(Q38018381)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22694351%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

title

Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation (English)

1 reference

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4 February 2020

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22694351%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

author name string

Timothy M Palmer

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22694351%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

language of work or name

English

0 references

publication date

14 June 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22694351%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Investigational Drugs

4 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22694351%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

volume

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22694351%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22694351%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

page(s)

1155-1167

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22694351%20AND%20SRC:MED&resulttype=core&format=json

Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site

4 February 2020

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21 January 2018

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21 January 2018

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Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta.

21 January 2018

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Molecular mechanisms of ghrelin-mediated endothelial nitric oxide synthase activation

21 January 2018

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Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

21 January 2018

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Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

21 January 2018

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Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

21 January 2018

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Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.

21 January 2018

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Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells

21 January 2018

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The selectivity of protein kinase inhibitors: a further update

21 January 2018

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Compound C independent of AMPK inhibits ICAM-1 and VCAM-1 expression in inflammatory stimulants-activated endothelial cells in vitro and in vivo.

21 January 2018

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Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

21 January 2018

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Actual status of antiinterleukin-1 therapies in rheumatic diseases

21 January 2018

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Targeting IL-6 in the treatment of inflammatory and autoimmune diseases

21 January 2018

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Targeting TNF for Treatment of Cancer and Autoimmunity

21 January 2018

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Overview of TNF superfamily: a chest full of potential therapeutic targets

21 January 2018

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Smac mimetics and TNFalpha: a dangerous liaison?

21 January 2018

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TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes

21 January 2018

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A tangled web of ubiquitin chains: breaking news in TNF-R1 signaling.

21 January 2018

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TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer

21 January 2018

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21 January 2018

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Control of NF-kappaB-dependent transcriptional responses by chromatin organization

21 January 2018

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NF-kappaB signals induce the expression of c-FLIP.

21 January 2018

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Signalling of toll-like receptors.

21 January 2018

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The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress.

21 January 2018

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Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

21 January 2018

1 reference

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Isoform-selective 5'-AMP-activated protein kinase-dependent preconditioning mechanisms to prevent postischemic leukocyte-endothelial cell adhesive interactions

21 January 2018

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5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates experimental autoimmune encephalomyelitis via modulation of endothelial-monocyte interaction.

21 January 2018

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Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury.

21 January 2018

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Novel anti-inflammatory action of 5-aminoimidazole-4-carboxamide ribonucleoside with protective effect in dextran sulfate sodium-induced acute and chronic colitis.

21 January 2018

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Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α.

21 January 2018

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Inhibition of inducible nitric-oxide synthase by activators of AMP-activated protein kinase: a new mechanism of action of insulin-sensitizing drugs

21 January 2018

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5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase.

21 January 2018

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AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells.

21 January 2018

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Adenosine monophosphate-activated protein kinase modulates the activated phenotype of hepatic stellate cells.

21 January 2018

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Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1

21 January 2018

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Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype

21 January 2018

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AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300.

21 January 2018

1 reference

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Nitric oxide-induced activation of the AMP-activated protein kinase α2 subunit attenuates IκB kinase activity and inflammatory responses in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Elevated NF-κB activation is conserved in human myocytes cultured from obese type 2 diabetic patients and attenuated by AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

AMPK and SIRT1: a long-standing partnership?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Functional interplay between acetylation and methylation of the RelA subunit of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

MAPKs and their relevance to arthritis and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Berberine suppresses proinflammatory responses through AMPK activation in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

α1AMP-activated protein kinase preserves endothelial function during chronic angiotensin II treatment by limiting Nox2 upregulation

21 January 2018

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Aspirin-induced AMP-activated protein kinase activation regulates the proliferation of vascular smooth muscle cells from spontaneously hypertensive rats

21 January 2018

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AMPKalpha1 regulates the antioxidant status of vascular endothelial cells

21 January 2018

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Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

NOS2 regulation of NF-kappaB by S-nitrosylation of p65.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Adiponectin activation of AMPK disrupts leptin-mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS-3)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Metformin ameliorates IL-6-induced hepatic insulin resistance via induction of orphan nuclear receptor small heterodimer partner (SHP) in mouse models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Inhibition of tumor necrosis factor alpha-stimulated monocyte adhesion to human aortic endothelial cells by AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Lymphocytes accelerate epithelial tight junction assembly: role of AMP-activated protein kinase (AMPK)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Roles of SIRT1 in the acute and restorative phases following induction of inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise

21 January 2018

1 reference

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Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase

21 January 2018

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Interleukin-6 attenuates insulin-mediated increases in endothelial cell signaling but augments skeletal muscle insulin action via differential effects on tumor necrosis factor-alpha expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8+ T-cell-induced cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes.

21 January 2018

1 reference

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The liver kinase B1 is a central regulator of T cell development, activation, and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis

21 January 2018

1 reference

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AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis

21 January 2018

1 reference

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Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

21 January 2018

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Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16

21 January 2018

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Immunity, Inflammation, and Cancer

21 January 2018

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Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

21 January 2018

1 reference

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Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Roles of AMP-activated protein kinase in diabetes-induced retinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

The ancient drug salicylate directly activates AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Clinical use of aspirin in treatment and prevention of cardiovascular disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.696609

mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Signal transducer and activator of transcription 3 is required for abnormal proliferation and survival of TSC2-deficient cells: relevance to pulmonary lymphangioleiomyomatosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

Shedding light on the intricate puzzle of ghrelin's effects on appetite regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609

5-Aminoimidazole-4-Carboxamide-1- -D-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase-Independent Effect on Glucokinase Translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.696609