(Q36829275)

16 August 2017

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title

Cofilin-mediated neurodegeneration in Alzheimer's disease and other amyloidopathies (English)

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16 August 2017

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Michael T Maloney

1

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PubMed ID

17519504

16 August 2017

James R Bamburg

series ordinal

2

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16 August 2017

1 February 2007

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16 August 2017

Molecular Neurobiology

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16 August 2017

35

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16 August 2017

1

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16 August 2017

21-44

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https://scigraph.springernature.com/pub.10.1007/bf02700622

16 August 2017

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cites work

Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments

1 reference

https://api.crossref.org/works/10.1007%2FBF02700622

Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02700622

Intracellular A beta 1-42 aggregates stimulate the accumulation of stable, insoluble amyloidogenic fragments of the amyloid precursor protein in transfected cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02700622

Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02700622

Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02700622

Alzheimer's presenile dementia, senile dementia of Alzheimer type and Down's syndrome in middle age form an age related continuum of pathological changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02700622

Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02700622

Amyloid β accumulation in axons after traumatic brain injury in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02700622

Long-term accumulation of amyloid-beta, beta-secretase, presenilin-1, and caspase-3 in damaged axons following brain trauma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02700622

Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02700622

Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02700622

Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02700622

Statin blocks Rho/Rho-kinase signalling and disrupts the actin cytoskeleton: relationship to enhancement of LPS-mediated nitric oxide synthesis in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02700622

Mitochondria in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02700622

Characterization of neuronal dystrophy induced by fibrillar amyloid beta: implications for Alzheimer's disease.

21 January 2018

1 reference

12 December 2020

A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1.

1 reference

12 December 2020

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

1 reference

12 December 2020

Rho proteins: linking signaling with membrane trafficking

1 reference

12 December 2020

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

12 December 2020

Hypoxia signaling to genes: significance in Alzheimer's disease

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12 December 2020

Embryonic genes expressed in Alzheimer's disease brains

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12 December 2020

Novel actin cytoskeleton: actin tubules

1 reference

12 December 2020

Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis.

1 reference

12 December 2020

Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome.

1 reference

12 December 2020

App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome

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12 December 2020

Nuclear actin bundles in Amoeba, Dictyostelium and human HeLa cells induced by dimethyl sulfoxide

1 reference

12 December 2020

Linking molecular motors to Alzheimer's disease

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12 December 2020

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.

1 reference

12 December 2020

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

1 reference

12 December 2020

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

1 reference

12 December 2020

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

12 December 2020

The actin cytoskeleton in ageing and apoptosis.

1 reference

12 December 2020

Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus.

1 reference

12 December 2020

Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

1 reference

12 December 2020

Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease.

1 reference

12 December 2020

Paxillin and focal adhesion signalling

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12 December 2020

NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals

1 reference

12 December 2020

A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease.

1 reference

12 December 2020

The voltage-dependent anion channel: an essential player in apoptosis

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12 December 2020

Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC

1 reference

12 December 2020

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

12 December 2020

Increased BACE1 maturation contributes to the pathogenesis of Alzheimer's disease in Down syndrome.

1 reference

12 December 2020

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

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12 December 2020

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

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12 December 2020

Mitochondrial translocation of cofilin is an early step in apoptosis induction.

1 reference

12 December 2020

The beta-amyloid-related proteins presenilin 1 and BACE1 are axonally transported to nerve terminals in the brain

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12 December 2020

Amyloid beta protein precursor accumulates in swollen neurites throughout rat brain with aging.

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12 December 2020

The branch point enzyme of the mevalonate pathway for protein prenylation is overexpressed in the ob/ob mouse and induced by adipogenesis

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12 December 2020

Cooperative effects of cofilin (ADF) on actin structure suggest allosteric mechanism of cofilin function

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12 December 2020

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

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12 December 2020

Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release

1 reference

12 December 2020

Cofilin phosphatases and regulation of actin dynamics

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12 December 2020

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

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12 December 2020

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity.

1 reference

12 December 2020

Analysis of the interactions of actin depolymerizing factor with G- and F-actin

1 reference

12 December 2020

Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice.

1 reference

12 December 2020

The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention.

1 reference

12 December 2020

Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease

1 reference

12 December 2020

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1 reference

12 December 2020

Histological Changes induced in Sympathetic, Motor, and Sensory Nerve Cells by Functional Activity (Preliminary note)

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12 December 2020

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

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12 December 2020

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1 reference

12 December 2020

Live dynamics of Dictyostelium cofilin suggests a role in remodeling actin latticework into bundles

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12 December 2020

Phosphorylation of rat brain mitochondrial voltage-dependent anion as a potential tool to control leakage of cytochrome c.

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12 December 2020

Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo.

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12 December 2020

Neurodegenerative stimuli induce persistent ADF/cofilin-actin rods that disrupt distal neurite function

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12 December 2020

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

1 reference

12 December 2020

Methodological variables in the assessment of beta amyloid neurotoxicity

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12 December 2020

Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: a quantitative analysis across subregions of the basal forebrain

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12 December 2020

Actin depolymerizing factor (ADF/cofilin) enhances the rate of filament turnover: implication in actin-based motility

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12 December 2020

Actin-ATP hydrolysis is a major energy drain for neurons.

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12 December 2020

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

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12 December 2020

Alzheimer disease: plaques, tangles, and the basal forebrain

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12 December 2020

Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

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12 December 2020

C-terminal fragments of amyloid-beta peptide cause cholinergic axonal degeneration by a toxic effect rather than by physical injury in the nondemented human brain.

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12 December 2020

Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice.

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12 December 2020

Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics

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12 December 2020

Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase

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12 December 2020

The role of synaptic proteins in Alzheimer's disease

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12 December 2020

Colocalization of ADF and cofilin in intranuclear actin rods of cultured muscle cells

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12 December 2020

Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.

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12 December 2020

Divergent roles of GSK3 and CDK5 in APP processing

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12 December 2020

Plasma lipids and cholesterol esterification in Alzheimer's disease.

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12 December 2020

Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin

1 reference

12 December 2020

Formation of actin-ADF/cofilin rods transiently retards decline of mitochondrial potential and ATP in stressed neurons.

1 reference

12 December 2020

Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.

1 reference

12 December 2020

Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1.

1 reference

12 December 2020

Presenilin-1 and the amyloid precursor protein are transported bidirectionally in the sciatic nerve of adult rat

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12 December 2020

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

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12 December 2020

Overexpression of LIM kinase 1 renders resistance to apoptosis in PC12 cells by inhibition of caspase activation

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12 December 2020

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

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12 December 2020

Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments

1 reference

12 December 2020

Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells.

1 reference

12 December 2020

Identification of an upstream regulatory pathway controlling actin-mediated apoptosis in yeast

1 reference

12 December 2020

Dephosphorylation of cofilin accompanies heat shock-induced nuclear accumulation of cofilin

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12 December 2020

Aberrant activation of focal adhesion proteins mediates fibrillar amyloid beta-induced neuronal dystrophy.

1 reference

12 December 2020

Cholesterol decreases secretion of the secreted form of amyloid precursor protein by interfering with glycosylation in the protein secretory pathway

1 reference

12 December 2020

Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture

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12 December 2020

Accelerated ageing or selective neuronal loss as an important cause of dementia?

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12 December 2020

Oligomeric states of the voltage-dependent anion channel and cytochrome c release from mitochondria

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12 December 2020

A role for actin in aging and apoptosis

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12 December 2020

Expression of calcipressin1, an inhibitor of the phosphatase calcineurin, is altered with aging and Alzheimer's disease.

1 reference

12 December 2020

Cofilin expression induces cofilin-actin rod formation and disrupts synaptic structure and function in Aplysia synapses.

1 reference

12 December 2020

Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage

1 reference

12 December 2020

Beta-secretase-cleaved amyloid precursor protein accumulates at actin inclusions induced in neurons by stress or amyloid beta: a feedforward mechanism for Alzheimer's disease.

1 reference

12 December 2020

Bridging cognition, the brain and molecular genetics: evidence from Williams syndrome

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12 December 2020

ADF/cofilin and actin dynamics in disease

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12 December 2020

BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome

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12 December 2020

Neuronal membrane cholesterol loss enhances amyloid peptide generation

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12 December 2020

Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin

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12 December 2020

Glutamate toxicity in chronic neurodegenerative disease.

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12 December 2020

Nerve growth factor signaling, neuroprotection, and neural repair

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12 December 2020

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12 December 2020

Pathways towards and away from Alzheimer's disease

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12 December 2020

Synaptic slaughter in Alzheimer's disease

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12 December 2020

A role for the actin cytoskeleton in cell death and aging in yeast.

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12 December 2020

Mitochondria take center stage in aging and neurodegeneration

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12 December 2020

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

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12 December 2020

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

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12 December 2020

Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses.

1 reference

12 December 2020

Heat shock induction of intranuclear actin rods in cultured mammalian cells

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12 December 2020

The KKRKK sequence is involved in heat shock-induced nuclear translocation of the 18-kDa actin-binding protein, cofilin

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12 December 2020

Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

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12 December 2020

A specific amyloid-beta protein assembly in the brain impairs memory

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12 December 2020

Cofilin is a component of intranuclear and cytoplasmic actin rods induced in cultured cells

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12 December 2020

The role of cholesterol in the biosynthesis of beta-amyloid

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12 December 2020

Central cholinergic functions in human amyloid precursor protein knock-in/presenilin-1 transgenic mice

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12 December 2020

Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.

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12 December 2020

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

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12 December 2020

Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red.

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12 December 2020

Phosphorylation of Ser-3 of cofilin regulates its essential function on actin

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12 December 2020

Quantitative proteomic analysis of mitochondria from primary neuron cultures treated with amyloid beta peptide

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12 December 2020

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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12 December 2020

Integrins and actin filaments: reciprocal regulation of cell adhesion and signaling

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12 December 2020

Abnormalities of the nucleus basalis in Down's syndrome

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12 December 2020

Glutamic acid and Alzheimer's disease

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12 December 2020

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

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12 December 2020

Cellular mechanisms for amyloid beta-protein activation of rat cholinergic basal forebrain neurons

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12 December 2020

Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin

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12 December 2020

Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK

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12 December 2020

Calcium-regulated signaling pathways: role in amyloid beta-induced synaptic dysfunction

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12 December 2020

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

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12 December 2020

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

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12 December 2020

Molecular mapping of Alzheimer-type dementia in Down's syndrome.

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12 December 2020

Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism.

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12 December 2020

Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion

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12 December 2020

Glutamate and Amyloid β-Protein Rapidly Inhibit Fast Axonal Transport in Cultured Rat Hippocampal Neurons by Different Mechanisms

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12 December 2020

Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide.

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12 December 2020

Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

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12 December 2020

LIMK1 regulates Golgi dynamics, traffic of Golgi-derived vesicles, and process extension in primary cultured neurons

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12 December 2020

Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

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12 December 2020

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

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12 December 2020

Cofilin changes the twist of F-actin: implications for actin filament dynamics and cellular function

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12 December 2020

Mitochondrial abnormalities in Alzheimer's disease.

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12 December 2020

Regulation of Rho and Rac signaling to the actin cytoskeleton by paxillin during Drosophila development

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12 December 2020

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

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12 December 2020

Isoprenoids and Alzheimer's disease: a complex relationship

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12 December 2020

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

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12 December 2020

Identifiers

DOI

10.1007/BF02700622

1 reference

16 August 2017

1 reference

PubMed ID

17519504