(Q37895629)

24 August 2017

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title

Cell death-independent functions of granzymes: hit viruses where it hurts (English)

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24 August 2017

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1

Robert van Domselaar

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24 August 2017

2

Niels Bovenschen

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24 August 2017

language of work or name

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29 June 2011

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Reviews in Medical Virology

24 August 2017

published in

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24 August 2017

volume

21

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24 August 2017

issue

5

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24 August 2017

page(s)

301-314

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Decoding the patterns of self and nonself by the innate immune system

24 August 2017

cites work

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Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

21 January 2018

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Antiviral actions of interferons

21 January 2018

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Viruses and interferon: a fight for supremacy

21 January 2018

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Up on the tightrope: natural killer cell activation and inhibition

21 January 2018

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Death by a thousand cuts: granzyme pathways of programmed cell death

21 January 2018

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Orphan granzymes find a home

21 January 2018

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Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells

21 January 2018

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Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death

21 January 2018

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Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis

21 January 2018

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Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks

21 January 2018

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HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A

21 January 2018

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Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

21 January 2018

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Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70.

21 January 2018

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Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B.

21 January 2018

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Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

21 January 2018

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Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis

21 January 2018

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Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program

21 January 2018

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Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity

21 January 2018

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Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells

21 January 2018

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Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A.

21 January 2018

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Valosin-containing protein cleavage by granzyme K accelerates an endoplasmic reticulum stress leading to caspase-independent cytotoxicity of target tumor cells.

21 January 2018

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Ignition of p53 bomb sensitizes tumor cells to granzyme K-mediated cytolysis.

21 January 2018

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Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death.

21 January 2018

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NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network

21 January 2018

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Nucleophosmin is cleaved and inactivated by the cytotoxic granule protease granzyme M during natural killer cell-mediated killing

21 January 2018

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Granzyme M mediates a novel form of perforin-dependent cell death

21 January 2018

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Biology of granzyme M: a serine protease with unique features

21 January 2018

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Heat shock protein 75 (TRAP1) antagonizes reactive oxygen species generation and protects cells from granzyme M-mediated apoptosis.

21 January 2018

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Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells

21 January 2018

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Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation

21 January 2018

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The major human and mouse granzymes are structurally and functionally divergent

21 January 2018

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Human and mouse granzyme A induce a proinflammatory cytokine response.

21 January 2018

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Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia

21 January 2018

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Non-cytotoxic antiviral activities of granzymes in the context of the immune antiviral state.

21 January 2018

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Target protease specificity of the viral serpin CrmA. Analysis of five caspases

21 January 2018

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Inhibition of human caspases by peptide-based and macromolecular inhibitors

21 January 2018

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Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.

21 January 2018

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Crystal structure of viral serpin crmA provides insights into its mechanism of cysteine proteinase inhibition

21 January 2018

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Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex

21 January 2018

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Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex.

21 January 2018

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Mutational analyses of the p35-caspase interaction. A bowstring kinetic model of caspase inhibition by p35.

21 January 2018

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The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis.

21 January 2018

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Baculovirus apoptotic suppressor P49 is a substrate inhibitor of initiator caspases resistant to P35 in vivo

21 January 2018

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Adenovirus L4-100K assembly protein is a granzyme B substrate that potently inhibits granzyme B-mediated cell death

21 January 2018

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Baculoviruses and apoptosis: the good, the bad, and the ugly

21 January 2018

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Mechanisms of caspase activation and inhibition during apoptosis

21 January 2018

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Viral subversion of apoptotic enzymes: escape from death row.

21 January 2018

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Mitochondria: releasing power for life and unleashing the machineries of death

21 January 2018

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Viral Bcl-2 homologs and their role in virus replication and associated diseases

21 January 2018

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Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins

21 January 2018

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The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein

21 January 2018

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The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins

21 January 2018

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A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2.

21 January 2018

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Epstein-Barr virus BALF1 is a BCL-2-like antagonist of the herpesvirus antiapoptotic BCL-2 proteins

21 January 2018

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Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death

21 January 2018

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A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak

21 January 2018

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A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation

21 January 2018

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Human cytomegalovirus UL38 protein blocks apoptosis

21 January 2018

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Human cytomegalovirus major immediate-early proteins and simian virus 40 large T antigen can inhibit apoptosis through activation of the phosphatidylinositide 3'-OH kinase pathway and the cellular kinase Akt.

21 January 2018

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Modulation of host cell stress responses by human cytomegalovirus

21 January 2018

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Complex I binding by a virally encoded RNA regulates mitochondria-induced cell death

21 January 2018

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Viral latency and its regulation: lessons from the gamma-herpesviruses

21 January 2018

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Noncytotoxic lytic granule-mediated CD8+ T cell inhibition of HSV-1 reactivation from neuronal latency

21 January 2018

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The herpes simplex virus type 1 latency-associated transcript can protect neuron-derived C1300 and Neuro2A cells from granzyme B-induced apoptosis and CD8 T-cell killing

21 January 2018

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A secretable serine proteinase with highly restricted specificity from cytolytic T lymphocytes inactivates retrovirus-associated reverse transcriptase

21 January 2018

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Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition

21 January 2018

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Immunobiology of human cytomegalovirus: from bench to bedside.

21 January 2018

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Functional analysis of granzyme M and its role in immunity to infection

21 January 2018

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UL82 virion protein activates expression of immediate early viral genes in human cytomegalovirus-infected cells

21 January 2018

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Proteasome-dependent, ubiquitin-independent degradation of Daxx by the viral pp71 protein in human cytomegalovirus-infected cells

21 January 2018

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Role of the cellular protein hDaxx in human cytomegalovirus immediate-early gene expression

21 January 2018

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Human cytomegalovirus (HCMV) UL82 gene product (pp71) relieves hDaxx-mediated repression of HCMV replication

21 January 2018

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Inactivating a cellular intrinsic immune defense mediated by Daxx is the mechanism through which the human cytomegalovirus pp71 protein stimulates viral immediate-early gene expression

21 January 2018

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Human Daxx-mediated repression of human cytomegalovirus gene expression correlates with a repressive chromatin structure around the major immediate early promoter

21 January 2018

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Functional interaction between the pp71 protein of human cytomegalovirus and the PML-interacting protein human Daxx

21 January 2018

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Human cytomegalovirus gene expression is silenced by Daxx-mediated intrinsic immune defense in model latent infections established in vitro

21 January 2018

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Nuclear Localization of Tegument-Delivered pp71 in Human Cytomegalovirus-Infected Cells Is Facilitated by One or More Factors Present in Terminally Differentiated Fibroblasts

21 January 2018

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Human CD8(+) T-cell differentiation in response to viruses

21 January 2018

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Selective retention of herpes simplex virus-specific T cells in latently infected human trigeminal ganglia

21 January 2018

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Latent herpesvirus infection in human trigeminal ganglia causes chronic immune response

21 January 2018

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Gamma interferon can block herpes simplex virus type 1 reactivation from latency, even in the presence of late gene expression

21 January 2018

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Activation of immediate-early, early, and late promoters by temperature-sensitive and wild-type forms of herpes simplex virus type 1 protein ICP4

21 January 2018

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Binding of ICP4, TATA-binding protein, and RNA polymerase II to herpes simplex virus type 1 immediate-early, early, and late promoters in virus-infected cells

21 January 2018

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Proteomic profiling of proteases: tools for granzyme degradomics

21 January 2018

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Cleavage of La protein by granzyme H induces cytoplasmic translocation and interferes with La-mediated HCV-IRES translational activity

21 January 2018

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21 January 2018

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Functional characterization of the interaction between human La and hepatitis B virus RNA.

21 January 2018

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La protein binds the predicted loop structures in the 3' non-coding region of Japanese encephalitis virus genome: role in virus replication

21 January 2018

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La protein can simultaneously bind to both 3'- and 5'-noncoding regions of Japanese encephalitis virus genome

21 January 2018

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La protein required for internal ribosome entry site-directed translation is a potential therapeutic target for hepatitis C virus replication

21 January 2018

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Structural Determinant of Human La Protein Critical for Internal Initiation of Translation of Hepatitis C Virus RNA

21 January 2018

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Two Novel Classes of Small Ribonucleoproteins Detected by Antibodies Associated with Lupus Erythematosus

21 January 2018

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Ribonucleoprotein complexes as autoantigens

21 January 2018

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Phosphorylation of the human La antigen on serine 366 can regulate recycling of RNA polymerase III transcription complexes

21 January 2018

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The SET complex acts as a barrier to autointegration of HIV-1

21 January 2018

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The road to chromatin - nuclear entry of retroviruses

21 January 2018

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Involvement of template-activating factor I/SET in transcription of adenovirus early genes as a positive-acting factor

21 January 2018

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A proteomic approach for the discovery of protease substrates

21 January 2018

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Host heterogeneous ribonucleoprotein K (hnRNP K) as a potential target to suppress hepatitis B virus replication

21 January 2018

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Heterogeneous nuclear ribonuclear protein K interacts with the enterovirus 71 5' untranslated region and participates in virus replication

21 January 2018

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HIV Nef enhances Tat-mediated viral transcription through a hnRNP-K-nucleated signaling complex

21 January 2018

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Alterations in actin cytoskeletal assembly and junctional protein complexes in human endothelial cells induced by dengue virus infection and mimicry of leukocyte transendothelial migration

21 January 2018

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Vimentin interacts with heterogeneous nuclear ribonucleoproteins and dengue nonstructural protein 1 and is important for viral replication and release

21 January 2018

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Interaction between herpes simplex virus type 1 IE63 protein and cellular protein p32.

21 January 2018

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The multifunctional herpes simplex virus IE63 protein interacts with heterogeneous ribonucleoprotein K and with casein kinase 2

21 January 2018

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The heterogeneous nuclear ribonucleoprotein K is important for Herpes simplex virus-1 propagation

21 January 2018

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African swine fever virus protein p30 interaction with heterogeneous nuclear ribonucleoprotein K (hnRNP-K) during infection

21 January 2018

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Human herpesvirus 6 immediate-early 2 protein interacts with heterogeneous ribonucleoprotein K and casein kinase 2.

21 January 2018

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Complementary positional proteomics for screening substrates of endo- and exoproteases

21 January 2018

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The nucleolus--a gateway to viral infection?

21 January 2018

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RNA viruses: hijacking the dynamic nucleolus

21 January 2018

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Selective cleavage of nucleolar autoantigen B23 by granzyme B in differentiated vascular smooth muscle cells: insights into the association of specific autoantibodies with distinct disease phenotypes

21 January 2018

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The nucleolar phosphoprotein B23 interacts with hepatitis delta antigens and modulates the hepatitis delta virus RNA replication.

21 January 2018

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Identification of nucleophosmin/B23, an acidic nucleolar protein, as a stimulatory factor for in vitro replication of adenovirus DNA complexed with viral basic core proteins.

21 January 2018

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Physical and functional interaction between a nucleolar protein nucleophosmin/B23 and adenovirus basic core proteins

21 January 2018

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Nucleolar protein B23 interacts with Japanese encephalitis virus core protein and participates in viral replication

21 January 2018

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Analysis of protein processing by N-terminal proteomics reveals novel species-specific substrate determinants of granzyme B orthologs

21 January 2018

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Nucleolin is required for an efficient herpes simplex virus type 1 infection.

21 January 2018

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The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics

21 January 2018

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Identification of {alpha}-tubulin as a granzyme B substrate during CTL-mediated apoptosis

21 January 2018

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Molecular motors hijacking by intracellular pathogens.

21 January 2018

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Viral stop-and-go along microtubules: taking a ride with dynein and kinesins

21 January 2018

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Granzymes in cancer and immunity

21 January 2018

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Functional dissection of the granzyme family: cell death and inflammation.

21 January 2018

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Granzyme A is an interleukin 1 beta-converting enzyme

21 January 2018

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Mouse granzyme K has pro-inflammatory potential.

21 January 2018

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A role for granzyme M in TLR4-driven inflammation and endotoxicosis.

21 January 2018

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Delivery and therapeutic potential of human granzyme B.

21 January 2018

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Granzyme B delivery via perforin is restricted by size, but not by heparan sulfate-dependent endocytosis

21 January 2018

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African swine fever virus IAP homologue inhibits caspase activation and promotes cell survival in mammalian cells.

21 January 2018

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Amsacta moorei Entomopoxvirus inhibitor of apoptosis suppresses cell death by binding Grim and Hid

21 January 2018

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Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin

21 January 2018

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African swine fever virus gene A179L, a viral homologue of bcl-2, protects cells from programmed cell death

21 January 2018

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Inhibition of apoptosis by the African swine fever virus Bcl-2 homologue: role of the BH1 domain

21 January 2018

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Kaposi's sarcoma-associated herpesvirus encodes a functional Bcl-2 homologue

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/RMV.697

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24 August 2017

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