(Q38068039)

28 August 2017

1 reference

title

Genetic instability: tipping the balance (English)

1 reference

28 August 2017

2

1 reference

28 August 2017

A Janssen

1

0 references

language of work or name

English

0 references

publication date

17 December 2012

1 reference

28 August 2017

1 reference

28 August 2017

32

1 reference

28 August 2017

4459-4470

1 reference

28 August 2017

38

1 reference

https://scigraph.springernature.com/pub.10.1038/onc.2012.576

28 August 2017

0 references

cites work

Clinical significance of cytogenetic findings in solid tumors

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

The impact of translocations and gene fusions on cancer causation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Oncogenic transcription factors in the human acute leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

The landscape of somatic copy-number alteration across human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Molecular cytogenetic analysis of breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Genetic alterations in lobular breast cancer by comparative genomic hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Genetic alterations in primary breast cancers and their metastases: direct comparison using modified comparative genomic hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

DNA repair and chromosomal alterations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

DNA double strand breaks and chromosomal aberrations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Chromosomal aberrations: formation, identification and distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Chromosome breakage syndromes and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Mechanisms of chromosomal aberration production. 3. Chemicals and ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Human telomeres: fusion and interstitial sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Abnormal nuclear shape in solid tumors reflects mitotic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Genomic imbalances in 5918 malignant epithelial tumors: an explorative meta-analysis of chromosomal CGH data

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Constitutional aneuploidy in the normal human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

The ploidy conveyor of mature hepatocytes as a source of genetic variation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Genetic instability in colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Genetic instabilities in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Chromosomal instability is a risk factor for poor prognosis of adenocarcinoma of the lung: Fluorescence in situ hybridization analysis of paraffin-embedded tissue from Korean patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Chromosomal instability substantiates poor prognosis in patients with diffuse large B-cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Chromosome instability, chromosome transcriptome, and clonal evolution of tumor cell populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Chromosomal instability: a composite phenotype that influences sensitivity to chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Chromosomal instability confers intrinsic multidrug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Chromosomal instability determines taxane response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Cancer. Aneuploidy drives a mutator phenotype in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Does aneuploidy cause cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Cancer drug resistance: the central role of the karyotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Chromosomal instability and aneuploidy in cancer: from yeast to man

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

The role of chromosomal instability in tumor initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

The significance of unstable chromosomes in colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

The spindle-assembly checkpoint in space and time

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

On the road to cancer: aneuploidy and the mitotic checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Mutations of mitotic checkpoint genes in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Aneuploid colon cancer cells have a robust spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Correlation of defective mitotic checkpoint with aberrantly reduced expression of MAD2 protein in nasopharyngeal carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Identification of a human mitotic checkpoint gene: hsMAD2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Spindle assembly checkpoint defects and chromosomal instability in head and neck squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Frequent impairment of the spindle assembly checkpoint in hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Association of MAD2 expression with mitotic checkpoint competence in hepatoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Differential spindle assembly checkpoint response in human lung adenocarcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

A double missense variation of the BUB1 gene and a defective mitotic spindle checkpoint in the pancreatic cancer cell line Hs766T.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Mechanisms of aneuploidy in thyroid cancer cell lines and tissues: evidence for mitotic checkpoint dysfunction without mutations in BUB1 and BUBR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Chromosomal instability syndrome of total premature chromatid separation with mosaic variegated aneuploidy is defective in mitotic-spindle checkpoint.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

BUBR1 deficiency results in abnormal megakaryopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Characterization of MAD2B and other mitotic spindle checkpoint genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Mutation and expression analysis of human BUB1 and BUB1B in aneuploid breast cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Molecular analysis of the mitotic checkpoint genes BUB1, BUBR1 and BUB3 in human lung cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Increased expression of mitotic checkpoint genes in breast cancer cells with chromosomal instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Overexpression of the mitotic checkpoint genes BUB1, BUBR1, and BUB3 in gastric cancer--association with tumour cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Mitotic checkpoint protein hsMAD2 as a marker predicting liver metastasis of human gastric cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Diversity of gene expression in adenocarcinoma of the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

pRB, a tumor suppressor with a stabilizing presence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Loss of pRB causes centromere dysfunction and chromosomal instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Human Sgo1 downregulation leads to chromosomal instability in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Securin is required for chromosomal stability in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Three classes of genes mutated in colorectal cancers with chromosomal instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Mutational inactivation of STAG2 causes aneuploidy in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Overexpression of Separase induces aneuploidy and mammary tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Cohesin: its roles and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Examining the link between chromosomal instability and aneuploidy in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error correction is achieved by two different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Cell division control by the Chromosomal Passenger Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Centrosome amplification drives chromosomal instability in breast tumor development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Centrosome aberrations: cause or consequence of cancer progression?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

A mechanism linking extra centrosomes to chromosomal instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

The cell biology of cell-in-cell structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Entosis: aneuploidy by invasion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Chk1 and Chk2 kinases in checkpoint control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Deviant kinetochore microtubule dynamics underlie chromosomal instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Genome stability is ensured by temporal control of kinetochore-microtubule dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Checkpoint-independent stabilization of kinetochore-microtubule attachments by Mad2 in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Feedback control in sensing chromosome biorientation by the Aurora B kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Identification of FAP locus genes from chromosome 5q21

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Wnt/beta-catenin signaling in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Original CIN: reviewing roles for APC in chromosome instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

BubR1 and APC/EB1 cooperate to maintain metaphase chromosome alignment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Mislocalization of the Drosophila centromere-specific histone CID promotes formation of functional ectopic kinetochores

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Heterochromatin boundaries are hotspots for de novo kinetochore formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Defective chromosome segregation and telomere dysfunction in aggressive Wilms' tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Epigenetic regulation of centromeric chromatin: old dogs, new tricks?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

The expression level of HJURP has an independent prognostic impact and predicts the sensitivity to radiotherapy in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

DNA breaks and chromosome pulverization from errors in mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Aneuploidy drives genomic instability in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Instability of chromosome structure in cancer cells increases exponentially with degrees of aneuploidy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Genetic instability of cancer cells is proportional to their degree of aneuploidy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Generating chromosome instability through the simultaneous deletion of Mad2 and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Effects of aneuploidy on cellular physiology and cell division in haploid yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Replication stress induces 53BP1-containing OPT domains in G1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Whole chromosome instability and cancer: a complex relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

21 January 2018

Aneuploidy and cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Isolation and characterization of a pituitary tumor-transforming gene (PTTG)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Aneuploidy acts both oncogenically and as a tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis motor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Cancer chromosomal instability: therapeutic and diagnostic challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Losing balance: the origin and impact of aneuploidy in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Identification of aneuploidy-tolerating mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Aneuploidy, the primary cause of the multilateral genomic instability of neoplastic and preneoplastic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Paradoxical relationship between chromosomal instability and survival outcome in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Mitosis as an anti-cancer target

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Genomic stability and tumour suppression by the APC/C cofactor Cdh1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Pituitary hypoplasia in Pttg-/- mice is protective for Rb+/- pituitary tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

The minute chromosome (Phl) in chronic granulocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Chromosome aberrations in solid tumors have a stochastic nature

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Numerical chromosome aberrations in human neoplasia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Anaphase Spindle Mechanics Prevent Mis-Segregation of Merotelically Oriented Chromosomes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Kinetochores and microtubules in multipolar mitosis and chromosome orientation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Correlation between centrosome abnormalities and chromosomal instability in human pancreatic cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Mutations in the APC tumour suppressor gene cause chromosomal instability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.576

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.576

1 reference

PubMed ID

23246960

Dimensions Publication ID

28 August 2017

0 references

1 reference

PubMed ID

23246960