(Q38112644)

29 August 2017

title

Cbl-family proteins as regulators of cytoskeleton-dependent phenomena (English)

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29 August 2017

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Hojin Lee

1

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29 August 2017

Alexander Y Tsygankov

series ordinal

2

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29 August 2017

publication date

1 December 2013

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Journal of Cellular Physiology

29 August 2017

published in

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29 August 2017

volume

228

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29 August 2017

issue

12

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29 August 2017

page(s)

2285-2293

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The Loss of Cbl-Phosphatidylinositol 3-Kinase Interaction Perturbs RANKL-mediated Signaling, Inhibiting Bone Resorption and Promoting Osteoclast Survival

29 August 2017

cites work

1 reference

Structure of the leucine zipper

21 January 2018

1 reference

p85beta phosphoinositide 3-kinase regulates CD28 coreceptor function

21 January 2018

1 reference

SLI-1 Cbl inhibits the engulfment of apoptotic cells in C. elegans through a ligase-independent function

21 January 2018

1 reference

RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity

21 January 2018

1 reference

Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors

21 January 2018

1 reference

Leucine zipper-mediated homodimerization of the adaptor protein c-Cbl. A role in c-Cbl's tyrosine phosphorylation and its association with epidermal growth factor receptor

21 January 2018

1 reference

UBA domains of DNA damage-inducible proteins interact with ubiquitin

21 January 2018

1 reference

UBA domains mediate protein-protein interactions between two DNA damage-inducible proteins

21 January 2018

1 reference

Rac1 GTPase: a "Rac" of all trades.

21 January 2018

1 reference

Abrogation of Cbl-PI3K interaction increases bone formation and osteoblast proliferation

21 January 2018

1 reference

Rho and Rac take center stage

21 January 2018

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Dimers, leucine zippers and DNA-binding domains

21 January 2018

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The Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton

21 January 2018

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Big roles for small GTPases in the control of directed cell movement

21 January 2018

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Ubiquitin-associated (UBA) domains in Rad23 bind ubiquitin and promote inhibition of multi-ubiquitin chain assembly

21 January 2018

1 reference

Ablation of Cbl-b provides protection against transplanted and spontaneous tumors

21 January 2018

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Cbl-b regulates the CD28 dependence of T-cell activation.

21 January 2018

1 reference

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity

21 January 2018

1 reference

A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling

21 January 2018

1 reference

Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPases

21 January 2018

1 reference

Rapid ubiquitination of Syk following GPVI activation in platelets

21 January 2018

1 reference

Cbl-b is a novel physiologic regulator of glycoprotein VI-dependent platelet activation

21 January 2018

1 reference

Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b

21 January 2018

1 reference

The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion

21 January 2018

1 reference

MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells

21 January 2018

1 reference

Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl

21 January 2018

1 reference

Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGF receptor-mediated epithelial cell adherens junction dynamics and cell migration.

21 January 2018

1 reference

Vascular endothelial growth factor-dependent down-regulation of Flk-1/KDR involves Cbl-mediated ubiquitination. Consequences on nitric oxide production from endothelial cells

21 January 2018

1 reference

The genome of the social amoeba Dictyostelium discoideum

21 January 2018

1 reference

Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation

21 January 2018

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cbl-b inhibits epidermal growth factor receptor signaling

21 January 2018

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Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex

21 January 2018

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The small Rho GTPase Rif and actin cytoskeletal remodelling

21 January 2018

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Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.

21 January 2018

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Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

21 January 2018

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Potential disease targets for drugs that disrupt protein-- protein interactions of Grb2 and Crk family adaptors

21 January 2018

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SH3KBP1-binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex

21 January 2018

1 reference

Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells

21 January 2018

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Tyrosine phosphorylation of C-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of V-Abl-transformed NIH3T3 fibroblasts

21 January 2018

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Cbl-transforming variants trigger a cascade of molecular alterations that lead to epithelial mesenchymal conversion

21 January 2018

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Roles of Rho-family GTPases in cell polarisation and directional migration

21 January 2018

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Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration

21 January 2018

1 reference

Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl

21 January 2018

1 reference

Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

21 January 2018

1 reference

Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms

21 January 2018

1 reference

DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane

21 January 2018

1 reference

D-Cbl, the Drosophila homologue of the c-Cbl proto-oncogene, interacts with the Drosophila EGF receptor in vivo, despite lacking C-terminal adaptor binding sites.

21 January 2018

1 reference

Adoptive transfer of siRNA Cblb-silenced CD8+ T lymphocytes augments tumor vaccine efficacy in a B16 melanoma model

21 January 2018

1 reference

The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function

21 January 2018

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Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins

21 January 2018

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E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity

21 January 2018

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Roles of E3 ubiquitin ligases in cell adhesion and migration

21 January 2018

1 reference

Simulating EGFR-ERK signaling control by scaffold proteins KSR and MP1 reveals differential ligand-sensitivity co-regulated by Cbl-CIN85 and endophilin

21 January 2018

1 reference

Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase

21 January 2018

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Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration

21 January 2018

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Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.

21 January 2018

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The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

21 January 2018

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Cbl-mediated ubiquitination of alpha5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation

21 January 2018

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Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations

21 January 2018

1 reference

RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1

21 January 2018

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Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking

21 January 2018

1 reference

cbl-3: a new mammalian cbl family protein

21 January 2018

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Molecular cloning and characterization of a novel cbl-family gene, cbl-c

21 January 2018

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Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation

21 January 2018

1 reference

Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b

21 January 2018

1 reference

Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.

21 January 2018

1 reference

Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase

21 January 2018

1 reference

Differential Control of CD28-Regulated In Vivo Immunity by the E3 Ligase Cbl-b

21 January 2018

1 reference

Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening

21 January 2018

1 reference

RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion

21 January 2018

1 reference

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

21 January 2018

1 reference

A Dictyostelium homologue of the metazoan Cbl proteins regulates STAT signalling.

21 January 2018

1 reference

c-Cbl facilitates cytoskeletal effects in v-Abl transformed fibroblast through Rac1- and Rap1-mediated signaling

21 January 2018

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c-Cbl regulates glioma invasion through matrix metalloproteinase 2.

21 January 2018

1 reference

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

21 January 2018

1 reference

c-Cbl is a suppressor of the neu oncogene

21 January 2018

1 reference

RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis

21 January 2018

1 reference

APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes

21 January 2018

1 reference

The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport

21 January 2018

1 reference

The GTPase Rap1 regulates phorbol 12-myristate 13-acetate-stimulated but not ligand-induced beta 1 integrin-dependent leukocyte adhesion

21 January 2018

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Ras-dependent, Ca2+-stimulated activation of nuclear factor of activated T cells by a constitutively active Cbl mutant in T cells.

21 January 2018

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Cbl: complex formation and functional implications

21 January 2018

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Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells

21 January 2018

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The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.

21 January 2018

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C3G forms complexes with Bcr-Abl and p38α MAPK at the focal adhesions in chronic myeloid leukemia cells: implication in the regulation of leukemic cell adhesion.

21 January 2018

1 reference

A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration

21 January 2018

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Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

21 January 2018

1 reference

Role of Cbl in shear-activation of PI 3-kinase and JNK in endothelial cells

21 January 2018

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Lipid products of phosphoinositide 3-kinase interact with Rac1 GTPase and stimulate GDP dissociation

21 January 2018

1 reference

Cbl PYXXM motifs activate the P85 subunit of phosphatidylinositol 3-kinase, Crk, atypical protein kinase C, and glucose transport during thiazolidinedione action in 3T3/L1 and human adipocytes

21 January 2018

1 reference

Cbl-mediated ubiquitinylation and negative regulation of Vav.

21 January 2018

1 reference

Src kinase activity is essential for osteoclast function

21 January 2018

1 reference

Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases

21 January 2018

1 reference

FGF receptors ubiquitylation: dependence on tyrosine kinase activity and role in downregulation

21 January 2018

1 reference

A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion

21 January 2018

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Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

21 January 2018

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Roles of membrane type 1 matrix metalloproteinase and tissue inhibitor of metalloproteinases 2 in invasion and dissemination of human malignant glioma.

21 January 2018

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Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia

21 January 2018

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Altered thymic positive selection and intracellular signals in Cbl-deficient mice

21 January 2018

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Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates

21 January 2018

1 reference

Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking

21 January 2018

1 reference

Nerve growth factor signals through TrkA, phosphatidylinositol 3-kinase, and Rac1 to inactivate RhoA during the initiation of neuronal differentiation of PC12 cells

21 January 2018

1 reference

FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling

21 January 2018

1 reference

Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions

21 January 2018

1 reference

Rac and Rho GTPases in cancer cell motility control

21 January 2018

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c-Cbl is a critical modulator of the Ron tyrosine kinase receptor

21 January 2018

1 reference

Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein

21 January 2018

1 reference

A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation.

21 January 2018

1 reference

The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

21 January 2018

1 reference

Multifaceted role of Rho, Rac, Cdc42 and Ras in intercellular junctions, lessons from toxins

21 January 2018

1 reference

c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomes

21 January 2018

1 reference

Signalling to actin: role of C3G, a multitasking guanine-nucleotide-exchange factor

21 January 2018

1 reference

Cell migration: Rho GTPases lead the way

21 January 2018

1 reference

Molecular mechanisms of glioma invasiveness: the role of proteases

21 January 2018

1 reference

The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.

21 January 2018

1 reference

Negative regulation of Lck by Cbl ubiquitin ligase

21 January 2018

1 reference

c-Cbl deficiency leads to diminished lymphocyte development and functions in an age-dependent manner

21 January 2018

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The small GTPase, Rap1, mediates CD31-induced integrin adhesion

21 January 2018

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Ubiquitylation-dependent negative regulation of WASp is essential for actin cytoskeleton dynamics

21 January 2018

1 reference

CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes.

21 January 2018

1 reference

Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking

21 January 2018

1 reference

A Drosophila analogue of v-Cbl is a dominant-negative oncoprotein in vivo

21 January 2018

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Negative regulation of receptor tyrosine kinases: unexpected links to c-Cbl and receptor ubiquitylation

21 January 2018

1 reference

Regulating the regulator: negative regulation of Cbl ubiquitin ligases

21 January 2018

1 reference

The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme

21 January 2018

1 reference

Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry

21 January 2018

1 reference

Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms

21 January 2018

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Flt3-dependent transformation by inactivating c-Cbl mutations in AML

21 January 2018

1 reference

The multi-adaptor proto-oncoprotein Cbl is a key regulator of Rac and actin assembly

21 January 2018

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Rapid microtubule-dependent induction of neurite-like extensions in NIH 3T3 fibroblasts by inhibition of ROCK and Cbl

21 January 2018

1 reference

The Cbl interactome and its functions

21 January 2018

1 reference

CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies

21 January 2018

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Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

21 January 2018

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Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase.

21 January 2018

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Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligase.

21 January 2018

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Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling

21 January 2018

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Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors

21 January 2018

1 reference

Dynamics of the Rho-family small GTPases in actin regulation and motility

21 January 2018

1 reference

Requirements for pYXXM motifs in Cbl for binding to the p85 subunit of phosphatidylinositol 3-kinase and Crk, and activation of atypical protein kinase C and glucose transport during insulin action in 3T3/L1 adipocytes

21 January 2018

1 reference

Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway

21 January 2018

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Abrogating Cbl-b in effector CD8+ T cells improves the efficacy of adoptive therapy of leukemia in mice

21 January 2018

1 reference

Identification of another actin-related protein (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP.

21 January 2018

1 reference

Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1

21 January 2018

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Additional Serine/Threonine Phosphorylation Reduces Binding Affinity but Preserves Interface Topography of Substrate Proteins to the c-Cbl TKB Domain

21 January 2018

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The Cbl family proteins: ring leaders in regulation of cell signaling

21 January 2018

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c-Cbl-facilitated cytoskeletal effects in v-Abl-transformed fibroblasts are regulated by membrane association of c-Cbl

21 January 2018

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CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases

21 January 2018

1 reference

SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling

21 January 2018

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c-Cbl facilitates fibronectin matrix production by v-Abl-transformed NIH3T3 cells via activation of small GTPases

21 January 2018

1 reference

The multidomain protooncogenic protein c-Cbl binds to tubulin and stabilizes microtubules

21 January 2018

1 reference

c-Cbl regulates migration of v-Abl-transformed NIH 3T3 fibroblasts via Rac1.

21 January 2018

1 reference

RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation

21 January 2018

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A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase

21 January 2018

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Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.

21 January 2018

1 reference

Negative regulation of PTK signalling by Cbl proteins

21 January 2018

1 reference

c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses

21 January 2018

1 reference

The critical cytoplasmic regions of the alphaL/beta2 integrin in Rap1-induced adhesion and migration

21 January 2018

1 reference

Beyond the RING: CBL proteins as multivalent adapters

21 January 2018

1 reference

The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration

21 January 2018

1 reference

Involvement of the adapter protein CRKL in integrin-mediated adhesion

21 January 2018

1 reference

Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation

21 January 2018

1 reference

Podosome regulation by Rho GTPases in myeloid cells

21 January 2018

1 reference

Induction of membrane-type-1 matrix metalloproteinase by epidermal growth factor-mediated signaling in gliomas.

21 January 2018

1 reference

Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell development

21 January 2018

1 reference

EphrinA5 suppresses colon cancer development by negatively regulating epidermal growth factor receptor stability

21 January 2018

1 reference

Shear Stress Regulates the Flk-1/Cbl/PI3K/NF-κB Pathway Via Actin and Tyrosine Kinases

21 January 2018

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Regulators of Rho GTPases in neuronal development.

21 January 2018

1 reference

Proteins containing the UBA domain are able to bind to multi-ubiquitin chains

21 January 2018

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Focal adhesion regulation of cell behavior.

21 January 2018

1 reference

Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A.

21 January 2018

1 reference

Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7

21 January 2018

1 reference

21 January 2018

1 reference

Requirements of multiple domains of SLI-1, a Caenorhabditis elegans homologue of c-Cbl, and an inhibitory tyrosine in LET-23 in regulating vulval differentiation

21 January 2018

1 reference

ARAP1 association with CIN85 affects epidermal growth factor receptor endocytic trafficking

21 January 2018

1 reference

Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl).

21 January 2018

1 reference

Negative regulation of T cell antigen receptor-mediated Crk-L-C3G signaling and cell adhesion by Cbl-b.

21 January 2018

1 reference

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

21 January 2018

1 reference

Differential ubiquitin binding of the UBA domains from human c-Cbl and Cbl-b: NMR structural and biochemical insights

21 January 2018

1 reference

M-CSF Regulates the Cytoskeleton via Recruitment of a Multimeric Signaling Complex to c-Fms Tyr-559/697/721

21 January 2018

1 reference

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/JCP.24412

1 reference

29 August 2017

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