 pharmacogenetics: insights from a 3D model into the location and evolutionary conservation of residues corresponding to SNPs associated with drug pharmacokinetics (English)

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2 February 2020

pharmacokinetics

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based on heuristic

inferred from title

6

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2 February 2020

author name string

S J Wolf

1

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M Bachtiar

2

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J Wang

3

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T S Sim

4

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S S Chong

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publication date

31 May 2011

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The Pharmacogenomics Journal

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11

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315-325

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https://scigraph.springernature.com/pub.10.1038/tpj.2011.16

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Membrane topology of human ABC proteins.

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The A-loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding

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21 January 2018

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The conserved tyrosine residues 401 and 1044 in ATP sites of human P-glycoprotein are critical for ATP binding and hydrolysis: evidence for a conserved subdomain, the A-loop in the ATP-binding cassette.

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21 January 2018

ABC multidrug transporters: structure, function and role in chemoresistance.

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21 January 2018

About a switch: how P-glycoprotein (ABCB1) harnesses the energy of ATP binding and hydrolysis to do mechanical work

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21 January 2018

Biochemistry. Through a mirror, differently.

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21 January 2018

Clustal W and Clustal X version 2.0

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21 January 2018

Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance

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21 January 2018

Identification of functionally variant MDR1 alleles among European Americans and African Americans

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21 January 2018

Genomic evidence for recent positive selection at the human MDR1 gene locus

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21 January 2018

Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan

1 reference

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21 January 2018

Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense

1 reference

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21 January 2018

Synergy between conserved ABC signature Ser residues in P-glycoprotein catalysis

1 reference

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21 January 2018

A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function.

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21 January 2018

Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima

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21 January 2018

A "silent" polymorphism in the MDR1 gene changes substrate specificity

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21 January 2018

A simple method for displaying the hydropathic character of a protein

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21 January 2018

Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance

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21 January 2018

Improved energy coupling of human P-glycoprotein by the glycine 185 to valine mutation

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Interaction of transported drugs with the lipid bilayer and P-glycoprotein through a solvation exchange mechanism

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Functional characterization of coding polymorphisms in the human MDR1 gene using a vaccinia virus expression system.

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Quantitative structure--activity relationship analysis and molecular dynamics simulation to functionally validate nonsynonymous polymorphisms of human ABC transporter ABCB1 (P-glycoprotein/MDR1).

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MDR1 G1199A polymorphism alters permeability of HIV protease inhibitors across P-glycoprotein-expressing epithelial cells

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