(Q37799838)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20942746%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

title

Novel drug targets based on metallobiology of Alzheimer's disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20942746%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

0 references

Sanghamitra Bandyopadhyay

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20942746%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Jack T Rogers

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20942746%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

author name string

Xudong Huang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20942746%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Debomoy K Lahiri

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20942746%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

language of work or name

English

0 references

publication date

1 November 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20942746%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Therapeutic Targets

15 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20942746%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

volume

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20942746%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20942746%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

page(s)

1177-1197

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20942746%20AND%20SRC:MED&resulttype=core&format=json

Current therapeutic targets for the treatment of Alzheimer's disease

15 February 2020

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Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD

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A potential pathogenetic role of iron in Alzheimer's disease.

21 January 2018

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Cytosolic aconitase and ferritin are regulated by iron in Caenorhabditis elegans

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Abnormal localization of iron regulatory protein in Alzheimer's disease.

21 January 2018

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Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences.

21 January 2018

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An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript

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Polymorphisms in the promoter of the human APP gene: functional evaluation and allele frequencies in Alzheimer disease.

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Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease brain tissue express melanotransferrin.

21 January 2018

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A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains.

21 January 2018

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Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia.

21 January 2018

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Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer's disease.

21 January 2018

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Iron genes, iron load and risk of Alzheimer's disease

21 January 2018

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Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

21 January 2018

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Ternary complexes of iron, amyloid-beta, and nitrilotriacetic acid: binding affinities, redox properties, and relevance to iron-induced oxidative stress in Alzheimer's disease

21 January 2018

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Redox cycling of iron by Abeta42.

21 January 2018

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Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress.

21 January 2018

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Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease

21 January 2018

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Down-regulation of aminolevulinate synthase, the rate-limiting enzyme for heme biosynthesis in Alzheimer's disease

21 January 2018

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Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias

21 January 2018

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A role for heme in Alzheimer's disease: heme binds amyloid beta and has altered metabolism

21 January 2018

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Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease

21 January 2018

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The role of iron in beta amyloid toxicity

21 January 2018

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Metal and inflammatory targets for Alzheimer's disease

21 January 2018

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Abeta[25-35] peptide and iron promote apoptosis in lymphocytes by an oxidative stress mechanism: involvement of H2O2, caspase-3, NF-kappaB, p53 and c-Jun.

21 January 2018

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Deposition of iron and beta-amyloid plaques is associated with cortical cellular damage in rabbits fed with long-term cholesterol-enriched diets.

21 January 2018

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Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level.

21 January 2018

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Redox-active iron mediates amyloid-beta toxicity

21 January 2018

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Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains

21 January 2018

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The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein

21 January 2018

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Characterization of Neutral Proteinases from Alzheimer-Affected and Control Brain Specimens: Identification of Calcium-Dependent Metalloproteinases from the Hippocampus

21 January 2018

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The neurobiology of zinc in health and disease

21 January 2018

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Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain

21 January 2018

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Rapid induction of Alzheimer A beta amyloid formation by zinc.

21 January 2018

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Zinc homeostasis in aging: two elusive faces of the same "metal".

21 January 2018

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Overview of mammalian zinc transporters

21 January 2018

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Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease.

21 January 2018

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Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

21 January 2018

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Zinc enhances synthesis of presenilin 1 in mouse primary cortical culture

21 January 2018

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Zinc metabolism in the brain: relevance to human neurodegenerative disorders

21 January 2018

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Drastic reduction of the zinc- and magnesium-stimulated protein tyrosine kinase activities in Alzheimer's disease hippocampus.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Zinc-amyloid beta interactions on a millisecond time-scale stabilize non-fibrillar Alzheimer-related species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.

21 January 2018

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High-resolution NMR studies of the zinc-binding site of the Alzheimer's amyloid beta-peptide.

21 January 2018

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Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide

21 January 2018

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NMR studies of the Zn2+ interactions with rat and human beta-amyloid (1-28) peptides in water-micelle environment.

21 January 2018

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Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging

21 January 2018

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Zinc binding to amyloid-beta: isothermal titration calorimetry and Zn competition experiments with Zn sensors.

21 January 2018

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Isomerization of the Asp7 residue results in zinc-induced oligomerization of Alzheimer's disease amyloid beta(1-16) peptide

21 January 2018

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Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-beta (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Mechanism of zinc(II)-promoted amyloid formation: zinc(II) binding facilitates the transition from the partially alpha-helical conformer to aggregates of amyloid beta protein(1-28).

21 January 2018

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Ceruloplasmin fragmentation is implicated in 'free' copper deregulation of Alzheimer's disease

21 January 2018

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Metals and amyloid-beta in Alzheimer's disease

21 January 2018

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Metallo-complex activation of neuroprotective signalling pathways as a therapeutic treatment for Alzheimer's disease

21 January 2018

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Abeta-mediated ROS production by Cu ions: structural insights, mechanisms and relevance to Alzheimer's disease.

21 January 2018

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Copper in the brain and Alzheimer's disease

21 January 2018

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Alzheimer disease and the role of free radicals in the pathogenesis of the disease

21 January 2018

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Longitudinal prognostic value of serum "free" copper in patients with Alzheimer disease.

21 January 2018

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Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment

21 January 2018

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Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

21 January 2018

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Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Hydrogen peroxide mediates amyloid beta protein toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Cholesterol, copper and Abeta in controls, MCI, AD and the AD cholesterol-lowering treatment trial (ADCLT).

21 January 2018

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Lipid peroxidation and 4-hydroxy-2-nonenal formation by copper ion bound to amyloid-beta peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Amyloid beta-Cu2+ complexes in both monomeric and fibrillar forms do not generate H2O2 catalytically but quench hydroxyl radicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

The beta A4 amyloid precursor protein binding to copper.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Copper binding to the Alzheimer's disease amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

A copper-binding site in the cytoplasmic domain of BACE1 identifies a possible link to metal homoeostasis and oxidative stress in Alzheimer's disease.

21 January 2018

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Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene

21 January 2018

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Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

21 January 2018

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N-Terminal deletions modify the Cu2+ binding site in amyloid-beta

21 January 2018

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The Cu(II)/Abeta/human serum albumin model of control mechanism for copper-related amyloid neurotoxicity.

21 January 2018

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The chemistry of Alzheimer's disease

21 January 2018

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Direct evidence that all three histidine residues coordinate to Cu(II) in amyloid-beta1-16.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Pleomorphic copper coordination by Alzheimer's disease amyloid-beta peptide

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Alanine-2 carbonyl is an oxygen ligand in Cu2+ coordination of Alzheimer's disease amyloid-beta peptide--relevance to N-terminally truncated forms.

21 January 2018

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The amyloid-beta peptide of Alzheimer's disease binds Cu(I) in a linear bis-his coordination environment: insight into a possible neuroprotective mechanism for the amyloid-beta peptide

21 January 2018

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Importance of dynamical processes in the coordination chemistry and redox conversion of copper amyloid-beta complexes.

21 January 2018

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Structural studies of copper(I) complexes of amyloid-beta peptide fragments: formation of two-coordinate bis(histidine) complexes

21 January 2018

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Catechol oxidase-like oxidation chemistry of the 1-20 and 1-16 fragments of Alzheimer's disease-related beta-amyloid peptide: their structure-activity correlation and the fate of hydrogen peroxide

21 January 2018

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Copper binding to the amyloid-beta (Abeta) peptide associated with Alzheimer's disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta-(1-28): insights from a range of complementary spectroscopic techniques

21 January 2018

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Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Three histidine residues of amyloid-beta peptide control the redox activity of copper and iron

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Binding of zinc(II) and copper(II) to the full-length Alzheimer's amyloid-beta peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Mounting evidence for the involvement of zinc and copper in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Aluminum forms in drinking water and risk of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Aluminium, Alzheimer's disease, and drinking water

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Aluminum and silica in drinking water and the risk of Alzheimer's disease or cognitive decline: findings from 15-year follow-up of the PAQUID cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Neurotoxic effects of aluminium among foundry workers and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Demonstration of aluminum in amyloid fibers in the cores of senile plaques in the brains of patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

First evidence for helical transitions in supercoiled DNA by amyloid Beta Peptide (1-42) and aluminum: a new insight in understanding Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Effects of oral aluminum exposure on behavior and neurogenesis in a transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Aluminum modulates effects of beta amyloid(1-42) on neuronal calcium homeostasis and mitochondria functioning and is altered in a triple transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Aluminum in hippocampal neurons from humans with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Aluminium accumulation in relation to senile plaque and neurofibrillary tangle formation in the brains of patients with renal failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Potentiation of beta-folding of beta-amyloid peptide 25-35 by aluminum salts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

The solubilization of model Alzheimer tangles: reversing the beta-sheet conformation induced by aluminum with silicates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Clioquinol, a drug for Alzheimer's disease specifically interfering with brain metal metabolism: structural characterization of its zinc(II) and copper(II) complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Metal ion-dependent effects of clioquinol on the fibril growth of an amyloid {beta} peptide

21 January 2018

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

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Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Metal complexing agents as therapies for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

The metallobiology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Design, selection, and characterization of thioflavin-based intercalation compounds with metal chelating properties for application in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human beta-amyloid precursor protein transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

A new strategy to combat Alzheimer's disease. Combining radical-scavenging potential with metal-protein-attenuating ability in one molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Physiological and pathological aspects of Abeta in iron homeostasis via 5'UTR in the APP mRNA and the therapeutic use of iron-chelators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Changes in uptake of vitamin B(12) and trace metals in brains of mice treated with clioquinol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Current status of metals as therapeutic targets in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Intramuscular desferrioxamine in patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Therapeutic targets and potential of the novel brain- permeable multifunctional iron chelator-monoamine oxidase inhibitor drug, M-30, for the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Up-regulation of hypoxia-inducible factor (HIF)-1α and HIF-target genes in cortical neurons by the novel multifunctional iron chelator anti-Alzheimer drug, M30.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Rasagiline: neurodegeneration, neuroprotection, and mitochondrial permeability transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Glycosylated tetrahydrosalens as multifunctional molecules for Alzheimer's therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Synthesis, characterization, and metal coordinating ability of multifunctional carbohydrate-containing compounds for Alzheimer's therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

In vitro studies of 3-hydroxy-4-pyridinones and their glycosylated derivatives as potential agents for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Combating Alzheimer's disease with multifunctional molecules designed for metal passivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Multi-target-directed ligands to combat neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Sequestration of copper from beta-amyloid promotes selective lysis by cyclen-hybrid cleavage agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Tetrahydroaminoacridine (THA) as a pharmacological probe in Alzheimer's disease (AD) and other neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

A novel trivalent cation chelator Feralex dissociates binding of aluminum and iron associated with hyperphosphorylated tau of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Aluminum-induced oxidative stress in rat brain: response to combined administration of citric acid and HEDTA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Nanoparticle-chelator conjugates as inhibitors of amyloid-beta aggregation and neurotoxicity: a novel therapeutic approach for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Nanoparticle iron chelators: a new therapeutic approach in Alzheimer disease and other neurologic disorders associated with trace metal imbalance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Nanoparticle and other metal chelation therapeutics in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Nanoparticle and iron chelators as a potential novel Alzheimer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Stability and structure of binary and ternary complexes of α-lipoate and lipoate derivatives with Mn2+, Cu2+, and Zn2+ in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Lipoic acid: a novel therapeutic approach for multiple sclerosis and other chronic inflammatory diseases of the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Benefits from dietary polyphenols for brain aging and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

The redox chemistry of the Alzheimer's disease amyloid beta peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Amount and type of alcohol and risk of dementia: the Copenhagen City Heart Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Gossypin protects primary cultured rat cortical cells from oxidative stress- and beta-amyloid-induced toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Melatonin and 6-hydroxymelatonin protect against iron-induced neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Elevation of serum copper levels in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

d-penicillamine reduces serum oxidative stress in Alzheimer's disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Copper toxicity in the general population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Anti-copper therapies in Alzheimer's disease: new concepts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Targeting multiple Alzheimer's disease etiologies with multimodal neuroprotective and neurorestorative iron chelators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

FDA-preapproved drugs targeted to the translational regulation and processing of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Anticholinesterase and pharmacokinetic profile of phenserine in healthy elderly human subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

A high-throughput drug screen targeted to the 5'untranslated region of Alzheimer amyloid precursor protein mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Role of the APP non-amyloidogenic signaling pathway and targeting alpha-secretase as an alternative drug target for treatment of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Interleukin-1alpha stimulates non-amyloidogenic pathway by alpha-secretase (ADAM-10 and ADAM-17) cleavage of APP in human astrocytic cells involving p38 MAP kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

S100A7, a novel Alzheimer's disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Regulating amyloid precursor protein synthesis through an internal ribosomal entry site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Amyloid-β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Zinc Binding to Alzheimer's Aβ(1–16) Peptide Results in Stable Soluble Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525352

Alzheimer's disease, beta-amyloid protein and zinc

21 January 2018

1 reference

12 December 2020

Alterations in the interaction between iron regulatory proteins and their iron responsive element in normal and Alzheimer's diseased brains.

1 reference

12 December 2020

Metal chelation as a potential therapy for Alzheimer's disease.

1 reference

12 December 2020

S100beta interaction with tau is promoted by zinc and inhibited by hyperphosphorylation in Alzheimer's disease

1 reference

12 December 2020

The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse.

1 reference

12 December 2020

Aluminum modulates brain amyloidosis through oxidative stress in APP transgenic mice

1 reference

12 December 2020

Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease.

1 reference

12 December 2020

The degradation of Abeta(25-35) by the serine protease plasmin is inhibited by aluminium.

1 reference

12 December 2020

Protection against amyloid beta peptide and iron/hydrogen peroxide toxicity by alpha lipoic acid

1 reference

12 December 2020

Characterization of high affinity binding between laminin and Alzheimer's disease amyloid precursor proteins.

1 reference

12 December 2020

Aluminium, iron, zinc and copper influence the in vitro formation of amyloid fibrils of Abeta42 in a manner which may have consequences for metal chelation therapy in Alzheimer's disease.

1 reference

12 December 2020

Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease

1 reference

12 December 2020

Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid

1 reference

12 December 2020

Amyloid-beta binds Cu2+ in a mononuclear metal ion binding site

1 reference

12 December 2020

Characterization of the APP proximal promoter and 5'-untranslated regions: identification of cell type-specific domains and implications in APP gene expression and Alzheimer's disease.

1 reference

12 December 2020

Is zinc the link between compromises of brain perfusion (excitotoxicity) and Alzheimer's disease?

1 reference

12 December 2020

Aluminium and iron, but neither copper nor zinc, are key to the precipitation of beta-sheets of Abeta_{42} in senile plaque cores in Alzheimer's disease.

1 reference

12 December 2020

Aluminum and other metals in Alzheimer's disease: a review of potential therapy with chelating agents.

1 reference

12 December 2020

Metal specificity of an iron-responsive element in Alzheimer's APP mRNA 5'untranslated region, tolerance of SH-SY5Y and H4 neural cells to desferrioxamine, clioquinol, VK-28, and a piperazine chelator.

1 reference

12 December 2020

Aluminium exposure induces Alzheimer's disease-like histopathological alterations in mouse brain

1 reference

12 December 2020

Metal protein attenuating compounds for the treatment of Alzheimer's disease

1 reference

12 December 2020

Altered expression and distribution of zinc transporters in APP/PS1 transgenic mouse brain

1 reference

12 December 2020

An observational study on the influence of the APOE-ε4 allele on the correlation between ‘free’ copper toxicosis and EEG activity in Alzheimer disease

1 reference

12 December 2020

Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer's plaque core material

1 reference

12 December 2020

The use of copper-lowering therapy with tetrathiomolybdate in medicine

1 reference

12 December 2020

Suppression of glial HO-1 activity as a potential neurotherapeutic intervention in AD.

1 reference

12 December 2020

Pulse EPR spectroscopy reveals the coordination sphere of copper(II) ions in the 1-16 amyloid-beta peptide: a key role of the first two N-terminus residues

1 reference

12 December 2020

Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1.

1 reference

12 December 2020

Treatment of Wilson's disease with zinc. II. Validation of oral 64copper with copper balance

1 reference

12 December 2020

Cholinergic denervation-induced increase of chelatable zinc in mossy-fiber region of the hippocampal formation

1 reference

12 December 2020

Alzheimer's disease: X-ray spectrometric evidence of aluminum accumulation in neurofibrillary tangle-bearing neurons

1 reference

12 December 2020

Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant?

1 reference

12 December 2020

Iron levels modulate alpha-secretase cleavage of amyloid precursor protein

1 reference

12 December 2020

The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily

1 reference

12 December 2020

Modulation of A beta adhesiveness and secretase site cleavage by zinc.

1 reference

12 December 2020

Non-amyloidogenic cleavage of the beta-amyloid precursor protein by an integral membrane metalloendopeptidase

1 reference

12 December 2020

A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease

1 reference

12 December 2020

Characterization of the high affinity heparin binding site of the Alzheimer's disease beta A4 amyloid precursor protein (APP) and its enhancement by zinc(II)

1 reference

12 December 2020

Cellular phosphorylation of tau by GSK-3 beta influences tau binding to microtubules and microtubule organisation

1 reference

12 December 2020

Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area

1 reference

12 December 2020

Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress.

1 reference

12 December 2020

Molecular mechanisms of cellular injury produced by neurotoxic amino acids that generate reactive oxygen species

1 reference

12 December 2020

10.1517/14728222.2010.525352

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20942746%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20942746%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

PubMed publication ID

20942746

1 reference