(Q46211971)

20 December 2017

title

Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A. (English)

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20 December 2017

author

Bart Devreese

6

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20 December 2017

Jos Joore

7

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20 December 2017

Isabel Vandenberghe

5

object named as

Isabel Vandenberghe

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20 December 2017

author name string

Niels Bovenschen

1

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20 December 2017

Razi Quadir

2

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20 December 2017

A Lotte van den Berg

3

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20 December 2017

Arjan B Brenkman

4

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20 December 2017

J Alain Kummer

8

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20 December 2017

language of work or name

English

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publication date

5 December 2008

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20 December 2017

Journal of Biological Chemistry

published in

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20 December 2017

volume

284

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20 December 2017

issue

6

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20 December 2017

page(s)

3504-3512

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20 December 2017

The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal

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Death by a thousand cuts: granzyme pathways of programmed cell death

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Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis

21 January 2018

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Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor

21 January 2018

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Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis

21 January 2018

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Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death

21 January 2018

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HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A

21 January 2018

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Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

21 January 2018

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Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70.

21 January 2018

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Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells

21 January 2018

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Generation of antigenic peptides by lymphocyte granule serine proteases (granzymes).

21 January 2018

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Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes

21 January 2018

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Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity

21 January 2018

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Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells

21 January 2018

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Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis

21 January 2018

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Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks

21 January 2018

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NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network

21 January 2018

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Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1

21 January 2018

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The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity

21 January 2018

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Crystal structure of the apoptosis-inducing human granzyme A dimer

21 January 2018

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The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features

21 January 2018

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hnRNP K: one protein multiple processes

21 January 2018

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The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics

21 January 2018

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Identification of {alpha}-tubulin as a granzyme B substrate during CTL-mediated apoptosis

21 January 2018

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Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death.

21 January 2018

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Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors

21 January 2018

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Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast cell tryptase

21 January 2018

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Microtubules as a target for anticancer drugs

21 January 2018

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Loss-of-function screening by randomized intracellular antibodies: identification of hnRNP-K as a potential target for metastasis

21 January 2018

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mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end.

21 January 2018

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Multiple and specific mRNA processing targets for the major human hnRNP proteins

21 January 2018

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Viral stop-and-go along microtubules: taking a ride with dynein and kinesins

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M806716200

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20 December 2017

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20 December 2017