(Q38059380)

28 August 2017

title

New approaches in antimalarial drug discovery and development: a review (English)

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28 August 2017

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5

Antoniana U Krettli

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28 August 2017

author name string

Anna Caroline C Aguiar

1

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28 August 2017

Eliana M M da Rocha

2

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28 August 2017

Nicolli B de Souza

3

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28 August 2017

Tanos C C França

4

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28 August 2017

publication date

1 November 2012

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Memórias do Instituto Oswaldo Cruz

28 August 2017

number of pages

15

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based on heuristic

inferred from page(s)

published in

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28 August 2017

volume

107

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28 August 2017

issue

7

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28 August 2017

page(s)

831-845

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ICM?A new method for protein modeling and design: Applications to docking and structure prediction from the distorted native conformation

28 August 2017

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21 January 2018

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Ampelozyziphus amazonicus Ducke (Rhamnaceae), a medicinal plant used to prevent malaria in the Amazon Region, hampers the development of Plasmodium berghei sporozoites.

21 January 2018

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Antimalarial activity of Bidens pilosa L. (Asteraceae) ethanol extracts from wild plants collected in various localities or plants cultivated in humus soil.

21 January 2018

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Current status of Plasmodium vivax vaccine.

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Genetic diversity of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) and its effect on the performance of PfHRP2-based rapid diagnostic tests

21 January 2018

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Antimalarial pharmacodynamics of chalcone derivatives in combination with artemisinin against Plasmodium falciparum in vitro.

21 January 2018

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Plasmodium falciparum apicoplast drugs: targets or off-targets?

21 January 2018

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The state of the art in anti-malarial drug discovery and development

21 January 2018

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Challenges in antimalarial drug discovery

21 January 2018

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A plant-derived morphinan as a novel lead compound active against malaria liver stages

21 January 2018

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Antimalarial chemotherapy with natural products and chemically defined molecules

21 January 2018

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Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

21 January 2018

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Validating a firefly luciferase-based high-throughput screening assay for antimalarial drug discovery

21 January 2018

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Human malarial disease: a consequence of inflammatory cytokine release

21 January 2018

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From the circumsporozoite protein to the RTS, S/AS candidate vaccine

21 January 2018

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Knowlesi malaria: newly emergent and of public health importance?

21 January 2018

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Synthesis, antimalarial activity, and intracellular targets of MEFAS, a new hybrid compound derived from mefloquine and artesunate

21 January 2018

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4-aminoquinoline analogues and its platinum (II) complexes as antimalarial agents

21 January 2018

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Synthesis of ferroquine enantiomers: first investigation of effects of metallocenic chirality upon antimalarial activity and cytotoxicity.

21 January 2018

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Homology modeling of the estrogen receptor subtype beta (ER-beta) and calculation of ligand binding affinities

21 January 2018

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Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

21 January 2018

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A green fluorescent protein-based assay for determining gametocyte production in Plasmodium falciparum

21 January 2018

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Artemisinin Resistance in Plasmodium falciparum Malaria

21 January 2018

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Malarial haemozoin/beta-haematin supports haem polymerization in the absence of protein

21 January 2018

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Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach

21 January 2018

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Development and optimization of a novel 384-well anti-malarial imaging assay validated for high-throughput screening

21 January 2018

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A three-dimensional structure of Plasmodium falciparum serine hydroxymethyltransferase in complex with glycine and 5-formyl-tetrahydrofolate. Homology modeling and molecular dynamics.

21 January 2018

1 reference

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Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria

21 January 2018

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https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Malaria: progress, perils, and prospects for eradication

21 January 2018

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Algae-produced Pfs25 elicits antibodies that inhibit malaria transmission

21 January 2018

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Monitoring Plasmodium falciparum growth and development by UV flow cytometry using an optimized Hoechst-thiazole orange staining strategy.

21 January 2018

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Development of the malaria parasite in the skin of the mammalian host

21 January 2018

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Plasmodium gallinaceum: avian screen for drugs with radical curative properties

21 January 2018

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An update on the search for a Plasmodium vivax vaccine

21 January 2018

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4-aminoquinolines active against chloroquine-resistant Plasmodium falciparum: basis of antiparasite activity and quantitative structure-activity relationship analyses

21 January 2018

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Engineered resistance to Plasmodium falciparum development in transgenic Anopheles stephensi

21 January 2018

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Plasmodium falciparum: development and validation of a measure of intraerythrocytic growth using SYBR Green I in a flow cytometer

21 January 2018

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Identification of Plasmodium falciparum spermidine synthase active site binders through structure-based virtual screening

21 January 2018

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Quantitative measurement of Plasmodium-infected erythrocytes in murine models of malaria by flow cytometry using bidimensional assessment of SYTO-16 fluorescence

21 January 2018

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Vector control: a cornerstone in the malaria elimination campaign

21 January 2018

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Discovery of dual function acridones as a new antimalarial chemotype

21 January 2018

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Structure-based design of novel small-molecule inhibitors of Plasmodium falciparum

21 January 2018

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Potential chemotherapeutic targets in the purine metabolism of parasites

21 January 2018

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Recent developments in the design and synthesis of hybrid molecules based on aminoquinoline ring and their antiplasmodial evaluation.

21 January 2018

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Antimalarial drug discovery: screening of Brazilian medicinal plants and purified compounds

21 January 2018

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Testing of natural products and synthetic molecules aiming at new antimalarials.

21 January 2018

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Safety and tolerability of elubaquine (bulaquine, CDRI 80/53) for treatment of Plasmidium vivax malaria in Thailand

21 January 2018

1 reference

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Clindamycin as an antimalarial drug: review of clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2'O)-methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

A pre-emptive strike against malaria's stealthy hepatic forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

A phase 1 trial of MSP2-C1, a blood-stage malaria vaccine containing 2 isoforms of MSP2 formulated with Montanide® ISA 720

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

The proteases and pathogenicity of parasitic protozoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Comparative study of the efficacy and tolerability of dihydroartemisinin-piperaquine-trimethoprim versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Plasmodium falciparum falcilysin: a metalloprotease with dual specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

A colorimetric high-throughput beta-hematin inhibition screening assay for use in the search for antimalarial compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Natural products as sources of new drugs over the last 25 years

21 January 2018

1 reference

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Discovery of novel inhibitors targeting enoyl-acyl carrier protein reductase in Plasmodium falciparum by structure-based virtual screening

21 January 2018

1 reference

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Plasmodium falciparum: effect of anti-malarial drugs on the production and secretion characteristics of histidine-rich protein II.

21 January 2018

1 reference

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In vitro activity of antiretroviral drugs against Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Clindamycin plus quinine for treating uncomplicated falciparum malaria: a systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Standardization of the physicochemical parameters to assess in vitro the beta-hematin inhibitory activity of antimalarial drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Antimalarial effects of human immunodeficiency virus type 1 protease inhibitors differ from those of the aspartic protease inhibitor pepstatin

21 January 2018

1 reference

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Antimalarial asexual stage-specific and gametocytocidal activities of HIV protease inhibitors

21 January 2018

1 reference

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Anti-malarial drugs: how effective are they against Plasmodium falciparum gametocytes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Antimalarial activity of potential inhibitors of Plasmodium falciparum lactate dehydrogenase enzyme selected by docking studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Severe malarial anemia: innate immunity and pathogenesis

21 January 2018

1 reference

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New developments in Plasmodium vivax malaria: severe disease and the rise of chloroquine resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

An improved and highly sensitive microfluorimetric method for assessing susceptibility of Plasmodium falciparum to antimalarial drugs in vitro

21 January 2018

1 reference

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Medical need, scientific opportunity and the drive for antimalarial drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Expression of a mutated phospholipase A2 in transgenic Aedes fluviatilis mosquitoes impacts Plasmodium gallinaceum development

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Spiroindolones, a potent compound class for the treatment of malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Antimalarial activity of physalins B, D, F, and G.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Plasmodium berghei parasite transformed with green fluorescent protein for screening blood schizontocidal agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Validation of a Plasmodium falciparum parasite transformed with green fluorescent protein for antimalarial drug screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Immunological processes in malaria pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

A review of malaria vaccine clinical projects based on the WHO rainbow table

21 January 2018

1 reference

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Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Flow cytometric enumeration of Plasmodium berghei-infected red blood cells stained with SYBR Green I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Relapse of imported Plasmodium vivax malaria is related to primaquine dose: a retrospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum malaria: a randomised non-inferiority trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Fosmidomycin for the treatment of malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

In vitro and in vivo synergy of fosmidomycin, a novel antimalarial drug, with clindamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Improved traditional phytomedicines in current use for the clinical treatment of malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Development of fluorescent Plasmodium falciparum for in vitro growth inhibition assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Potential antimalarial lead structures from fungi of marine origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762012000700001

Imidazolopiperazines: hit to lead optimization of new antimalarial agents.

21 January 2018

1 reference

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10.1590/S0074-02762012000700001

21 January 2018

Identifiers

DOI

1 reference

28 August 2017

1 reference