(Q38029514)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22832870%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

Metallostasis and amyloid β-degrading enzymes (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22832870%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22832870%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Maria Laura Giuffrida

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22832870%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Enrico Rizzarelli

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22832870%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

author name string

Giuseppe Grasso

1

1 reference

27 August 2017

Maria Laura Giuffrida

2

1 reference

27 August 2017

Enrico Rizzarelli

3

1 reference

27 August 2017

1 August 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22832870%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22832870%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

volume

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22832870%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22832870%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

page(s)

937-949

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22832870%20AND%20SRC:MED&resulttype=core&format=json

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

9 February 2020

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Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease

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PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses

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GEPT extract reduces Abeta deposition by regulating the balance between production and degradation of Abeta in APPV717I transgenic mice

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Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

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The AbetaCs of Abeta-cleaving proteases

21 January 2018

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The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation

21 January 2018

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From presenilinase to gamma-secretase, cleave to capacitate

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Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease. Implications for the physiological function of HtrA2 in the mitochondria.

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Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease

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Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease?

21 January 2018

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Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

21 January 2018

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Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy

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21 January 2018

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21 January 2018

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Zinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluid

21 January 2018

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Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide

21 January 2018

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The molecular bases of Alzheimer's disease and other neurodegenerative disorders

21 January 2018

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Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron.

21 January 2018

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Mammalian zinc transporters: nutritional and physiologic regulation

21 January 2018

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Brain iron uptake and homeostatic mechanisms: an overview

21 January 2018

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Effect of a deficiency of ceruloplasmin copper in blood plasma on copper metabolism in the brain.

21 January 2018

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A potential role for zinc alterations in the pathogenesis of Alzheimer's disease

21 January 2018

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Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer's disease?

21 January 2018

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Genetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates aβ pathology in a Drosophila model of Alzheimer's disease

21 January 2018

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New evidence on iron, copper accumulation and zinc depletion and its correlation with DNA integrity in aging human brain regions

21 January 2018

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The distribution profile and oxidation states of biometals in APP transgenic mouse brain: dyshomeostasis with age and as a function of the development of Alzheimer's disease.

21 January 2018

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Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress.

21 January 2018

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Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

21 January 2018

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Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides.

21 January 2018

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Kinetic analysis of beta-amyloid peptide aggregation induced by metal ions based on surface plasmon resonance biosensing

21 January 2018

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Metal loading capacity of Abeta N-terminus: a combined potentiometric and spectroscopic study of zinc(II) complexes with Abeta(1-16), its short or mutated peptide fragments and its polyethylene glycol-ylated analogue

21 January 2018

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Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide

21 January 2018

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Affinity of Cu+ for the copper-binding domain of the amyloid-β peptide of Alzheimer's disease.

21 January 2018

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Beta-amyloid protein oligomers induced by metal ions and acid pH are distinct from those generated by slow spontaneous ageing at neutral pH.

21 January 2018

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The aggregated state of amyloid-beta peptide in vitro depends on Cu2+ ion concentration.

21 January 2018

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Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity

21 January 2018

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Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

21 January 2018

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NMR reveals anomalous copper(II) binding to the amyloid Abeta peptide of Alzheimer's disease.

21 January 2018

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Cu(2+) Inhibits the Aggregation of Amyloid beta-Peptide(1-42) in vitro We thank JEOL for the AFM measurement. This work was supported in part by Grants-in-Aid from the Japanese Ministry of Education, Science, Sports, and Culture, and a Grant from "R

21 January 2018

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New insights on how metals disrupt amyloid beta-aggregation and their effects on amyloid-beta cytotoxicity

21 January 2018

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Influence of multiple metal ions on beta-amyloid aggregation and dissociation on a solid surface.

21 January 2018

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High-throughput analysis of Alzheimer's beta-amyloid aggregation using a microfluidic self-assembly of monomers.

21 January 2018

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The second Cu(II)-binding site in a proton-rich environment interferes with the aggregation of amyloid-beta(1-40) into amyloid fibrils

21 January 2018

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Modulation of Abeta42 fibrillogenesis by glycosaminoglycan structure

21 January 2018

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Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation

21 January 2018

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Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ

21 January 2018

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Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo

21 January 2018

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Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.

21 January 2018

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Beta-amyloid monomers are neuroprotective.

21 January 2018

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Influence of divalent cations on the structural thermostability and thermal inactivation kinetics of class II xylose isomerases

21 January 2018

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Structural features of thermozymes

21 January 2018

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21 January 2018

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Iron binding effects on the kinetic stability and unfolding energetics of a thermophilic phenylalanine hydroxylase from Chloroflexus aurantiacus

21 January 2018

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Contributions of Zn(II)-binding to the structural stability of endostatin.

21 January 2018

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Metal ions bound at the active site of the junction-resolving enzyme T7 endonuclease I

21 January 2018

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Type II restriction endonucleases: structure and mechanism

21 January 2018

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Kinetic analysis of product release and metal ions in a metallonuclease

21 January 2018

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Metal complexes as enzyme inhibitors

21 January 2018

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Role of two active site Glu residues in the molecular action of botulinum neurotoxin endopeptidase

21 January 2018

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Zinc ion-induced domain organization in metallo-beta-lactamases: a flexible "zinc arm" for rapid metal ion transfer?

21 January 2018

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The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: importance of active site metal ions in the binding of substrates and inhibitors.

21 January 2018

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Characterization of the vaccinia virus D10 decapping enzyme provides evidence for a two-metal-ion mechanism

21 January 2018

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Bacillus D-stereospecific metallo-amidohydrolase: active-site metal-ion substitution changes substrate specificity

21 January 2018

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Binding and kinetic data for rabbit liver fructose-1,6-bisphosphatase with Zn 2+ as cofactor

21 January 2018

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Structural and functional implications of metal ion selection in aminopeptidase P, a metalloprotease with a dinuclear metal center.

21 January 2018

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Neprilysin and amyloid beta peptide degradation

21 January 2018

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Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme.

21 January 2018

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Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

21 January 2018

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Hyperinsulinemia and risk of Alzheimer disease.

21 January 2018

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Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

21 January 2018

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AP/MALDI-MS complete characterization of the proteolytic fragments produced by the interaction of insulin degrading enzyme with bovine insulin

21 January 2018

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Enzyme solid-state support assays: a surface plasmon resonance and mass spectrometry coupled study of immobilized insulin degrading enzyme

21 January 2018

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Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays.

21 January 2018

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Amyloidogenic determinant as a substrate recognition motif of insulin-degrading enzyme.

21 January 2018

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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

21 January 2018

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Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity

21 January 2018

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How the binding and degrading capabilities of insulin degrading enzyme are affected by ubiquitin

21 January 2018

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Copper(I) and copper(II) inhibit Aβ peptides proteolysis by insulin-degrading enzyme differently: implications for metallostasis alteration in Alzheimer's disease.

21 January 2018

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Metal ions affect insulin-degrading enzyme activity.

21 January 2018

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The insulysin (insulin degrading enzyme) enigma

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2MT20105D

Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2MT20105D

Overexpression of insulin degrading enzyme: cellular localization and effects on insulin signaling

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2MT20105D

Oxidative stress and cell membranes in the pathogenesis of Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2MT20105D

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease

21 January 2018

1 reference

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beta-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer's disease.

21 January 2018

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Poly-N-methylated amyloid beta-peptide (Abeta) C-terminal fragments reduce Abeta toxicity in vitro and in Drosophila melanogaster.

21 January 2018

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Abeta(31-35) peptide induce apoptosis in PC 12 cells: contrast with Abeta(25-35) peptide and examination of underlying mechanisms.

21 January 2018

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Targeted hydrolysis of Beta-amyloid with engineered antibody fragment

21 January 2018

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The proteolytic activity of insulin-degrading enzyme: a mass spectrometry study

21 January 2018

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Alzheimer's disease and metals: a review of the involvement of cellular membrane receptors in metallosignalling

21 January 2018

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Copper ions strongly activate the phosphoinositide-3-kinase/Akt pathway independent of the generation of reactive oxygen species

21 January 2018

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Effect of transition metals in synaptic damage induced by amyloid beta peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

The inorganic perspective of nerve growth factor: interactions of Cu2+ and Zn2+ with the N-terminus fragment of nerve growth factor encompassing the recognition domain of the TrkA receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Intracellular zinc fluctuations modulate protein tyrosine phosphatase activity in insulin/insulin-like growth factor-1 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Site-activated multifunctional chelator with acetylcholinesterase and neuroprotective-neurorestorative moieties for Alzheimer's therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Nanoparticle-chelator conjugates as inhibitors of amyloid-beta aggregation and neurotoxicity: a novel therapeutic approach for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Clioquinol inhibits peroxide-mediated toxicity through up-regulation of phosphoinositol-3-kinase and inhibition of p53 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Copper and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

New and evolving concepts in the neurotoxicology of lead

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

In vitro Pb exposure disturbs the balance between Aβ production and elimination: the role of AβPP and neprilysin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Oxidative stress signalling in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Calcium dyshomeostasis in white matter pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Neuronal calcium signaling, mitochondrial dysfunction, and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Intracellular calcium signalling in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Amyloid beta protein (1-40) forms calcium-permeable, Zn2+-sensitive channel in reconstituted lipid vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

In vivo reduction of amyloid-beta by a mutant copper transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Aluminum modulation of proteolytic activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Therapeutic strategies of Alzheimer's disease through manipulation of A? metabolism: a focus on A?-degrading peptidase, neprilysin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Investigations of the molecular mechanism of metal-induced Abeta (1-40) amyloidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D

Drug Development Based on the Metals Hypothesis of Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20105D