(Q37894691)

24 August 2017

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title

Tuberculosis drugs: new candidates and how to find more (English)

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24 August 2017

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Claudia Sala

1

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Ruben Hartkoorn

object named as

Ruben C Hartkoorn

series ordinal

2

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publication date

1 June 2011

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24 August 2017

17

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based on heuristic

inferred from page(s)

published in

Future Microbiology

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24 August 2017

6

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24 August 2017

6

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24 August 2017

617-633

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Tuberculosis - metabolism and respiration in the absence of growth

24 August 2017

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The immunological aspects of latency in tuberculosis

21 January 2018

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M. tuberculosis persistence, latency, and drug tolerance

21 January 2018

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Tuberculosis and diabetes mellitus: convergence of two epidemics

21 January 2018

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Diabetes and the risk of tuberculosis: a neglected threat to public health?

21 January 2018

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Diabetes and tuberculosis: the impact of the diabetes epidemic on tuberculosis incidence

21 January 2018

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Development of new anti-tuberculosis drug candidates

21 January 2018

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A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis

21 January 2018

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Diarylquinolines target subunit c of mycobacterial ATP synthase

21 January 2018

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Rates and mechanisms of resistance development in Mycobacterium tuberculosis to a novel diarylquinoline ATP synthase inhibitor

21 January 2018

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Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis

21 January 2018

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The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis

21 January 2018

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Simple model for testing drugs against nonreplicating Mycobacterium tuberculosis

21 January 2018

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Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910.

21 January 2018

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Activities of TMC207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs

21 January 2018

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The diarylquinoline R207910 is bactericidal against Mycobacterium leprae in mice at low dose and administered intermittently

21 January 2018

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The diarylquinoline TMC207 for multidrug-resistant tuberculosis

21 January 2018

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Early bactericidal activity and pharmacokinetics of the diarylquinoline TMC207 in treatment of pulmonary tuberculosis

21 January 2018

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A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis

21 January 2018

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Mycobacterium leprae is naturally resistant to PA-824

21 January 2018

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Prospects for clinical introduction of nitroimidazole antibiotics for the treatment of tuberculosis

21 January 2018

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Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis

21 January 2018

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The mechanism of action of PA-824: Novel insights from transcriptional profiling

21 January 2018

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PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release

21 January 2018

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Early bactericidal activity and pharmacokinetics of PA-824 in smear-positive tuberculosis patients

21 January 2018

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Safety, tolerability, and pharmacokinetics of PA-824 in healthy subjects

21 January 2018

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OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice

21 January 2018

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Case series report of a linezolid-containing regimen for extensively drug-resistant tuberculosis

21 January 2018

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Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity

21 January 2018

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Promising antituberculosis activity of the oxazolidinone PNU-100480 relative to that of linezolid in a murine model

21 January 2018

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Mechanism of action of the oxazolidinone antibacterial agents

21 January 2018

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Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit

21 January 2018

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Pharmacokinetics and whole-blood bactericidal activity against Mycobacterium tuberculosis of single doses of PNU-100480 in healthy volunteers.

21 January 2018

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Drugs in development for tuberculosis

21 January 2018

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New antituberculous drugs in development

21 January 2018

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Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediamines

21 January 2018

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Drug therapy of experimental tuberculosis (TB): improved outcome by combining SQ109, a new diamine antibiotic, with existing TB drugs

21 January 2018

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Pharmacodynamics and pharmacokinetics of SQ109, a new diamine-based antitubercular drug

21 January 2018

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Synthesis of novel [1,2]-diamines with antituberculosis activity

21 January 2018

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Synthesis and evaluation of SQ109 analogues as potential anti-tuberculosis candidates

21 January 2018

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Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis

21 January 2018

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Clinical isolates of Mycobacterium tuberculosis in four European hospitals are uniformly susceptible to benzothiazinones

21 January 2018

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High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors

21 January 2018

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Leads for antitubercular compounds from kinase inhibitor library screens

21 January 2018

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Benzothiazinones: prodrugs that covalently modify the decaprenylphosphoryl-β-D-ribose 2'-epimerase DprE1 of Mycobacterium tuberculosis

21 January 2018

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Serine beta-lactamases and penicillin-binding proteins

21 January 2018

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Distribution and characterization of beta-lactamases of mycobacteria and related organisms.

21 January 2018

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Can penicillins and other beta-lactam antibiotics be used to treat tuberculosis?

21 January 2018

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The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin.

21 January 2018

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The peptidoglycan of stationary-phase Mycobacterium tuberculosis predominantly contains cross-links generated by L,D-transpeptidation

21 January 2018

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Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis

21 January 2018

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

21 January 2018

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Tetrazolium microplate assay as a rapid and inexpensive colorimetric method for determination of antibiotic susceptibility of Mycobacterium tuberculosis

21 January 2018

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Improved green fluorescent protein reporter gene-based microplate screening for antituberculosis compounds by utilizing an acetamidase promoter.

21 January 2018

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Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis

21 January 2018

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High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv

21 January 2018

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Antituberculosis activity of the molecular libraries screening center network library

21 January 2018

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New anti-tuberculosis agents amongst known drugs

21 January 2018

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Dormancy of Mycobacterium tuberculosis and latency of disease

21 January 2018

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Nonreplicating persistence of mycobacterium tuberculosis

21 January 2018

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Metronidazole is bactericidal to dormant cells of Mycobacterium tuberculosis

21 January 2018

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Detection of mRNA transcripts and active transcription in persistent Mycobacterium tuberculosis induced by exposure to rifampin or pyrazinamide

21 January 2018

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A novel in vitro multiple-stress dormancy model for Mycobacterium tuberculosis generates a lipid-loaded, drug-tolerant, dormant pathogen

21 January 2018

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In vitro model of mycobacterial growth arrest using nitric oxide with limited air.

21 January 2018

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Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling

21 January 2018

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Differential drug susceptibility of intracellular and extracellular tuberculosis, and the impact of P-glycoprotein

21 January 2018

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A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

21 January 2018

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inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis

21 January 2018

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Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.

21 January 2018

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The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol

21 January 2018

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The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action

21 January 2018

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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

21 January 2018

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Tetracycline-inducible gene regulation in mycobacteria

21 January 2018

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Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor

21 January 2018

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Gene regulation by tetracyclines. Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes

21 January 2018

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Anhydrotetracycline, a novel effector for tetracycline controlled gene expression systems in eukaryotic cells

21 January 2018

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Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection

21 January 2018

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Silencing Mycobacterium smegmatis by using tetracycline repressors

21 January 2018

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In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice

21 January 2018

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Pristinamycin-inducible gene regulation in mycobacteria.

21 January 2018

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Unusual regulatory mechanism for a Streptomyces multidrug resistance gene, ptr, involving three homologous protein-binding sites overlapping the promoter region.

21 January 2018

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Development of a repressible mycobacterial promoter system based on two transcriptional repressors

21 January 2018

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Protein inactivation in mycobacteria by controlled proteolysis and its application to deplete the beta subunit of RNA polymerase.

21 January 2018

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Biology of trans-translation

21 January 2018

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A specificity-enhancing factor for the ClpXP degradation machine

21 January 2018

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Interaction of rifamycin with bacterial RNA polymerase

21 January 2018

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Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence

21 January 2018

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CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence

21 January 2018

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Inhibitors selective for mycobacterial versus human proteasomes

21 January 2018

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Genes required for mycobacterial growth defined by high density mutagenesis

21 January 2018

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Genetic requirements for mycobacterial survival during infection

21 January 2018

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Massive gene decay in the leprosy bacillus

21 January 2018

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Structural genomics approach to drug discovery for Mycobacterium tuberculosis

21 January 2018

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Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides

21 January 2018

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Signalling inhibitors against Mycobacterium tuberculosis--early days of a new therapeutic concept in tuberculosis.

21 January 2018

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A novel drug discovery concept for tuberculosis: inhibition of bacterial and host cell signalling.

21 January 2018

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Fragment-based approaches to enzyme inhibition

21 January 2018

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Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase

21 January 2018

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Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.

21 January 2018

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Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB.

21 January 2018

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In silico structure-based design of a novel class of potent and selective small peptide inhibitor of Mycobacterium tuberculosis Dihydrofolate reductase, a potential target for anti-TB drug discovery

21 January 2018

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Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis

21 January 2018

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Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data

21 January 2018

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Structure-based design of DevR inhibitor active against nonreplicating Mycobacterium tuberculosis

21 January 2018

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Antibacterial drug discovery and structure-based design

21 January 2018

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Structural bioinformatic approaches to the discovery of new antimycobacterial drugs

21 January 2018

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A synthetic mammalian gene circuit reveals antituberculosis compounds

21 January 2018

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Synthetic EthR inhibitors boost antituberculous activity of ethionamide

21 January 2018

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EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/FMB.11.46

1 reference

24 August 2017

1 reference

PubMed ID

21707310