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English
Ubiquitinations in the notch signaling pathway.
scientific article published on 19 March 2013
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Europe PubMed Central
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3634445
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26 February 2020
title
Ubiquitinations in the notch signaling pathway
(English)
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Europe PubMed Central
PMC publication ID
3634445
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23519106%20AND%20SRC:MED&resulttype=core&format=json
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26 February 2020
main subject
protein ubiquitination
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Julien Moretti
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1
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Europe PubMed Central
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3634445
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26 February 2020
Christel Brou
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2
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Europe PubMed Central
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3634445
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26 February 2020
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Christel Brou
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28 August 2017
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English
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19 March 2013
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26 February 2020
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International Journal of Molecular Sciences
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26 February 2020
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14
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26 February 2020
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3
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26 February 2020
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6359-6381
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26 February 2020
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19 March 2013
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Intracellular trafficking of Notch receptors and ligands
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AIP4/Itch regulates Notch receptor degradation in the absence of ligand
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Endosomal entry regulates Notch receptor activation in Drosophila melanogaster
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Neuralized-like 1 (Neurl1) targeted to the plasma membrane by N-myristoylation regulates the Notch ligand Jagged1.
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6 September 2017
DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur
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6 September 2017
Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1
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6 September 2017
T cells develop normally in the absence of both Deltex1 and Deltex2
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6 September 2017
Notch signalling: a simple pathway becomes complex
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6 September 2017
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6 September 2017
The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands
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6 September 2017
Mind bomb 1 is essential for generating functional Notch ligands to activate Notch
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6 September 2017
The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta
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6 September 2017
Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila
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6 September 2017
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6 September 2017
Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover
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6 September 2017
Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.
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6 September 2017
Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain
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6 September 2017
The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity
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6 September 2017
Notch1 functions as a tumor suppressor in mouse skin
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Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase
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6 September 2017
Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta
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6 September 2017
The role of notch in promoting glial and neural stem cell fates
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6 September 2017
Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
6 September 2017
Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
6 September 2017
SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
6 September 2017
Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
6 September 2017
The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
6 September 2017
Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
6 September 2017
Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
6 September 2017
The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
6 September 2017
A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
6 September 2017
Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
6 September 2017
Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
6 September 2017
The Notch1 receptor is cleaved constitutively by a furin-like convertase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
6 September 2017
Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
6 September 2017
The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
6 September 2017
sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
6 September 2017
Expression of members of the novel membrane linked metalloproteinase family ADAM in cells derived from a range of haematological malignancies.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
6 September 2017
Maintenance of somite borders in mice requires the Delta homologue DII1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
6 September 2017
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
6 September 2017
Molecular cloning of Notch, a locus affecting neurogenesis in Drosophila melanogaster
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
6 September 2017
MDM2 protein-mediated ubiquitination of numb protein: identification of a second physiological substrate of MDM2 that employs a dual-site docking mechanism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
6 September 2017
Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
14 September 2017
Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
14 September 2017
c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane-associated Notch1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
28 September 2017
Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
28 September 2017
Cargo ubiquitination is essential for multivesicular body intralumenal vesicle formation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
23 June 2018
Mapping the Deltex-binding surface on the notch ankyrin domain using analytical ultracentrifugation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
23 June 2018
Numb regulates Notch1, but not Notch3, during myogenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
23 June 2018
The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
23 June 2018
Delta-like 4 is indispensable in thymic environment specific for T cell development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
23 June 2018
Requirement for dynamin during Notch signaling in Drosophila neurogenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
23 June 2018
An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
23 June 2018
Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase MDM2 activates the Notch signalling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
31 August 2018
Genetic identification of intracellular trafficking regulators involved in Notch-dependent binary cell fate acquisition following asymmetric cell division.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
31 August 2018
USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
31 August 2018
Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of notch in the endosomal trafficking pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
31 August 2018
The Drosophila Notch inhibitor and tumor suppressor gene lethal (2) giant discs encodes a conserved regulator of endosomal trafficking
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
31 August 2018
Regulation of Notch signalling by non-visual beta-arrestin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
31 August 2018
Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
31 August 2018
Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
31 August 2018
The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
31 August 2018
Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
31 August 2018
Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
31 August 2018
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
31 August 2018
Drosophila deltex mediates suppressor of Hairless-independent and late-endosomal activation of Notch signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
31 August 2018
Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
31 August 2018
Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
31 August 2018
neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
31 August 2018
Notch signalling acts in postmitotic avian myogenic cells to control MyoD activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
31 August 2018
The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
31 August 2018
Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
31 August 2018
The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634445
retrieved
31 August 2018
Itch genetically interacts with Notch1 in a mouse autoimmune disease model
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23519106
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Notch Activation by the Metalloproteinase ADAM17 Regulates Myeloproliferation and Atopic Barrier Immunity by Suppressing Epithelial Cytokine Synthesis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23519106
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.3390/IJMS14036359
1 reference
stated in
Europe PubMed Central
PMC publication ID
3634445
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23519106%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 February 2020
PMC publication ID
3634445
1 reference
stated in
Europe PubMed Central
PMC publication ID
3634445
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23519106%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 February 2020
PubMed publication ID
23519106
1 reference
stated in
Europe PubMed Central
PMC publication ID
3634445
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23519106%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 February 2020
ResearchGate publication ID
236071052
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