(Q38151521)

29 August 2017

title

Metabolic alteration in tumorigenesis (English)

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29 August 2017

Hui Yang

1

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29 August 2017

Yue Xiong

series ordinal

2

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29 August 2017

KunLiang Guan

series ordinal

3

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29 August 2017

publication date

10 October 2013

1 reference

Science in China. Series C: Life Sciences

29 August 2017

published in

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29 August 2017

volume

56

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29 August 2017

issue

12

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29 August 2017

page(s)

1067-1075

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On the Origin of Cancer Cells

29 August 2017

cites work

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21 January 2018

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Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

21 January 2018

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Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?

21 January 2018

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ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells.

21 January 2018

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SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma

21 January 2018

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Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma

21 January 2018

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Familial gastrointestinal stromal tumors and germ-line mutations.

21 January 2018

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Germline SDHB mutations and familial renal cell carcinoma.

21 January 2018

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21 January 2018

SDH mutations in cancer

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Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

21 January 2018

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Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

21 January 2018

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Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

21 January 2018

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Cerebral cavernomas in a family with multiple cutaneous and uterine leiomyomas associated with a new mutation in the fumarate hydratase gene.

21 January 2018

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Germline fumarate hydratase mutations in patients with ovarian mucinous cystadenoma

21 January 2018

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IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors

21 January 2018

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Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.

21 January 2018

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IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas

21 January 2018

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IDH1 and IDH2 mutations in gliomas

21 January 2018

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Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation.

21 January 2018

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IDH mutations in glioma and acute myeloid leukemia

21 January 2018

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Segregation of non-p.R132H mutations in IDH1 in distinct molecular subtypes of glioma

21 January 2018

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Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

21 January 2018

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Molecular alterations of the IDH1 gene in AML: a Children's Oncology Group and Southwest Oncology Group study

21 January 2018

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21 January 2018

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Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor

21 January 2018

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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

21 January 2018

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IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

21 January 2018

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Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2.

21 January 2018

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Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome

21 January 2018

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Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping

21 January 2018

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Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas

21 January 2018

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Identification of several novel non-p.R132 IDH1 variants in thyroid carcinomas

21 January 2018

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21 January 2018

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21 January 2018

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Isocitrate dehydrogenase mutations are rare in pheochromocytomas and paragangliomas.

21 January 2018

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21 January 2018

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

21 January 2018

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

21 January 2018

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Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production

21 January 2018

1 reference

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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

Detection of "oncometabolite" 2-hydroxyglutarate by magnetic resonance analysis as a biomarker of IDH1/2 mutations in glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

Inhibition of 2-oxoglutarate dependent oxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

Expanding chemical biology of 2-oxoglutarate oxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

Mechanism of the Prolyl Hydroxylase Reaction. 1. Role of Co-substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

SDH mutations establish a hypermethylator phenotype in paraganglioma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

IDH mutation impairs histone demethylation and results in a block to cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

Succinate Dehydrogenase B Gene Mutations Predict Survival in Patients with Malignant Pheochromocytomas or Paragangliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

Adult Leydig Cell Tumors of the Testis Caused by Germline Fumarate Hydratase Mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-013-4549-2

10.1007/S11427-013-4549-2

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

29 August 2017

1014048202

0 references

1 reference