(Q38128592)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23941336%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

title

The evolution of our understanding of endo-xenobiotic crosstalk and cytochrome P450 regulation and the therapeutic implications (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23941336%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

language of work or name

English

0 references

publication date

13 August 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23941336%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Drug Metabolism & Toxicology

7 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23941336%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23941336%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23941336%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

page(s)

1541-1554

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23941336%20AND%20SRC:MED&resulttype=core&format=json

Variations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamily

7 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Approaches to deorphanization of human and microbial cytochrome P450 enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

The human intestinal cytochrome P450 "pie".

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Cross-talk between xenobiotic detoxication and other signalling pathways: clinical and toxicological consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Progress in tracing the evolutionary paths of cytochrome P450

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

The cytochrome P450 genesis locus: the origin and evolution of animal cytochrome P450s

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Cytochromes P450: a success story

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Cytochrome P450 and the individuality of species

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Evolution of cytochrome p450 genes from the viewpoint of genome informatics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Independent elaboration of steroid hormone signaling pathways in metazoans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Catalytic versus inhibitory promiscuity in cytochrome P450s: implications for evolution of new function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Rapid birth-death evolution specific to xenobiotic cytochrome P450 genes in vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Structure and chemistry of cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Bacterial cytochromes P-450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Mycobacterium tuberculosis cytochrome P450 enzymes: a cohort of novel TB drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

The preponderance of P450s in the Mycobacterium tuberculosis genome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Dissection of the heat-shock response in Mycobacterium tuberculosis using mutants and microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Expression and characterization of Mycobacterium tuberculosis CYP144: common themes and lessons learned in the M. tuberculosis P450 enzyme family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Involvement of cytochrome P450 in pentachlorophenol transformation in a white rot fungus Phanerochaete chrysosporium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Molecular and functional diversity of fungal cytochrome P450s

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Cytochrome P450 enzymes in the fungal kingdom

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Cytochrome P450 CYP94B3 mediates catabolism and inactivation of the plant hormone jasmonoyl-L-isoleucine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Recent studies on insect hormone metabolic pathways mediated by cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Insights into the function and evolution of P450s in plant steroid metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

A different function for a member of an ancient and highly conserved cytochrome P450 family: from essential sterols to plant defense.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Metabolic diversification--independent assembly of operon-like gene clusters in different plants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

A gene cluster for secondary metabolism in oat: implications for the evolution of metabolic diversity in plants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Impacts of diversification of cytochrome P450 on plant metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Arthropod CYPomes illustrate the tempo and mode in P450 evolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Diversity and substrate specificity in the structures of steroidogenic cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

21 January 2018

The Protein Data Bank

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

21 January 2018

What makes a P450 tick?

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Cytochrome P450/redox partner fusion enzymes: biotechnological and toxicological prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Cytochrome P450 compound I: capture, characterization, and C-H bond activation kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

New cytochrome P450 mechanisms: implications for understanding molecular basis for drug toxicity at the level of the cytochrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Motion and flexibility in human cytochrome p450 aromatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

P450 BM3: the very model of a modern flavocytochrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Organization of cytochrome P450 enzymes involved in sex steroid synthesis: PROTEIN-PROTEIN INTERACTIONS IN LIPID MEMBRANES.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Microsomal monooxygenase as a multienzyme system: the role of P450-P450 interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Cooperative properties of cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

A missense mutation in the human cytochrome b5 gene causes 46,XY disorder of sex development due to true isolated 17,20 lyase deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Homozygous mutation G539R in the gene for P450 oxidoreductase in a family previously diagnosed as having 17,20-lyase deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Catalytic turnover of pyrene by CYP3A4: evidence that cytochrome b5 directly induces positive cooperativity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Kinetic and spectroscopic probes of motions and catalysis in the cytochrome P450 reductase family of enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Gating mechanisms for biological electron transfer: integrating structure with biophysics reveals the nature of redox control in cytochrome P450 reductase and copper-dependent nitrite reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

CYP induction-mediated drug interactions: in vitro assessment and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Human cytochrome P450 4F3: structure, functions, and prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

CHIP and gp78-mediated ubiquitination of CYP3A4: Implications for the pharmacology of anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

CYP1B1 and hormone-induced cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Ethanol-mediated regulation of cytochrome P450 2A6 expression in monocytes: role of oxidative stress-mediated PKC/MEK/Nrf2 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinical

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Cytochrome P450 networks in chemical space

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Cytochrome P450 gene regulation and physiological functions mediated by the aryl hydrocarbon receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Timing is everything: consequences of transient and sustained AhR activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Analysis of human CYP1A1 and CYP1A2 genes and their shared bidirectional promoter in eight world populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

A common regulatory region functions bidirectionally in transcriptional activation of the human CYP1A1 and CYP1A2 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Molecular phylogenies and evolutionary behavior of AhR (aryl hydrocarbon receptor) pathway genes in aquatic animals: implications for the toxicology mechanism of some persistent organic pollutants (POPs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Cytochrome P450 (CYP) in fish

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Coordinate regulation of cytochrome P450 1a1 expression in mouse liver by the aryl hydrocarbon receptor and the beta-catenin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Cross-talk of dioxin and estrogen receptor signals through the ubiquitin system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Human CYP1B1 is regulated by estradiol via estrogen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Regulation of uterine AHR battery gene expression by 17β-Estradiol is predominantly mediated by estrogen receptor α.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Effects of triclocarban on the transcription of estrogen, androgen and aryl hydrocarbon receptor responsive genes in human breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Interplay of pregnane X receptor with other nuclear receptors on gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

MicroRNAs regulate CYP3A4 expression via direct and indirect targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

MicroRNA-27b contributes to lipopolysaccharide-mediated peroxisome proliferator-activated receptor gamma (PPARgamma) mRNA destabilization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Flavonoids activate pregnane x receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Cytochrome P450--redox partner fusion enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

The effect of oral lipids and circulating lipoproteins on the metabolism of drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Cytochromes P450 are essential players in the vitamin D signaling system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" Problem

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Origin and diversification of steroids: co-evolution of enzymes and nuclear receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

On the general mechanism of selective induction of cytochrome P450 enzymes by chemicals: some theoretical considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Aromatase, breast cancer and obesity: a complex interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Diminished carcinogen detoxification is a novel mechanism for hypoxia-inducible factor 1-mediated genetic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

MicroRNA regulates the expression of human cytochrome P450 1B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Tissue physiology and pathology of aromatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Activation of the aryl hydrocarbon receptor sensitises human keratinocytes for CD95L- and TRAIL-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Interplay between cholesterol and drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Cholesterol, an essential molecule: diverse roles involving cytochrome P450 enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

In vitro-to-in vivo predictions of drug-drug interactions involving multiple reversible inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

"Drugs on oxygen": an update and perspective on the role of cytochrome P450 testing in pharmacology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Human cytochrome P450 2E1 mutations that alter mitochondrial targeting efficiency and susceptibility to ethanol-induced toxicity in cellular models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Pharmacogenomics of the RNA world: structural RNA polymorphisms in drug therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Mechanisms of drug toxicity and relevance to pharmaceutical development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Bioluminescent assays for ADME evaluation: dialing in CYP selectivity with luminogenic substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Engineering cytochrome P450 biocatalysts for biotechnology, medicine and bioremediation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Drug-mediated toxicity: illuminating the 'bad' in the test tube by means of cellular assays?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Novel Aromatase Inhibitors by Structure-Guided Design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Inhibition of the phosphatidylinositol 3-kinase/Akt pathway improves response of long-term estrogen-deprived breast cancer xenografts to antiestrogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Human Cytochrome P450 1A1 Structure and Utility in Understanding Drug and Xenobiotic Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Selective blockade of androgenic steroid synthesis by novel lyase inhibitors as a therapeutic strategy for treating metastatic prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Anti-androgens and androgen-depleting therapies in prostate cancer: new agents for an established target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Activation of vascular endothelial growth factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic acid-induced endothelial cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

P450 in the angiogenesis affair: the unusual suspect

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Smooth muscle--specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Cytochrome P450-derived eicosanoids: the neglected pathway in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Drug cocktail optimization in chemotherapy of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Chemistry. Re-engineering nature's catalysts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Enantioselective alpha-hydroxylation of 2-arylacetic acid derivatives and buspirone catalyzed by engineered cytochrome P450 BM-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Cytochrome P450 biosensors-a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Engineering and application of P450 monooxygenases in pharmaceutical and metabolite synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450(BM3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Practical application of cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Vitamin D and human health: lessons from vitamin D receptor null mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Novel advances in cytochrome P450 research

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

A P450-centric view of plant evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

Aromatase, aromatase inhibitors, and breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.828692

10.1517/17425255.2013.828692

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23941336%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference