(Q37896029)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21717585%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

review article

1 reference

title

The recent updates of therapeutic approaches against aβ for the treatment of Alzheimer's disease (English)

1 reference

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6 February 2020

0 references

3

1 reference

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6 February 2020

author name string

Shucai Ling

1

1 reference

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6 February 2020

Jing Zhou

2

1 reference

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6 February 2020

Zhiying Hu

4

1 reference

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6 February 2020

Marong Fang

5

1 reference

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6 February 2020

publication date

29 June 2011

1 reference

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6 February 2020

published in

The Anatomical Record

1 reference

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6 February 2020

volume

294

1 reference

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6 February 2020

issue

8

1 reference

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6 February 2020

page(s)

1307-1318

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Immunodominant epitope and properties of pyroglutamate-modified Abeta-specific antibodies produced in rabbits

6 February 2020

cites work

1 reference

The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice

21 January 2018

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Vaccination of Alzheimer's model mice with Abeta derivative in alum adjuvant reduces Abeta burden without microhemorrhages

21 January 2018

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The impact of microRNAs on protein output

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Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation

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Searching for MIND: microRNAs in neurodegenerative diseases.

21 January 2018

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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MicroRNAs: genomics, biogenesis, mechanism, and function

21 January 2018

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Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease

21 January 2018

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Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

21 January 2018

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A new role for microRNA pathways: modulation of degeneration induced by pathogenic human disease proteins.

21 January 2018

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Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: statistical reliability and functional correlation

21 January 2018

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Cultured cell and transgenic mouse models for tau pathology linked to beta-amyloid

21 January 2018

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Inhibiting β-secretase activity in Alzheimer's disease cell models with single-chain antibodies specifically targeting APP.

21 January 2018

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MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1.

21 January 2018

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Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

21 January 2018

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Pathophysiological roles of amyloidogenic carboxy-terminal fragments of the beta-amyloid precursor protein in Alzheimer's disease

21 January 2018

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Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics

21 January 2018

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Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells

21 January 2018

1 reference

Design and synthesis of 1,4-dihydropyridine derivatives as BACE-1 inhibitors

21 January 2018

1 reference

Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by us

21 January 2018

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BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296

21 January 2018

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Abeta DNA vaccination for Alzheimer's disease: focus on disease prevention

21 January 2018

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Selective disruption of the cerebral neocortex in Alzheimer's disease

21 January 2018

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Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease.

21 January 2018

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Regulatory mechanisms of microRNAs involvement in cancer

21 January 2018

1 reference

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase

21 January 2018

1 reference

Evidence for natural antisense transcript-mediated inhibition of microRNA function

21 January 2018

1 reference

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

21 January 2018

1 reference

Regulation of Alzheimer's disease amyloid-beta formation by casein kinase I

21 January 2018

1 reference

gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site

21 January 2018

1 reference

Most mammalian mRNAs are conserved targets of microRNAs

21 January 2018

1 reference

Beta-secretase activity increases with aging in human, monkey, and mouse brain.

21 January 2018

1 reference

Transport characteristics of peptides and peptidomimetics: II. Hydroxyethylamine bioisostere-containing peptidomimetics as substrates for the oligopeptide transporter and P-glycoprotein in the intestinal mucosa.

21 January 2018

1 reference

Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch

21 January 2018

1 reference

Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase).

21 January 2018

1 reference

miRNA genetic alterations in human cancers

21 January 2018

1 reference

Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models

21 January 2018

1 reference

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

21 January 2018

1 reference

Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

1 reference

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

21 January 2018

1 reference

MicroRNA regulation of Alzheimer's Amyloid precursor protein expression.

21 January 2018

1 reference

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression

21 January 2018

1 reference

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

21 January 2018

1 reference

In vitro Pb exposure disturbs the balance between Aβ production and elimination: the role of AβPP and neprilysin

21 January 2018

1 reference

Progress in the development of nonpeptidomimetic BACE 1 inhibitors for Alzheimer's disease

21 January 2018

1 reference

Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo

21 January 2018

1 reference

MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression

21 January 2018

1 reference

Metabolism of amyloid-beta peptide and Alzheimer's disease

21 January 2018

1 reference

Metabolic regulation of brain Abeta by neprilysin.

21 January 2018

1 reference

Evidence for dimeric BACE-mediated APP processing.

21 January 2018

1 reference

MicroRNA biogenesis: coordinated cropping and dicing

21 January 2018

1 reference

Design and synthesis of potent beta-secretase (BACE1) inhibitors with P1' carboxylic acid bioisosteres

21 January 2018

1 reference

Design and synthesis of highly active Alzheimer's beta-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability

21 January 2018

1 reference

KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine

21 January 2018

1 reference

Antibody responses, amyloid-beta peptide remnants and clinical effects of AN-1792 immunization in patients with AD in an interrupted trial

21 January 2018

1 reference

Amyloid-beta is an antioxidant for lipoproteins in cerebrospinal fluid and plasma

21 January 2018

1 reference

The neuronal microRNA system

21 January 2018

1 reference

A microRNA array reveals extensive regulation of microRNAs during brain development

21 January 2018

1 reference

The structure and function of Alzheimer's gamma secretase enzyme complex.

21 January 2018

1 reference

The nuclear RNase III Drosha initiates microRNA processing

21 January 2018

1 reference

Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice.

21 January 2018

1 reference

Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application

21 January 2018

1 reference

Control of protein synthesis and mRNA degradation by microRNAs

21 January 2018

1 reference

MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice

21 January 2018

1 reference

Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus.

21 January 2018

1 reference

Nuclear export of microRNA precursors

21 January 2018

1 reference

Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5' UTR as in the 3' UTR

21 January 2018

1 reference

Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo

21 January 2018

1 reference

Structures for amyloid fibrils

21 January 2018

1 reference

Cofilin-mediated neurodegeneration in Alzheimer's disease and other amyloidopathies

21 January 2018

1 reference

Alzheimer's disease: clinical trials and drug development

21 January 2018

1 reference

Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF.

21 January 2018

1 reference

Neurodegenerative stimuli induce persistent ADF/cofilin-actin rods that disrupt distal neurite function

21 January 2018

1 reference

Neurobiology of Alzheimer's disease

21 January 2018

1 reference

Abeta-induced meningoencephalitis is IFN-gamma-dependent and is associated with T cell-dependent clearance of Abeta in a mouse model of Alzheimer's disease

21 January 2018

1 reference

Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease

21 January 2018

1 reference

In situ hybridization is a necessary experimental complement to microRNA (miRNA) expression profiling in the human brain

21 January 2018

1 reference

Gleevec inhibits β-amyloid production but not Notch cleavage

21 January 2018

1 reference

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

21 January 2018

1 reference

Targeting beta-amyloid pathology in Alzheimer's disease with Abeta immunotherapy

21 January 2018

1 reference

The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans

21 January 2018

1 reference

Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation

21 January 2018

1 reference

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

21 January 2018

1 reference

High affinity, bioavailable 3-Amino-1,4-benzodiazepine-Based γ-Secretase inhibitors

21 January 2018

1 reference

Beyond the neurotransmitter-focused approach in treating Alzheimer's disease: drugs targeting beta-amyloid and tau protein

21 January 2018

1 reference

MicroRNAs can regulate human APP levels.

21 January 2018

1 reference

A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

21 January 2018

1 reference

Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice

21 January 2018

1 reference

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

21 January 2018

1 reference

Reassessing the amyloid cascade hypothesis of Alzheimer's disease

21 January 2018

1 reference

Alzheimer's mechanisms in ischemic brain degeneration

21 January 2018

1 reference

A closer look at alpha-secretase

21 January 2018

1 reference

Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region

21 January 2018

1 reference

Interpretation and applicability of microRNA data to the context of Alzheimer's and age-related diseases

21 January 2018

1 reference

Alzheimer's disease beta-amyloid peptides are released in association with exosomes

21 January 2018

1 reference

The amyloid-beta precursor protein: integrating structure with biological function

21 January 2018

1 reference

Small RNAs in human brain development and disorders.

21 January 2018

1 reference

Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease

21 January 2018

1 reference

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

21 January 2018

1 reference

Imaging of amyloid beta in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism

21 January 2018

1 reference

Post-transcriptional regulation of amyloid precursor protein by microRNAs and RNA binding proteins.

21 January 2018

1 reference

The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production

21 January 2018

1 reference

Therapeutic potential of RNA interference for neurological disorders

21 January 2018

1 reference

Development of AFFITOPE vaccines for Alzheimer's disease (AD)--from concept to clinical testing

21 January 2018

1 reference

Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta

21 January 2018

1 reference

Widespread changes in protein synthesis induced by microRNAs

21 January 2018

1 reference

Presenilin: running with scissors in the membrane

21 January 2018

1 reference

Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation

21 January 2018

1 reference

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease

21 January 2018

1 reference

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

Regulation of mammalian microRNA processing and function by cellular signaling and subcellular localization

21 January 2018

1 reference

In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs.

21 January 2018

1 reference

Design and development of non-fibrillar amyloid beta as a potential Alzheimer vaccine.

21 January 2018

1 reference

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

21 January 2018

1 reference

Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice

21 January 2018

1 reference

Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

21 January 2018

1 reference

Structural and dynamic features of Alzheimer's Abeta peptide in amyloid fibrils studied by site-directed spin labeling.

21 January 2018

1 reference

Alternative Abeta immunotherapy approaches for Alzheimer's disease

21 January 2018

1 reference

Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model

21 January 2018

1 reference

MicroRNA: biogenetic and functional mechanisms and involvements in cell differentiation and cancer

21 January 2018

1 reference

RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine.

21 January 2018

1 reference

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

Architecture of a validated microRNA::target interaction.

21 January 2018

1 reference

Novel huprine derivatives with inhibitory activity toward β-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates

21 January 2018

1 reference

MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons

21 January 2018

1 reference

miR-106b aberrantly expressed in a double transgenic mouse model for Alzheimer's disease targets TGF-β type II receptor

21 January 2018

1 reference

Genome-wide transcriptional profiling reveals microRNA-correlated genes and biological processes in human lymphoblastoid cell lines

21 January 2018

1 reference

The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1.

21 January 2018

1 reference

miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation

21 January 2018

1 reference

Correlation of expression profiles between microRNAs and mRNA targets using NCI-60 data

21 January 2018

1 reference

Physicochemical characteristics of soluble oligomeric Abeta and their pathologic role in Alzheimer's disease.

21 January 2018

1 reference

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations.

21 January 2018

1 reference

Beta-amyloid protein promotes neuritic branching in hippocampal cultures

21 January 2018

1 reference

Function, regulation and therapeutic properties of beta-secretase (BACE1).

21 January 2018

1 reference

New methods to explore marine resources for Alzheimer's therapeutics.

21 January 2018

1 reference

Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 allele.

21 January 2018

1 reference

Vaccination as a therapeutic approach to Alzheimer's disease.

21 January 2018

1 reference

Immunological and anti-chaperone therapeutic approaches for Alzheimer disease

21 January 2018

1 reference

Inhibition and modulation of gamma-secretase for Alzheimer's disease

21 January 2018

1 reference

21 January 2018

1 reference

MicroRNA-directed cleavage of HOXB8 mRNA

21 January 2018

1 reference

Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening

21 January 2018

1 reference

Principles of micro-RNA production and maturation

21 January 2018

1 reference

Hydrogen sulfide reduces mRNA and protein levels of β-site amyloid precursor protein cleaving enzyme 1 in PC12 cells

21 January 2018

1 reference

Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1.

21 January 2018

1 reference

Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

21 January 2018

1 reference

The blood-brain barrier in health and chronic neurodegenerative disorders

21 January 2018

1 reference

Divergent Synthesis of Multifunctional Molecular Probes To Elucidate the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors

21 January 2018

1 reference

Amyloid-β: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-β

21 January 2018

1 reference

Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors

21 January 2018

1 reference

C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)

21 January 2018

1 reference

Molecular medicine: MicroRNAs and the tell-tale heart

21 January 2018

1 reference