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IAPs: guardians of RIPK1
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scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
3252837
retrieved
25 August 2017
title
IAPs: guardians of RIPK1
(English)
1 reference
stated in
Europe PubMed Central
PMCID
3252837
retrieved
25 August 2017
author
Pascal Meier
object named as
P Meier
series ordinal
2
0 references
author name string
M Darding
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
3252837
retrieved
25 August 2017
publication date
18 November 2011
1 reference
stated in
Europe PubMed Central
PMCID
3252837
retrieved
25 August 2017
published in
Cell Death & Differentiation
1 reference
stated in
Europe PubMed Central
PMCID
3252837
retrieved
25 August 2017
volume
19
1 reference
stated in
Europe PubMed Central
PMCID
3252837
retrieved
25 August 2017
page(s)
58-66
1 reference
stated in
Europe PubMed Central
PMCID
3252837
retrieved
25 August 2017
issue
1
1 reference
stated in
Europe PubMed Central
PMCID
3252837
retrieved
25 August 2017
exact match
https://scigraph.springernature.com/pub.10.1038/cdd.2011.163
0 references
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cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms
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CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration
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6 September 2017
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Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis
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In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8
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6 September 2017
Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2.
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6 September 2017
Deubiquitinases in the regulation of NF-κB signaling
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Molecular mechanisms of necroptosis: an ordered cellular explosion
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IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer
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Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression
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6 September 2017
The BCL-2 family reunion
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6 September 2017
TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion
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6 September 2017
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6 September 2017
XIAP mediates NOD signaling via interaction with RIP2
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6 September 2017
Smac mimetics as new cancer therapeutics.
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6 September 2017
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
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6 September 2017
Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha
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6 September 2017
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis
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6 September 2017
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6 September 2017
Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.
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6 September 2017
Targeting the ubiquitin system in cancer therapy
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6 September 2017
Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation
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6 September 2017
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6 September 2017
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6 September 2017
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.
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6 September 2017
Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1)
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6 September 2017
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6 September 2017
Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation
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6 September 2017
c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation
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6 September 2017
TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.
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6 September 2017
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
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6 September 2017
TNF-alpha induces two distinct caspase-8 activation pathways
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6 September 2017
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation
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6 September 2017
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
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6 September 2017
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis
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6 September 2017
Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis
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6 September 2017
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6 September 2017
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6 September 2017
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6 September 2017
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6 September 2017
Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1
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6 September 2017
cFLIP regulation of lymphocyte activation and development
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6 September 2017
IAPs, RINGs and ubiquitylation
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6 September 2017
The pathophysiology of mitochondrial cell death
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6 September 2017
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6 September 2017
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6 September 2017
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6 September 2017
N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway
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6 September 2017
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6 September 2017
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6 September 2017
The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex
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6 September 2017
IAP proteins: blocking the road to death's door
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6 September 2017
Characterization of XIAP-deficient mice
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6 September 2017
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
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6 September 2017
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6 September 2017
NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP
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6 September 2017
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6 September 2017
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6 September 2017
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6 September 2017
NF-kappaB signals induce the expression of c-FLIP.
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6 September 2017
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6 September 2017
FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity
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14 September 2017
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14 September 2017
IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis
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14 September 2017
A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling
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14 September 2017
The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases
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14 September 2017
Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs.
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14 September 2017
IAP-antagonists exhibit non-redundant modes of action through differential DIAP1 binding
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14 September 2017
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14 September 2017
Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252837
retrieved
14 September 2017
Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252837
retrieved
23 June 2018
Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252837
retrieved
23 June 2018
ATM kinase activity modulates cFLIP protein levels: potential interplay between DNA damage signalling and TRAIL-induced apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252837
retrieved
1 September 2018
Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252837
retrieved
1 September 2018
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252837
retrieved
1 September 2018
NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252837
retrieved
1 September 2018
Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252837
retrieved
1 September 2018
Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252837
retrieved
1 September 2018
Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22095281
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/CDD.2011.163
1 reference
stated in
Europe PubMed Central
PMCID
3252837
retrieved
25 August 2017
Dimensions Publication ID
1042686291
0 references
PMCID
3252837
1 reference
stated in
Europe PubMed Central
PMCID
3252837
retrieved
25 August 2017
PubMed ID
22095281
1 reference
stated in
Europe PubMed Central
PMCID
3252837
retrieved
25 August 2017
ResearchGate publication ID
51807487
0 references
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