(Q37999788)

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From murine to human nude/SCID: the thymus, T-cell development and the missing link

scientific article published on 05 March 2012

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scholarly article

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Europe PubMed Central

26 August 2017

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10 October 2022

From murine to human nude/SCID: the thymus, T-cell development and the missing link (English)

1 reference

Europe PubMed Central

26 August 2017

DiGeorge syndrome

1 reference

6 July 2020

severe combined immunodeficiency

1 reference

6 July 2020

1 reference

18 October 2019

1 reference

22 December 2019

Claudio Pignata

8

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26 August 2017

Loredana Palamaro

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Loredana Palamaro

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Stefano Maio

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Anna Fusco

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Giuliana Giardino

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Giuliana Giardino

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Ilaria Vigliano

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Ilaria Vigliano

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Rosa Romano

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Leucio Iannace

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5 March 2012

15 references

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26 August 2017

14 February 2019

6 March 2019

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22 March 2019

24 March 2019

22 April 2019

17 June 2019

12 October 2019

18 October 2019

11 December 2019

22 December 2019

6 July 2020

6 February 2021

10 October 2022

Clinical and Developmental Immunology

15 references

Europe PubMed Central

26 August 2017

14 February 2019

6 March 2019

13 March 2019

22 March 2019

24 March 2019

22 April 2019

17 June 2019

12 October 2019

18 October 2019

11 December 2019

22 December 2019

6 July 2020

6 February 2021

10 October 2022

2012

1 reference

Europe PubMed Central

26 August 2017

467101

1 reference

Europe PubMed Central

26 August 2017

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Creative Commons Attribution 3.0 Unported

14 references

Europe PubMed Central

14 February 2019

Europe PubMed Central

6 March 2019

Europe PubMed Central

13 March 2019

Europe PubMed Central

22 March 2019

Europe PubMed Central

24 March 2019

Europe PubMed Central

22 April 2019

Europe PubMed Central

17 June 2019

Europe PubMed Central

12 October 2019

Europe PubMed Central

18 October 2019

Europe PubMed Central

11 December 2019

Europe PubMed Central

22 December 2019

Europe PubMed Central

6 July 2020

Europe PubMed Central

6 February 2021

Europe PubMed Central

10 October 2022

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on focus list of Wikimedia project

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Morphogenesis and maintenance of the 3D thymic medulla and prevention of nude skin phenotype require FoxN1 in pre- and post-natal K14 epithelium

1 reference

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Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy

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Expression of TCR alpha beta partly rescues developmental arrest and apoptosis of alpha beta T cells in Bcl11b-/- mice

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Mouse models of 22q11 deletion syndrome

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Journey through the thymus: stromal guides for T-cell development and selection

1 reference

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Cellular and molecular events during early thymus development

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Establishment and functioning of intrathymic microenvironments.

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Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly

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Helix-loop-helix proteins and lymphocyte development

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The repair of DNA damages/modifications during the maturation of the immune system: lessons from human primary immunodeficiency disorders and animal models.

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Reevaluating current models of thymic involution

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Aging and T cell development: interplay between progenitors and their environment

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6 September 2017

Controlling the thymic microenvironment.

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6 September 2017

Severe combined immunodeficiency. A model disease for molecular immunology and therapy

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Graves' disease in DiGeorge syndrome: patient report with a review of endocrine autoimmunity associated with 22q11.2 deletion

1 reference

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The role of CCL21 in recruitment of T-precursor cells to fetal thymi

1 reference

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Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions

1 reference

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Reduction in the developmental potential of intrathymic T cell progenitors with age

1 reference

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Critical functions for c-Myb at three checkpoints during thymocyte development

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1 reference

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T-cell development made simple

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1 reference

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Five years on the wings of fork head

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6 September 2017

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6 September 2017

Molecular definition of the 22q11 deletions in velo-cardio-facial syndrome

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6 September 2017

Velo-cardio-facial syndrome: frequency and extent of 22q11 deletions

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6 September 2017

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

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6 September 2017

Positive selection of thymocytes

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6 September 2017

Activation events during thymic selection

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6 September 2017

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14 September 2017

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14 September 2017

Functional interaction of common gamma-chain and growth hormone receptor signaling apparatus

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14 September 2017

Control points in early T-cell development

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14 September 2017

Male-to-male transmission of the velo-cardio-facial syndrome: a case report and review of 60 cases

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14 September 2017

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14 September 2017

Generation of macrophages from early T progenitors in vitro

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28 September 2017

RAG mutations in human B cell-negative SCID.

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28 September 2017

Regulation of thymocyte development from immature progenitors.

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28 September 2017

Early T lymphocyte progenitors

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28 September 2017

Biological function and distribution of human interleukin-12 receptor beta chain

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28 September 2017

Early alpha beta T cell development in the thymus of normal and genetically altered mice

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28 September 2017

Human skin cells support thymus-independent T cell development

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23 June 2018

Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling

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23 June 2018

Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice.

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23 June 2018

Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lck proximal promoter activity

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23 June 2018

Association between mouse nude gene expression and the initiation of epithelial terminal differentiation

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23 June 2018

The annual incidence of DiGeorge/velocardiofacial syndrome

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23 June 2018

Structure and function of the pre-T cell receptor

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23 June 2018

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303720

23 June 2018

Tissue interaction in the development of thymus lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303720

23 June 2018

Immunological responses of 'nude' mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303720

23 June 2018

Anomalies in the hormonal status of athymic nude mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303720

23 June 2018

The majority of CD4+8- thymocytes are functionally immature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303720

23 June 2018

The velo-cardio-facial syndrome: the spectrum of psychiatric problems and cognitive deterioration at adult age.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303720

31 August 2018

T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303720

31 August 2018

Formation of a functional thymus initiated by a postnatal epithelial progenitor cell.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303720

31 August 2018

Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303720

31 August 2018

Reduced thymic output, increased spontaneous apoptosis and oligoclonal B cells in polyethylene glycol-adenosine deaminase-treated patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303720

31 August 2018

BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303720

31 August 2018

Biased T-cell receptor repertoires in patients with chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303720

31 August 2018

Immunologic features of chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303720

31 August 2018

Identical mutations in RAG1 or RAG2 genes leading to defective V(D)J recombinase activity can cause either T-B-severe combined immune deficiency or Omenn syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303720

31 August 2018

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303720

31 August 2018

Apoptosis as a mechanism of peripheral blood mononuclear cell death after measles and varicella-zoster virus infections in children

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303720

31 August 2018

The product of the mouse nude locus, Whn, regulates the balance between epithelial cell growth and differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303720

31 August 2018

Two genetically separable steps in the differentiation of thymic epithelium.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303720

31 August 2018

Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303720

31 August 2018

T-cell lineage commitment and cytokine responses of thymic progenitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303720

31 August 2018

Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor γδ + gut intraepithelial lymphocytes

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F467101

21 January 2018

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F467101

21 January 2018

Absence of Thymus in a Mouse Mutant

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F467101

21 January 2018

The lymphoid tissues in mice with congenital aplasia of the thymus

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymus dysgenesis in nude (nu nu) mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenotypic analysis of thymocytes that express homing receptors for peripheral lymph nodes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reconstitution of the lymphocyte compartment after lymphocyte depletion: a key issue in clinical immunology

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Congenital Alopecia and nail dystrophy associated with severe functional T-cell immunodeficiency in two sibs

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Juvenile rheumatoid arthritis-like polyarthritis in chromosome 22q11.2 deletion syndrome (digeorge anomalad/velocardiofacial syndrome/conotruncal anomaly face syndrome)

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial deletions of chromosome 22q11

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial deletions of chromosome 22q11: the Leuven experience

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Congenital heart disease in mice deficient for the DiGeorge syndrome region

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IMMUNOLOGICAL FUNCTION OF THE THYMUS

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nail dystrophy associated with a heterozygous mutation of the nude/SCID human FOXN1 (WHN) gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-Natal Ontogenesis of the T-Cell Receptor CD4 and CD8 Vβ Repertoire and Immune Function in Children with DiGeorge Syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

B-cell recovery after stem cell transplantation of Artemis-deficient SCID requires elimination of autologous bone marrow precursor-B-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of Dll4 and CCL25 in Foxn1-negative epithelial cells in the post-natal thymus

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The aged thymus shows normal recruitment of lymphohematopoietic progenitors but has defects in thymic epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FOXN1 homozygous mutation associated with anencephaly and severe neural tube defect in human athymic Nude/SCID fetus

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Checkpoints in the development of thymic cortical epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FOXN1 mutation abrogates prenatal T-cell development in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Refractory autoimmune hemolytic anemia in a patient with chromosome 22q11.2 deletion syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

‘Nude’, a new hairless gene with pleiotropic effects in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrinsic defects of B cell function in X-linked severe combined immunodeficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multisystem involvement in congenital insensitivity to pain with anhidrosis (CIPA), a nerve growth factor receptor(Trk A)-related disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemokines define distinct microenvironments in the developing thymus

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human equivalent of the mouse Nude/SCID phenotype: long-term evaluation of immunologic reconstitution after bone marrow transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gcm2 and Foxn1 mark early parathyroid- and thymus-specific domains in the developing third pharyngeal pouch

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two distinct steps of immigration of hematopoietic progenitors into the early thymus anlage

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary immunodeficiency diseases: an update

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autoimmune cytopenias in the 22q11.2 deletion syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A domain of Foxn1 required for crosstalk-dependent thymic epithelial cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autoimmune phenomena in DiGeorge syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positional cloning of the nude locus: genetic, physical, and transcription maps of the region and mutations in the mouse and rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1155/2012/467101

1 reference

Europe PubMed Central

26 August 2017

release_gigpyv3utjc4bbdnznf6f57s3y

1 reference

https://api.fatcat.wiki/v0/release/gigpyv3utjc4bbdnznf6f57s3y

24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

26 August 2017

1 reference

Europe PubMed Central

26 August 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

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