(Q37926912)

25 August 2017

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title

Cholesterol metabolism in Huntington disease (English)

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25 August 2017

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2

Michael R Hayden

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25 August 2017

Joanna M Karasinska

1

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25 August 2017

language of work or name

English

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publication date

6 September 2011

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25 August 2017

published in

Nature Reviews Neurology

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25 August 2017

volume

7

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25 August 2017

issue

10

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25 August 2017

page(s)

561-572

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

25 August 2017

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Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro

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Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

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Malformation syndromes caused by disorders of cholesterol synthesis

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Lipid imbalance in the neurological disorder, Niemann-Pick C disease

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Mechanisms for cellular cholesterol transport: defects and human disease

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Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes.

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Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

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Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment

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The measurement of the exchangeable pools of cholesterol in the baboon

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A new function for the LDL receptor: transcytosis of LDL across the blood-brain barrier

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Scavenger receptor class B, type I is expressed in porcine brain capillary endothelial cells and contributes to selective uptake of HDL-associated vitamin E

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ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells

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Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells

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Direct evidence of abca1-mediated efflux of cholesterol at the mouse blood–brain barrier

31 March 2020

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Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function

31 March 2020

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Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis.

31 March 2020

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Role of cholesterol in synapse formation and function

31 March 2020

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Survival of adult neurons lacking cholesterol synthesis in vivo

31 March 2020

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Neurobiology. Cholesterol--making or breaking the synapse

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

CNS synaptogenesis promoted by glia-derived cholesterol

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Cholesterol homeostasis in neurons and glial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Role of lipoproteins in the delivery of lipids to axons during axonal regeneration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Lipoprotein uptake by neuronal growth cones in vitro

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Nerve injury stimulates the secretion of apolipoprotein E by nonneuronal cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

ApoE promotes the proteolytic degradation of Abeta

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

A novel intronic polymorphism of ABCA1 gene reveals risk for sporadic Alzheimer's disease in Chinese.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Association of genetic variants of ABCA1 with Alzheimer's disease risk

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Cholesterol synthesis in cultured skin fibroblasts from patients with Huntington's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Whole body cholesterol metabolism is impaired in Huntington's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Progressive dysfunction of the cholesterol biosynthesis pathway in the R6/2 mouse model of Huntington's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Selective degeneration in YAC mouse models of Huntington disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

HPLC method for quantitation of cholesterol and four of its major oxidation products in muscle and liver tissues

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

A sensitive enzymatic method for determination of free and esterified tissue cholesterol

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Normal huntingtin function: an alternative approach to Huntington's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Huntingtin-protein interactions and the pathogenesis of Huntington's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

The hunt for huntingtin function: interaction partners tell many different stories

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Cooperation by sterol regulatory element-binding protein and Sp1 in sterol regulation of low density lipoprotein receptor gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

The SREBP pathway--insights from Insigs and insects

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Regulation of the mevalonate pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Brain-derived neurotrophic factor regulates cholesterol metabolism for synapse development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Brain-derived neurotrophic factor in neurodegenerative diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Lipid rafts and signal transduction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanisms

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

VIP21/caveolin is a cholesterol-binding protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Expression of caveolin-1 enhances cholesterol efflux in hepatic cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Impaired synaptic plasticity in mice carrying the Huntington's disease mutation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Dysregulation of intracellular dopamine stores revealed in the R6/2 mouse striatum

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Catecholamine exocytosis is diminished in R6/2 Huntington's disease model mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

SNARE proteins are highly enriched in lipid rafts in PC12 cells: implications for the spatial control of exocytosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Liver X receptors as integrators of metabolic and inflammatory signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Liver X receptor activation decreases the severity of experimental autoimmune encephalomyelitis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Expression profiling in APP23 mouse brain: inhibition of Abeta amyloidosis and inflammation in response to LXR agonist treatment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Activation of liver X receptors promotes neuroprotection and reduces brain inflammation in experimental stroke.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Treatment with LXR agonists after focal cerebral ischemia prevents brain damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Early and progressive accumulation of reactive microglia in the Huntington disease brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Neuroinflammation in Huntington's disease

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Lipid raft microdomains and neurotransmitter signalling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Phosphorylation Sites on Tau Identified by Nanoelectrospray Mass Spectrometry

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Recruitment of active glycogen synthase kinase-3 into neuronal lipid rafts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Huntington's disease: from molecular pathogenesis to clinical treatment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Statins for the treatment of dementia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Simvastatin reduces the association of NMDA receptors to lipid rafts: a cholesterol-mediated effect in neuroprotection.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Cholesterol-independent neuroprotective and neurotoxic activities of statins: perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

The liver X receptor: control of cellular lipid homeostasis and beyond Implications for drug design

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

MicroRNAs in CNS injury: potential roles and therapeutic implications

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

MiR-33 contributes to the regulation of cholesterol homeostasis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.132

Liver X receptors (LXRs). Part I: structure, function, regulation of activity, and role in lipid metabolism

31 March 2020

1 reference

12 December 2020

Biochemical studies in Huntington's chorea. II. Composition of blood lipids.

1 reference

12 December 2020

Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients

1 reference

12 December 2020

Association of higher levels of high-density lipoprotein cholesterol in elderly individuals and lower risk of late-onset Alzheimer disease

1 reference

12 December 2020

Nascent astrocyte particles differ from lipoproteins in CSF.

1 reference

12 December 2020

Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease

1 reference

12 December 2020

Effects of apolipoprotein E, beta-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro

1 reference

12 December 2020

Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta

1 reference

12 December 2020

10.1038/NRNEUROL.2011.132

Identifiers

DOI

1 reference

Dimensions Publication ID

25 August 2017

1040361371

0 references

1 reference