(Q38102608)

28 August 2017

title

LXR agonists: new potential therapeutic drug for neurodegenerative diseases (English)

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28 August 2017

1 reference

Pei Xu

1

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28 August 2017

Dabing Li

2

1 reference

28 August 2017

Xiaotong Tang

3

1 reference

28 August 2017

Xiaohang Bao

4

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28 August 2017

Jing Huang

5

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28 August 2017

Yongping Tang

6

1 reference

28 August 2017

Yang Yang

7

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28 August 2017

Haiwei Xu

8

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28 August 2017

Xiaotang Fan

9

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28 August 2017

publication date

27 April 2013

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28 August 2017

published in

Molecular Neurobiology

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28 August 2017

volume

48

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28 August 2017

issue

3

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28 August 2017

page(s)

715-728

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Brain cholesterol: long secret life behind a barrier.

28 August 2017

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Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines

21 January 2018

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21 January 2018

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ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice

21 January 2018

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Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice

21 January 2018

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T0901317 is a dual LXR/FXR agonist

21 January 2018

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CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor

21 January 2018

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Role of LXRs in control of lipogenesis

21 January 2018

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Targeting liver X receptors in human health: deadlock or promising trail?

21 January 2018

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Genome-wide expression profiling; a panel of mouse tissues discloses novel biological functions of liver X receptors in adrenals.

21 January 2018

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21 January 2018

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Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration

21 January 2018

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Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice

21 January 2018

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Neuropathologic and biochemical changes during disease progression in liver X receptor beta-/- mice, a model of adult neuron disease.

21 January 2018

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Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia

21 January 2018

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Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells

21 January 2018

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Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

21 January 2018

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Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation

21 January 2018

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Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors

21 January 2018

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21 January 2018

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A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

The effect of T0901317 on ATP-binding cassette transporter A1 and Niemann-Pick type C1 in apoE-/- mice

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Proton pump inhibitor lansoprazole is a nuclear liver X receptor agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Liver X receptors regulate cholesterol homeostasis in oligodendrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Regulation of macrophage functions by PPAR-alpha, PPAR-gamma, and LXRs in mice and men.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Liver X receptor agonist GW3965 dose-dependently regulates lps-mediated liver injury and modulates posttranscriptional TNF-alpha production and p38 mitogen-activated protein kinase activation in liver macrophages

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Liver X receptors bridge hepatic lipid metabolism and inflammation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Liver X receptor activation decreases the severity of experimental autoimmune encephalomyelitis.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

The many faces of PPARgamma: anti-inflammatory by any means?

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Liver X receptor agonist treatment regulates inflammatory response after spinal cord trauma

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Activation of liver X receptors promotes neuroprotection and reduces brain inflammation in experimental stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Immune function of astrocytes

21 January 2018

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Microglia as neuroprotective, immunocompetent cells of the CNS.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Liver X receptor and retinoid X receptor agonists inhibit inflammatory responses of microglia and astrocytes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Radial glia cells in the developing human brain

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Developmental transition in plasticity properties of differentiating astrocytes: age-related biochemical profile of plasminogen activators in astroglial cultures.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Expression of liver X receptor beta is essential for formation of superficial cortical layers and migration of later-born neurons

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Double-stranded RNA-activated protein kinase is required for the LPS-induced activation of STAT1 inflammatory signaling in rat brain glial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Differential SUMOylation of LXRalpha and LXRbeta mediates transrepression of STAT1 inflammatory signaling in IFN-gamma-stimulated brain astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease

21 January 2018

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Women, myocardial infarction, and dementia in the very old.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Cardiovascular disease and distribution of cognitive function in elderly people: the Rotterdam Study

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Risk factors for Alzheimer's disease and dementia: a case-control study based on the MRC elderly hypertension trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Apolipoprotein E alleles, dyslipidemia, and coronary heart disease. The Framingham Offspring Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Risk factors for cerebrovascular disease as correlates of cognitive function in a stroke-free cohort.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Coronary artery disease, hypertension, ApoE, and cholesterol: a link to Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Apolipoprotein E-4 gene dose in clinically diagnosed Alzheimer's disease: prevalence, plasma cholesterol levels and cerebrovascular change.

21 January 2018

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Cortical senile plaques in coronary artery disease, aging and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Cholesterol and cognition: rationale for the AD cholesterol-lowering treatment trial and sex-related Differences in beta-amyloid accumulation in the brains of spontaneously hypercholesterolemic Watanabe rabbits

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

APOE is a major susceptibility gene for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Abnormal in vivo metabolism of apolipoprotein E4 in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Cyp46 polymorphisms in Alzheimer's disease: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Lipid metabolism and neuroinflammation in Alzheimer's disease: a role for liver X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide Secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Impact of 27-hydroxycholesterol on amyloid-beta peptide production and ATP-binding cassette transporter expression in primary human neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Liver X receptor activation restores memory in aged AD mice without reducing amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Inflammation and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Expression profiling in APP23 mouse brain: inhibition of Abeta amyloidosis and inflammation in response to LXR agonist treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Liver X receptor activation attenuates inflammatory response and protects cholinergic neurons in APP/PS1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Liver-X-receptor activator prevents homocysteine-induced production of IgG antibodies from murine B lymphocytes via the ROS-NF-kappaB pathway

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Soybean isoflavone alleviates β-amyloid 1-42 induced inflammatory response to improve learning and memory ability by down regulation of Toll-like receptor 4 expression and nuclear factor-κB activity in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Critical Influences of the Cytokine Orchestration on the Outcome of Myelin Antigen‐Specific T‐Cell Autoimmunity in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

The pathology of multiple sclerosis: a historical perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Neuroscience. The dark side of glia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Decreased levels of the brain specific 24S-hydroxycholesterol and cholesterol precursors in serum of multiple sclerosis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Oxysterols as biomarkers in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Diagnostic use of cerebral and extracerebral oxysterols

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Interplay between LXR and Wnt/β-catenin signaling in the negative regulation of peripheral myelin genes by oxysterols.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Nuclear receptors take center stage in Th17 cell-mediated autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

The role of mitochondria in axonal degeneration and tissue repair in MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

The cellular pathology of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Total cholesterol and the risk of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Regulation of alpha-synuclein expression by liver X receptor ligands in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Isolation of various forms of sterol beta-D-glucoside from the seed of Cycas circinalis: neurotoxicity and implications for ALS-parkinsonism dementia complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Neurodegenerative disease. Guam's deadly stalker: on the loose worldwide?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Glia as a turning point in the therapeutic strategy of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Glia: initiators and progressors of pathology in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Role of glial cells in neurotoxin-induced animal models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Oxysterols drive dopaminergic neurogenesis from stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Liver X receptor β protects dopaminergic neurons in a mouse model of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Innate and adaptive immunity for the pathobiology of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Huntington disease models and human neuropathology: similarities and differences

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Cholesterol metabolism in Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Altered cholesterol and fatty acid metabolism in Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Transcriptional abnormalities in Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

The role of IκB kinase complex in the neurobiology of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Regulation of Cholesterol Homeostasis by the Liver X Receptors in the Central Nervous System

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Serum Cholesterol Levels and the Risk of Parkinson's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8461-3

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

21 January 2018

1 reference

12 December 2020

LXRs; oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis

1 reference

12 December 2020

Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology.

1 reference

12 December 2020

Expression of the receptor for complement C5a (CD88) is up-regulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system.

1 reference

12 December 2020

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.

1 reference

12 December 2020

ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

1 reference

12 December 2020

T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR

1 reference

12 December 2020

Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture

1 reference

12 December 2020

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10.1007/S12035-013-8461-3

Identifiers

DOI

1 reference

Dimensions Publication ID

28 August 2017

1049557561

0 references

1 reference