(Q38012873)

27 August 2017

Cellular senescence: a double-edged sword in the fight against cancer (English)

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27 August 2017

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4

Eiji Hara

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27 August 2017

Naoko Ohtani

1

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27 August 2017

Akiko Takahashi

series ordinal

2

1 reference

27 August 2017

David J Mann

series ordinal

3

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27 August 2017

language of work or name

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1 July 2012

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27 August 2017

Experimental Dermatology

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27 August 2017

21 Suppl 1

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27 August 2017

1-4

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The outlook for population growth

27 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

The common biology of cancer and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Regulation of growth arrest in senescence: telomere damage is not the end of the story

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Cancer: crime and punishment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Senescence in tumours: evidence from mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

The essence of senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Four faces of cellular senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Putting the stress on senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Living on a break: cellular senescence as a DNA-damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

The retinoblastoma protein and the regulation of cell cycling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

The retinoblastoma tumour suppressor in development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Reversal of human cellular senescence: roles of the p53 and p16 pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Reinitiation of cellular DNA synthesis in BrdU-selected nondividing senescent WI-38 cells by simian virus 40 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Regulation of ploidy and senescence by the AMPK-related kinase NUAK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Feedback between p21 and reactive oxygen production is necessary for cell senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Oxidant signals and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

LATS tumor suppressor: a new governor of cellular homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Chemokine signaling via the CXCR2 receptor reinforces senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Senescence-messaging secretome: SMS-ing cellular stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Real-time in vivo imaging of p16Ink4a reveals cross talk with p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

The diverse functions of histone lysine methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

H3K9 methyltransferase G9a and the related molecule GLP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Restoration of p53 function leads to tumour regression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Senescence of activated stellate cells limits liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01493.X

10.1111/J.1600-0625.2012.01493.X

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference