(Q38063940)

28 August 2017

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title

Immunological pathways to β-cell damage in Type 1 diabetes (English)

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28 August 2017

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M Peakman

1

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publication date

1 February 2013

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28 August 2017

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28 August 2017

volume

30

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28 August 2017

issue

2

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28 August 2017

page(s)

147-154

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The multiple origins of Type 1 diabetes

28 August 2017

cites work

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Functional specialization of islet dendritic cell subsets

21 January 2018

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Analysis of islet inflammation in human type 1 diabetes.

21 January 2018

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Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

21 January 2018

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Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death

21 January 2018

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Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppression

21 January 2018

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Foxp3+ T cells induce perforin-dependent dendritic cell death in tumor-draining lymph nodes

21 January 2018

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Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.

21 January 2018

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Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.

21 January 2018

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Clues to immune tolerance: the monogenic autoimmune syndromes

21 January 2018

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Projection of an immunological self shadow within the thymus by the aire protein

21 January 2018

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Administration of CD4+CD25highCD127- regulatory T cells preserves β-cell function in type 1 diabetes in children

21 January 2018

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In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes

21 January 2018

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Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function

21 January 2018

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The environment and the origins of islet autoimmunity and Type 1 diabetes

21 January 2018

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Rituximab selectively suppresses specific islet antibodies

21 January 2018

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Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society

21 January 2018

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Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes

21 January 2018

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Immunology in the Clinic Review Series; focus on metabolic diseases: development of islet autoimmune disease in type 2 diabetes patients: potential sequelae of chronic inflammation

21 January 2018

1 reference

CD8 T cell autoreactivity to preproinsulin epitopes with very low human leucocyte antigen class I binding affinity.

21 January 2018

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Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes

21 January 2018

1 reference

Antigen targets of type 1 diabetes autoimmunity

21 January 2018

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Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4.

21 January 2018

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Gene expression profiles for the human pancreas and purified islets in type 1 diabetes: new findings at clinical onset and in long-standing diabetes.

21 January 2018

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Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.

21 January 2018

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IL-17 immunity in human type 1 diabetes

21 January 2018

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Blockade of interleukin 1 in type 1 diabetes mellitus

21 January 2018

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Primary and secondary prevention of Type 1 diabetes

21 January 2018

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Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers.

21 January 2018

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Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill β-cells

21 January 2018

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Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

21 January 2018

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Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes

21 January 2018

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A single autoimmune T cell receptor recognizes more than a million different peptides

21 January 2018

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Differential processing of self-antigens by subsets of thymic stromal cells.

21 January 2018

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How thymic antigen presenting cells sample the body's self-antigens

21 January 2018

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Delivering the kiss of death: progress on understanding how perforin works

21 January 2018

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The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal

21 January 2018

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Incidental CD8 T cell reactivity against caspase-cleaved apoptotic self-antigens from ubiquitously expressed proteins in islets from prediabetic human leucocyte antigen-A2 transgenic non-obese diabetic mice

21 January 2018

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Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice

21 January 2018

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The role of perforin and granzymes in diabetes.

21 January 2018

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Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes

21 January 2018

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Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.

21 January 2018

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CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

21 January 2018

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Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.

21 January 2018

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Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

21 January 2018

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Immunology in the clinic review series; focus on type 1 diabetes and viruses: role of antibodies enhancing the infection with Coxsackievirus-B in the pathogenesis of type 1 diabetes

21 January 2018

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Immunology in the clinic review series; focus on type 1 diabetes and viruses: enterovirus, thymus and type 1 diabetes pathogenesis

21 January 2018

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Immunology in the clinic review series; focus on type 1 diabetes and viruses: the innate immune response to enteroviruses and its possible role in regulating type 1 diabetes.

21 January 2018

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Immunology in the clinic review series; focus on type 1 diabetes and viruses: how viral infections modulate beta cell function

21 January 2018

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Immunology in the clinic review series; focus on type 1 diabetes and viruses: the enterovirus link to type 1 diabetes: critical review of human studies

21 January 2018

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Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma

21 January 2018

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Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

21 January 2018

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Viruses and type 1 diabetes: ignorance acquires a better vocabulary

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/DME.12085

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28 August 2017

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