(Q37987879)

26 August 2017

The SOCS box-adapting proteins for ubiquitination and proteasomal degradation (English)

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26 August 2017

protein ubiquitination

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Edmond M Linossi

1

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PubMed ID

22362562

26 August 2017

Sandra E Nicholson

series ordinal

2

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26 August 2017

23 February 2012

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26 August 2017

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26 August 2017

64

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26 August 2017

4

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26 August 2017

316-323

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The emerging complexity of protein ubiquitination

26 August 2017

1 reference

TRIM proteins and cancer.

21 January 2018

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Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

21 January 2018

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Deubiquitinases in the regulation of NF-κB signaling

21 January 2018

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RING domain E3 ubiquitin ligases

21 January 2018

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VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

21 January 2018

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Twenty proteins containing a C-terminal SOCS box form five structural classes

21 January 2018

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SOCS regulation of the JAK/STAT signalling pathway

21 January 2018

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SOCS proteins, cytokine signalling and immune regulation

21 January 2018

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A family of cytokine-inducible inhibitors of signalling

21 January 2018

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Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C

21 January 2018

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Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

21 January 2018

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The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

21 January 2018

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The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

21 January 2018

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The SOCS Box Domain of SOCS3: Structure and Interaction with the ElonginBC-Cullin5 Ubiquitin Ligase

21 January 2018

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Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

21 January 2018

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Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase

21 January 2018

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The SOCS box: a tale of destruction and degradation

21 January 2018

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Structure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR Degradation

21 January 2018

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Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation

21 January 2018

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Structural assembly of cullin-RING ubiquitin ligase complexes

21 January 2018

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Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

21 January 2018

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Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex

21 January 2018

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The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.

21 January 2018

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Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

21 January 2018

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SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.

21 January 2018

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SOCS3 negatively regulates IL-6 signaling in vivo

21 January 2018

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Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.

21 January 2018

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The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo

21 January 2018

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The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo

21 January 2018

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The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression

21 January 2018

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Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.

21 January 2018

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Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.

21 January 2018

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The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.

21 January 2018

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Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation

21 January 2018

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SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

21 January 2018

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Suppressor of cytokine signaling (SOCS) 1 inhibits type I interferon (IFN) signaling via the interferon alpha receptor (IFNAR1)-associated tyrosine kinase Tyk2

21 January 2018

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Gigantism in mice lacking suppressor of cytokine signalling-2

21 January 2018

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The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels

21 January 2018

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Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2.

21 January 2018

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Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

21 January 2018

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c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130

21 January 2018

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Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation

21 January 2018

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Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor

21 January 2018

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Site-specific ubiquitination determines lysosomal sorting and signal attenuation of the granulocyte colony-stimulating factor receptor

21 January 2018

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SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation

21 January 2018

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Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans

21 January 2018

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Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling

21 January 2018

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Structural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin Ligase

21 January 2018

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SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation

21 January 2018

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ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes

21 January 2018

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ASB2 is an Elongin BC-interacting protein that can assemble with Cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex

21 January 2018

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A census of protein repeats

21 January 2018

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The ankyrin repeat: a diversity of interactions on a common structural framework

21 January 2018

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The E3 ubiquitin ligase specificity subunit ASB2beta is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation

21 January 2018

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ASB2 targets filamins A and B to proteasomal degradation

21 January 2018

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The E3 ubiquitin ligase specificity subunit ASB2α targets filamins for proteasomal degradation by interacting with the filamin actin-binding domain

21 January 2018

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Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor II

21 January 2018

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Expression of ankyrin repeat and suppressor of cytokine signaling box protein 4 (Asb-4) in proopiomelanocortin neurons of the arcuate nucleus of mice produces a hyperphagic, lean phenotype

21 January 2018

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Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation

21 January 2018

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Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation

21 January 2018

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ASB9 interacts with ubiquitous mitochondrial creatine kinase and inhibits mitochondrial function

21 January 2018

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d-Asb11 is an essential mediator of canonical Delta-Notch signalling

21 January 2018

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The novel gene asb11: a regulator of the size of the neural progenitor compartment

21 January 2018

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Essential role for the d-Asb11 cul5 Box domain for proper notch signaling and neural cell fate decisions in vivo

21 January 2018

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TLR regulation of SPSB1 controls inducible nitric oxide synthase induction.

21 January 2018

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The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation

21 January 2018

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Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins

21 January 2018

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Regulation of Drosophila vasa in vivo through paralogous cullin-RING E3 ligase specificity receptors

21 January 2018

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Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1

21 January 2018

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The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate

21 January 2018

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Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling.

21 January 2018

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The TEL-Jak2 oncoprotein induces Socs1 expression and altered cytokine response in Ba/F3 cells

21 January 2018

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Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.

21 January 2018

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Hepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3

21 January 2018

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ECSASB2 mediates MLL degradation during hematopoietic differentiation

21 January 2018

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Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes

21 January 2018

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A mechanism underlying NOTCH-induced and ubiquitin-mediated JAK3 degradation

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/IUB.1011

1 reference

26 August 2017

1 reference

PubMed ID

22362562