(Q38061861)

28 August 2017

1 reference

title

A review of the role of Puma, Noxa and Bim in the tumorigenesis, therapy and drug resistance of chronic lymphocytic leukemia (English)

1 reference

28 August 2017

0 references

L-N Zhang

1

1 reference

28 August 2017

J-Y Li

series ordinal

2

1 reference

28 August 2017

W Xu

series ordinal

3

1 reference

28 August 2017

publication date

23 November 2012

1 reference

28 August 2017

1 reference

28 August 2017

volume

20

1 reference

28 August 2017

issue

1

1 reference

28 August 2017

page(s)

1-7

1 reference

B-cell chronic lymphocytic leukemia: a bird of a different feather

28 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

The role of BH3-only proteins in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

BH3-Only proteins-essential initiators of apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

PUMA, a novel proapoptotic gene, is induced by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Identification of a network involved in thapsigargin-induced apoptosis using a library of small interfering RNA expression vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

PUMA- and Bax-induced autophagy contributes to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

E1A activates transcription of p73 and Noxa to induce apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Therapeutic potential of proapoptotic molecule Noxa in the selective elimination of tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Bim is a suppressor of Myc-induced mouse B cell leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Prognostic impact of bim, puma, and noxa expression in human colon carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Different contribution of BH3-only proteins and caspases to doxorubicin-induced apoptosis in p53-deficient leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Histone deacetylases and cancer: causes and therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Histone deacetylase inhibitors: insights into mechanisms of lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Apoptosis induced by histone deacetylase inhibitors in leukemic cells is mediated by Bim and Noxa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Microarray analysis uncovers the induction of the proapoptotic BH3-only protein Bim in multiple models of glucocorticoid-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Inhibition of glucocorticoid-induced apoptosis by targeting the major splice variants of BIM mRNA with small interfering RNA and short hairpin RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Dexamethasone resistance in B-cell precursor childhood acute lymphoblastic leukemia occurs downstream of ligand-induced nuclear translocation of the glucocorticoid receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL, (-)-Gossypol, enhances biological effect of genistein against BxPC-3 human pancreatic cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

A small molecule pan-Bcl-2 family inhibitor, GX15-070, induces apoptosis and enhances cisplatin-induced apoptosis in non-small cell lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Phase I dose finding studies of obatoclax (GX15-070), a small molecule pan-BCL-2 family antagonist, in patients with advanced solid tumors or lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Apoptosis of B-cell chronic lymphocytic leukemia cells induced by a novel BH3 peptidomimetic

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

A novel Bim-BH3-derived Bcl-XL inhibitor: biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Preclinical studies of TW-37, a new nonpeptidic small-molecule inhibitor of Bcl-2, in diffuse large cell lymphoma xenograft model reveal drug action on both Bcl-2 and Mcl-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

TW-37, a small-molecule inhibitor of Bcl-2, mediates S-phase cell cycle arrest and suppresses head and neck tumor angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

The BH3-only mimetic ABT-737 synergizes the antineoplastic activity of proteasome inhibitors in lymphoid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Investigations on gossypol: past and present developments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Paraneoplastic leukemoid reaction and rapid progression in a patient with malignant melanoma: establishment of KT293, a novel G-CSF-secreting melanoma cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

ROS-mediated upregulation of Noxa overcomes chemoresistance in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Ad-PUMA sensitizes drug-resistant choriocarcinoma cells to chemotherapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Tipping the Noxa/Mcl-1 balance overcomes ABT-737 resistance in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

Regulation of the proapoptotic BH3-only protein BIM by glucocorticoids, survival signals and proteasome in chronic lymphocytic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

7 January 2021

(-)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

7 January 2021

p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

7 January 2021

PUMA expression is significantly reduced in human cutaneous melanomas

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

7 January 2021

Development of Noxa-like BH3 mimetics for apoptosis-based therapeutic strategy in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2012.84

7 January 2021

https://api.fatcat.wiki/v0/release/t5cit5nbhbd43gs4nhkv3ikcxi

Identifiers

1 reference

30 July 2022

mapped directly with Wikidata item

Fatcat ID

release_t5cit5nbhbd43gs4nhkv3ikcxi

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/t5cit5nbhbd43gs4nhkv3ikcxi

30 July 2022

mapped directly with Wikidata item

https://api.fatcat.wiki/v0/release/t5cit5nbhbd43gs4nhkv3ikcxi

1 reference

30 July 2022