(Q38065993)

28 August 2017

1 reference

title

Functional diversity and pharmacological profiles of the FKBPs and their complexes with small natural ligands (English)

1 reference

28 August 2017

1 reference

Andrzej Galat

1

1 reference

28 August 2017

publication date

8 December 2012

1 reference

Cellular and Molecular Life Sciences

28 August 2017

published in

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28 August 2017

volume

70

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28 August 2017

issue

18

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28 August 2017

page(s)

3243-3275

1 reference

https://scigraph.springernature.com/pub.10.1007/s00018-012-1206-z

28 August 2017

exact match

0 references

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Energetic and structural analysis of the role of tryptophan 59 in FKBP12

21 January 2018

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Chlamydia trachomatis Mip-like protein has peptidyl-prolyl cis/trans isomerase activity that is inhibited by FK506 and rapamycin and is implicated in initiation of chlamydial infection

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

21 January 2018

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The Trichoplax genome and the nature of placozoans

21 January 2018

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21 January 2018

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21 January 2018

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The Draft Genome of Ciona intestinalis: Insights into Chordate and Vertebrate Origins

21 January 2018

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The amphioxus genome and the evolution of the chordate karyotype

21 January 2018

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The genome of the sea urchin Strongylocentrotus purpuratus

21 January 2018

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Genome-scale approaches to resolving incongruence in molecular phylogenies

21 January 2018

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WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics

21 January 2018

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Sequence diversification of the FK506-binding proteins in several different genomes

21 January 2018

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Molecular aspects of cyclophilins mediating therapeutic actions of their ligands

21 January 2018

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Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires.

21 January 2018

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Cloning, expression and characterisation of FKB-6, the sole large TPR-containing immunophilin from C. elegans.

21 January 2018

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FKBP133: a novel mouse FK506-binding protein homolog alters growth cone morphology

21 January 2018

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A nuclear FK506-binding protein is a histone chaperone regulating rDNA silencing

21 January 2018

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Proline isomerization of histone H3 regulates lysine methylation and gene expression

21 January 2018

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Fpr3 and Zip3 ensure that initiation of meiotic recombination precedes chromosome synapsis in budding yeast

21 January 2018

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The FK506 binding protein Fpr3 counteracts protein phosphatase 1 to maintain meiotic recombination checkpoint activity

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

The yeast HtrA orthologue Ynm3 is a protease with chaperone activity that aids survival under heat stress

21 January 2018

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Molecular cloning and expression pattern of the Fkbp25 gene during cerebral cortical neurogenesis

21 January 2018

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Hydrophobicity scales and computational techniques for detecting amphipathic structures in proteins

21 January 2018

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Tetratricopeptide repeat cochaperones in steroid receptor complexes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

On transversal hydrophobicity of some proteins and their modules.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Involvement of some large immunophilins and their ligands in the protection and regeneration of neurons: a hypothetical mode of action

21 January 2018

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Association of immunophilins with mammalian TRPC channels

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

The immunophilin FKBP52 inhibits the activity of the epithelial Ca2+ channel TRPV5.

21 January 2018

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Two structures of cyclophilin 40: folding and fidelity in the TPR domains

21 January 2018

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Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

21 January 2018

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Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

21 January 2018

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Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

21 January 2018

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Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12

21 January 2018

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3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Common structural traits for cystine knot domain of the TGFβ superfamily of proteins and three-fingered ectodomain of their cellular receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Allosteric regulation and catalysis emerge via a common route.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

The origin of protein interactions and allostery in colocalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Graft-versus-host disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Stem cell niche: structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Structure of NFAT bound to DNA as a monomer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

NFAT signaling and the invention of vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Genome-wide screening for genes associated with FK506 sensitivity in fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Regulation of leucine uptake by tor1+ in Schizosaccharomyces pombe is sensitive to rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

FKBP12 binds to acylated H-ras and promotes depalmitoylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

FKBP12.6-knockout mice display hyperinsulinemia and resistance to high-fat diet-induced hyperglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

FKBP12.6 disruption impairs glucose-induced insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Mechanism of TGFbeta receptor inhibition by FKBP12

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

The dawn of developmental signaling in the metazoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Latent TGF-β structure and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Genetic analysis of the mammalian transforming growth factor-beta superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Metastasis: from dissemination to organ-specific colonization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Ryanodine receptors: structure, expression, molecular details, and function in calcium release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

A rapamycin-selective 25-kDa immunophilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Mammalian FKBP-25 and its associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Proteomic characterization of the human centrosome by protein correlation profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Characterization of an RNA granule from developing brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Multiple myeloma oncogene 1 (MUM1)/interferon regulatory factor 4 (IRF4) upregulates monokine induced by interferon-gamma (MIG) gene expression in B-cell malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

The Caenorhabditis elegans parvulin gene subfamily and their expression under cold or heat stress along with the fkb subfamily.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Mutations in FKBP14 cause a variant of Ehlers-Danlos syndrome with progressive kyphoscoliosis, myopathy, and hearing loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

The rough endoplasmic reticulum-resident FK506-binding protein FKBP65 is a molecular chaperone that interacts with collagens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Developmental regulation and coordinate reexpression of FKBP65 with extracellular matrix proteins after lung injury suggest a specialized function for this endoplasmic reticulum immunophilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Crystal structure of the three FK506 binding protein domains of wheat FKBP73: evidence for a unique wFK73_2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Mutations in FKBP10 cause both Bruck syndrome and isolated osteogenesis imperfecta in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Mutations in FKBP10 cause recessive osteogenesis imperfecta and Bruck syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

PPIB mutations cause severe osteogenesis imperfecta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

A novel human gene FKBP6 is deleted in Williams syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Affected homologous chromosome pairing and phosphorylation of testis specific histone, H2AX, in male meiosis under FKBP6 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

FKBP38-Bcl-2 interaction: a novel link to chemoresistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Structure-function analysis of squirrel monkey FK506-binding protein 51, a potent inhibitor of glucocorticoid receptor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

FKBP51 and FKBP52 in signaling and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

The ability of the immunophilin FKBP59-HBI to interact with the 90-kDa heat shock protein is encoded by its tetratricopeptide repeat domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Glucocorticoid receptor physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Deficiency of immunophilin FKBP52 promotes endometriosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

The immunophilin FKBP52 specifically binds to tubulin and prevents microtubule formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Galectin-1 markedly reduces the incidence of resorptions in mice missing immunophilin FKBP52

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Neuropsin cleaves EphB2 in the amygdala to control anxiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

A role for FKBP52 in Tau protein function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Uterine FK506-binding protein 52 (FKBP52)-peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Fkbp52 regulates androgen receptor transactivation activity and male urethra morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

FKBP52 deficiency-conferred uterine progesterone resistance is genetic background and pregnancy stage specific

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Targeted ablation reveals a novel role of FKBP52 in gene-specific regulation of glucocorticoid receptor transcriptional activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Characterization of the Ah receptor-associated protein, ARA9

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Growth factors, matrices, and forces combine and control stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Telomeres and cancer: from crisis to stability to crisis to stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Exploiting the cancer genome: strategies for the discovery and clinical development of targeted molecular therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Mutations in a new photoreceptor-pineal gene on 17p cause Leber congenital amaurosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

The emerging role of FK506-binding proteins as cancer biomarkers: a focus on FKBPL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

A novel FK506-like binding protein interacts with the glucocorticoid receptor and regulates steroid receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

The ulcerative colitis marker protein WAFL interacts with accessory proteins in endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

The worldwide Protein Data Bank (wwPDB): ensuring a single, uniform archive of PDB data

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

T cell responses in calcineurin A alpha-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Calcineurin-immunosuppressor complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Regulatory mechanisms of calcineurin phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Comparative analysis of calcineurin inhibition by complexes of immunosuppressive drugs with human FK506 binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

A second calcineurin binding site on the NFAT regulatory domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Structure of the Calcineurin-NFAT Complex: Defining a T Cell Activation Switch Using Solution NMR and Crystal Coordinates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Discovery of small-molecule inhibitors of the NFAT--calcineurin interaction by competitive high-throughput fluorescence polarization screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Balanced interactions of calcineurin with AKAP79 regulate Ca2+–calcineurin–NFAT signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

NFAT Binding and Regulation of T Cell Activation by the Cytoplasmic Scaffolding Homer Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Tor signalling in bugs, brain and brawn

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Chemical modification of rapamycin: the discovery of SDZ RAD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Recent advances in the chemistry, biosynthesis and pharmacology of rapamycin analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

North Central Cancer Treatment Group Phase I trial N057K of everolimus (RAD001) and temozolomide in combination with radiation therapy in patients with newly diagnosed glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Bench to bedside: the development of rapamycin and its application to stent restenosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Development of ATP-competitive mTOR inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Zotarolimus, a novel sirolimus analogue with potent anti-proliferative activity on coronary smooth muscle cells and reduced potential for systemic immunosuppression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Factors underlying sensitivity of cancers to small-molecule kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Lessons from natural molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Neuroimmunophilins: a novel drug therapy for the reversal of neurodegenerative disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

A crevice adjoining the ribosome tunnel: hints for cotranslational folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Topical tacrolimus and pimecrolimus in the treatment of cutaneous lupus erythematosus: an evidence-based evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Binding of pimecrolimus and tacrolimus to skin and plasma proteins: implications for systemic exposure after topical application

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Topical calcineurin inhibitors in cutaneous lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

What's new in atopic eczema?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Efficacy of sirolimus in treating tuberous sclerosis and lymphangioleiomyomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Molecular activity of sirolimus and its possible application in tuberous sclerosis treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Neointimal expression of rapamycin receptor FK506-binding protein FKBP12: postinjury animal and human in-stent restenosis tissue characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Multicenter phase 2 trial of sirolimus for tuberous sclerosis: kidney angiomyolipomas and other tumors regress and VEGF- D levels decrease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Everolimus for the treatment of advanced renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

A randomized controlled trial in second-generation zotarolimus-eluting Resolute stents versus everolimus-eluting Xience V stents in real-world patients: the TWENTE trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Multimodal biomarker investigation on efficacy and mechanism of action for the mammalian target of rapamycin inhibitor, temsirolimus, in a preclinical mammary carcinoma OncoMouse model: a translational medicine study in support for early clinical de

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Targeted therapies for renal cell carcinoma: review of adverse event management strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

New immunosuppressive drugs in heart transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Nuclear magnetic resonance fragment-based identification of novel FKBP12 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

FK1706, a novel non-immunosuppressive immunophilin ligand, modifies the course of painful diabetic neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Everolimus and sirolimus antagonize tacrolimus based calcineurin inhibition via competition for FK-binding protein 12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Targeting mTOR globally in cancer: thinking beyond rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Design and Structure-Based Study of New Potential FKBP12 Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Nocardiopsins: new FKBP12-binding macrolide polyketides from an Australian marine-derived actinomycete, Nocardiopsis sp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

The novel calcineurin inhibitor CN585 has potent immunosuppressive properties in stimulated human T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Evaluation of synthetic FK506 analogues as ligands for the FK506-binding proteins 51 and 52

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Exploration of pipecolate sulfonamides as binders of the FK506-binding proteins 51 and 52

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Targeting PI3 kinase/AKT/mTOR signaling in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

The mTOR signalling pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Novel therapies for metastatic renal cell carcinoma: efforts to expand beyond the VEGF/mTOR signaling paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

InTERTesting association between telomerase, mTOR and phytochemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Direct inhibition of calcineurin by caffeoyl phenylethanoid glycosides from Teucrium chamaedrys and Nepeta cataria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Calcineurin inhibitors and immunosuppression - a tale of two isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Extending healthy life span--from yeast to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Progeria, rapamycin and normal aging: recent breakthrough

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Sirolimus accelerates senescence of endothelial progenitor cells through telomerase inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Fat tissue, aging, and cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Genomics of human longevity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Telomeres, aging, and plants: from weeds to Methuselah - a mini-review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Aging and TOR: interwoven in the fabric of life

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Key factors in mTOR regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

[11C]GSK2126458 and [18F]GSK2126458, the first radiosynthesis of new potential PET agents for imaging of PI3K and mTOR in cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Acute sirolimus pulmonary toxicity in an infant heart transplant recipient: case report and literature review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Pharmacodynamic monitoring of calcineurin phosphatase activity in transplant patients treated with calcineurin inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Pharmacodynamic disparities in tacrolimus-treated patients developing cytomegalus virus viremia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Generation of Epstein-Barr virus-specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

An emerging role for TOR signaling in mammalian tissue and stem cell physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

TGF-beta: a master of all T cell trades

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

A Poised Chromatin Platform for TGF-β Access to Master Regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Immunosuppressor FK506 increases endoglin and activin receptor-like kinase 1 expression and modulates transforming growth factor-β1 signaling in endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Screening of immunophilin ligands by quantitative analysis of neurofilament expression and neurite outgrowth in cultured neurons and cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Chapter 18: Enhancement of nerve regeneration and recovery by immunosuppressive agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

The role of immunophilin ligands in nerve regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1206-Z

Calcineurin inhibitor nephrotoxicity

21 January 2018

1 reference

12 December 2020

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

1 reference

12 December 2020

On the localization of FKBP25 in T-lymphocytes

1 reference

12 December 2020

The human FK506-binding proteins: characterization of human FKBP19

1 reference

12 December 2020

Rapamycin induces the TGFbeta1/Smad signaling cascade in renal mesangial cells upstream of mTOR.

1 reference

12 December 2020

Loss of secretory pathway FK506-binding proteins results in cold-sensitive lethality and associate extracellular matrix defects in the nematode Caenorhabditis elegans

1 reference

12 December 2020

Identification and genetic mapping of the mouse Fkbp9 gene encoding a new member of FK506-binding protein family.

1 reference

12 December 2020

FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics

1 reference

12 December 2020

FKBP12-FK506 complex inhibits phosphatase activity of two mammalian isoforms of calcineurin irrespective of their substrates or activation mechanisms

1 reference

12 December 2020

Structural comparison of oxidized and reduced FKBP13 from Arabidopsis thaliana

1 reference

12 December 2020

15N NMR relaxation studies of the FK506 binding protein: dynamic effects of ligand binding and implications for calcineurin recognition

1 reference

12 December 2020

Calcineurin: form and function

1 reference

12 December 2020

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization

1 reference

12 December 2020

Sirolimus in solid organ transplantation: current therapies and new frontiers

1 reference

12 December 2020

The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein

1 reference

12 December 2020

Anchoring of the 26S proteasome to the organellar membrane by FKBP38.

1 reference

12 December 2020

Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands

1 reference

12 December 2020

The landscape of cancer genes and mutational processes in breast cancer

1 reference

12 December 2020

FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. I. Taxonomy of the producing strain

1 reference

12 December 2020

The binding of FKBP23 to BiP modulates BiP's ATPase activity with its PPIase activity

1 reference

12 December 2020

The TGF beta receptor activation process: an inhibitor- to substrate-binding switch

1 reference

12 December 2020

Crystal structure of a multi-domain immunophilin from Arabidopsis thaliana: a paradigm for regulation of plant ABC transporters

1 reference

12 December 2020

Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506.

1 reference

12 December 2020

Activity of rapamycin (AY-22,989) against transplanted tumors

1 reference

12 December 2020

Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.

1 reference

12 December 2020

Therapeutic implications of targeting the PI3Kinase/AKT/mTOR signaling module in melanoma therapy

1 reference

12 December 2020

The Fission Yeast TOR Proteins and the Rapamycin Response: An Unexpected Tale

1 reference

12 December 2020

Altered excitation-contraction coupling with skeletal muscle specific FKBP12 deficiency

1 reference

12 December 2020

Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506

1 reference

12 December 2020

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.

1 reference

12 December 2020

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.28.727

Identifiers

DOI

10.1007/S00018-012-1206-Z

1 reference

28 August 2017

1 reference